FTO gene polymorphisms (rs9939609 and rs17817449) as predictors of Type 2 Diabetes Mellitus in obese Iraqi population

Gene ◽  
2017 ◽  
Vol 627 ◽  
pp. 79-84 ◽  
Author(s):  
Laith A. Younus ◽  
Abdul Hussein A. Algenabi ◽  
Mohammed S. Abdul-Zhara ◽  
Majid K. Hussein
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Gene Polymorphisms ◽  
Fto Gene

scholarly journals Association of Glutathione-S-Transferase (GSTM1 and GSTT1) and FTO Gene Polymorphisms with Type 2 Diabetes Mellitus Cases in Northern India

2014 ◽  
Vol 17 (1) ◽  
pp. 47-54 ◽  
Author(s):  
Raza S.T. ◽  
Abbas S. ◽  
Ahmad A. ◽  
Ahmed F. ◽  
Zaidi Z.H. ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Gene Polymorphism ◽  
Gene Polymorphisms ◽  
Predictive Marker ◽  
Glutathione S Transferase ◽  
Fto Gene ◽  
Number Of Patients

Abstract Type 2 diabetes mellitus (T2DM) is growing in an epidemic manner across the world and India has the world’s largest number of diabetic subjects. The present study was carried out to investigate the association of glutathione-S-transferase (GSTM1, GSTT1) and fat mass and obesity associated (FTO) gene polymorphisms with T2DM patients and controls, and its role in increasing the susceptibility to T2DM. A total of 198 subjects (101 T2DM patients and 97 controls) participated in this study. GSTM1, GSTT1 and FTO gene polymorphisms in the patients and controls were evaluated by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP). We observed significant association of GSTM1 positive (p = 0.046) and GSTM1 null (p = 0.046) genotypes with T2DM, while no significant association was found with the FTO gene polymorphism in our study. It seems that the GSTM1 gene polymorphism can be a predictive marker for early identification of a population at risk of T2DM. The potential role of GST and FTO gene polymorphisms as a marker of susceptibility to T2DM needs further studies in a larger number of patients.

Association between FTO gene polymorphisms and type 2 diabetes mellitus, serum levels of apelin and androgen hormones among Iranian obese women

Gene ◽  
2018 ◽  
Vol 641 ◽  
pp. 361-366 ◽  
Author(s):  
Farzaneh Ghafarian-Alipour ◽  
Shayan Ziaee ◽  
Mohamad Reza Ashoori ◽  
Mir Saeid Zakeri ◽  
Mohammad Ali Boroumand ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Gene Polymorphisms ◽  
Serum Levels ◽  
Obese Women ◽  
Fto Gene

Mitochondrial D-Loop gene polymorphisms in the patients with type 2 diabetes mellitus

2009 ◽  
Vol 31 (3) ◽  
pp. 265-272 ◽  
Author(s):  
Fang-Jian CHEN ◽  
Hong YU ◽  
Fan FAN ◽  
Jian-Xin LU
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Gene Polymorphisms ◽  
D Loop

scholarly journals PPARG and ADIPOQ gene polymorphisms increase type 2 diabetes mellitus risk in Asian Indian Sikhs: Pro12Ala still remains as the strongest predictor

Metabolism ◽  
2010 ◽  
Vol 59 (4) ◽  
pp. 492-501 ◽  
Author(s):  
Dharambir Kaur Sanghera ◽  
Fatma Yesim Demirci ◽  
Latonya Been ◽  
Lyda Ortega ◽  
Sarju Ralhan ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Asian Indian ◽  
Gene Polymorphisms ◽  
Adipoq Gene ◽  
Diabetes Mellitus Risk

scholarly journals GTP Cyclohydrolase I Gene Polymorphisms Are Associated with Endothelial Dysfunction and Oxidative Stress in Patients with Type 2 Diabetes Mellitus

PLoS ONE ◽  
2014 ◽  
Vol 9 (11) ◽  
pp. e108587 ◽  
Author(s):  
Pawel P. Wolkow ◽  
Wladyslaw Kosiniak-Kamysz ◽  
Grzegorz Osmenda ◽  
Grzegorz Wilk ◽  
Beata Bujak-Gizycka ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Endothelial Dysfunction ◽  
Gene Polymorphisms ◽  
Gtp Cyclohydrolase I ◽  
And Oxidative Stress ◽  
I Gene

scholarly journals Calpain-10 gene polymorphisms and risk of type 2 diabetes mellitus in Mexican mestizos

2015 ◽  
Vol 14 (1) ◽  
pp. 2205-2215 ◽  
Author(s):  
V.J. Picos-Cárdenas ◽  
E. Sáinz-González ◽  
A. Miliar-García ◽  
A. Romero-Zazueta ◽  
R. Quintero-Osuna ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Gene Polymorphisms ◽  
Calpain 10 ◽  
Mexican Mestizos
Sign in / Sign up

Export Citation Format

Share Document