Tu1049 DE NOVO POST ERCP FEVER AND DE NOVO POST ERCP BACTEREMIA IN PATIENTS WITH HISTORY OF BARIATRIC SURGERY-- INCIDENCE, RISK FACTORS AND OUTCOMES

Abstract Background and Aims Performing a mucosectomy with a hand-sewn ileal pouch-anal anastomosis [IPAA] for ulcerative colitis [UC] theoretically reduces the risk of carcinoma arising from the anal transitional zone [ATZ]. Although current guidelines suggest a stapled anastomosis due to the low incidence of cancer after pouch surgery in UC patients, only a few small series have addressed the oncological advantage of mucosectomy. Therefore, we aimed to investigate the incidence of ATZ/pouch cancer. Methods A total of 1970 UC patients who underwent surgery between April 1987 and December 2018 were included. We retrospectively analysed the incidences of primary ATZ cancer in the original operative specimen and de novo ATZ/pouch cancer after surgery. Possible risk factors for primary ATZ cancer and the pouch survival rate were assessed. Results Fourteen [6.4%] primary ATZ cancers developed in 220 UC-colorectal cancer [CRC] cases. Multiple (odds ratio [OR] = 8.79, 95% confidence interval [CI] 2.77–27.83, p < 0.01) and rectal [OR = 6.48, 95% CI 1.41–29.7, p = 0.01] cancers were identified as independent risk factors for primary ATZ cancer. Four of 1970 [0.2%] patients developed de novo ATZ/pouch cancer and dysplasia. The 10-year estimated cumulative pouch survival rate was not significantly different between stapled IPAA and hand-sewn IPAA cases [95.9% and 97.3%, p = 0.25]. Conclusion The risk of de novo ATZ/pouch cancer and dysplasia was rare. The decision to perform a hand-sewn or a stapled IAA should be made on a case-by-case basis. However, the relatively high incidence of primary ATZ cancer in UC patients with CRC suggests that mucosectomy should be recommended for this patient group.

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Salivary Gland Lithiasis Recurrence After Minimally‐Invasive Surgery: Incidence, Risk Factors and Prevention

The Laryngoscope ◽

10.1002/lary.28991 ◽

2020 ◽

Author(s):

Philippe Galli ◽

Antoine Ceva ◽

Jean‐Marc Foletti ◽

Nicolas Iline ◽

Roch Giorgi ◽

...

Keyword(s):

Risk Factors ◽

Salivary Gland ◽

Minimally Invasive Surgery ◽

Minimally Invasive ◽

Invasive Surgery ◽

Incidence Risk ◽

Surgery Incidence

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A single-institution survey of de novo secondary malignancies in patients occurring after orthotropic liver transplantation.

Journal of Clinical Oncology ◽

10.1200/jco.2012.30.4_suppl.297 ◽

2012 ◽

Vol 30 (4_suppl) ◽

pp. 297-297

Author(s):

Quentin Gillebert ◽

Mohamed Bouattour ◽

Francois Durand ◽

Claire Francoz ◽

Valerie Paradis ◽

...

Keyword(s):

Risk Factors ◽

Liver Transplantation ◽

De Novo ◽

Secondary Malignancy ◽

Prior History ◽

Lung Cancers ◽

History Of ◽

Independent Risk Factors ◽

De Novo Cancer ◽

Tumor Types

297 Background: We aim to evaluate in our institution the incidence of de novo malignancies following orthotopic liver transplantation (OLT) and their impact the prognosis of patients (pts). Methods: Pts treated with OLT from August 1991 To March 2009 were considered in this analysis. All pts data had been prospectively recorded in the database of French “Bio-medecine Agence”. Pts were considered for this analysis only if they survived at least 3-months after. Occurrence of de novo malignancies we analyzed and additional data (including immunosuppressive profile, type of cancer, potential independent risk factors of cancers, prognosis and the influence of immunosuppression protocols or risk factors on occurrence of cancers) were collected in patients who developed secondary cancers. Results: A total of 833 patients who underwent OLT were considered for this analysis. With a median follow-up of 7.9 years, 72 pts developed 92 de novo malignancies. The overall incidence of cancers in our population was 10.4% occurring with a median time of 6.1 years following OLT. Sixteen pts developed 2 different types of cancer and 2 pts had more than 3 tumor types. Before 12/1998, immunosuppression was primarily based on cyclosporine, steroids and/or azathiopirine, and since 01/1999 was switched to tacrolimus. Incidence of cancers regarding these two periods is summarized in the table. Before 1998, only 3 pts (17.6%) with secondary cancer had prior history of alcoholism and/or smoking compared to 27 pts (50%) after 1999. Thirty one deaths were observed and the median overall survival (OS) after the time of diagnosis of secondary malignancy was 5.62 years. Conclusions: The risk of de novo cancer after OLT is similar to reported series. History of smoking and alcohol use, increase the incidence of de novo malignancies especially head and neck and lung cancers however, immunosuppression type may not interfere with this risk. [Table: see text]

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