Role of Toll-Like Receptor–Driven Innate Immunity in Thoracic Organ Transplantation

2005 ◽  
Vol 24 (11) ◽  
pp. 1721-1729 ◽  
Author(s):  
Daniel R. Goldstein ◽  
Scott M. Palmer
Keyword(s):  
Innate Immunity ◽  
Organ Transplantation ◽  
Toll Like Receptor ◽  
Thoracic Organ

scholarly journals The Possible Role Of Toll-Like Receptor 4 In The Pathology Of Stroke

2017 ◽  
pp. 8
Author(s):  
Mohammad Allahtavakoli ◽  
Ali Shamsizadeh ◽  
Ali Roohbakhsh ◽  
Amir Moghadam-Ahmadi ◽  
Mohammad Reza Rahmani ◽  
...  
Keyword(s):  
Innate Immunity ◽  
Inflammatory Response ◽  
System Response ◽  
Toll Like Receptor ◽  
Key Factors ◽  
Toll Like Receptor 4 ◽  
Brain Functions ◽  
Essential Components ◽  
The Impact

Stroke is a prevalent and dangerous health problem, which triggers an intense inflammatory response to Toll-like receptors (TLRs) activation. TLRs are the essential components of innate immunity system response, and therefore, they are one of the key factors involved in recognizing pathogens and internal ligands. Among TLRs, TLR4 significantly participates in the induction of inflammation and brain functions, hence, it has been hypothesized that this molecule is associated with several brain immune-related diseases such as stroke. It has also been proved that animals with TLR4 deficiency have higher protection against ischemia and the absence of TLR4 reduces the neuroinflammation and injuries associated with brain trauma. TLR4 deficiency may play a neuroprotective role in the occurrence of stroke. This article will review recent information regarding the impact of TLR4 in the pathogenicity of stroke.

scholarly journals Toll-Like Receptors in Innate Immunity: Role of Bacterial Endotoxin and Toll-Like Receptor 4 in Endometrium and Endometriosis

2009 ◽  
Vol 68 (1) ◽  
pp. 40-52 ◽  
Author(s):  
Khaleque Newaz Khan ◽  
Michio Kitajima ◽  
Koichi Hiraki ◽  
Akira Fujishita ◽  
Ichiro Sekine ◽  
...  
Keyword(s):  
Innate Immunity ◽  
Bacterial Endotoxin ◽  
Toll Like Receptor ◽  
Toll Like Receptors ◽  
Toll Like Receptor 4

Innate Immunity and Organ Transplantation: The Potential Role of Toll-like Receptors

2005 ◽  
Vol 5 (5) ◽  
pp. 969-975 ◽  
Author(s):  
Cristiano Feijo Andrade ◽  
Thomas K. Waddell ◽  
Shaf Keshavjee ◽  
Mingyao Liu
Keyword(s):  
Innate Immunity ◽  
Organ Transplantation ◽  
Potential Role ◽  
Toll Like Receptors

scholarly journals The Role of Toll-Like Receptor 2 and 4 Innate Immunity Pathways in Intracortical Microelectrode-Induced Neuroinflammation

2018 ◽  
Vol 6 ◽  
Author(s):  
John K. Hermann ◽  
Shushen Lin ◽  
Arielle Soffer ◽  
Chun Wong ◽  
Vishnupriya Srivastava ◽  
...  
Keyword(s):  
Innate Immunity ◽  
Toll Like Receptor ◽  
Toll Like Receptor 2

Role of toll‐like receptor 2 and 4 of keratocytes on corneal innate immunity

2011 ◽  
Vol 89 (s248) ◽  
pp. 0-0
Author(s):  
HJ CHOI ◽  
HJ LEE ◽  
HJ JEONG ◽  
MK KIM ◽  
WR WEE
Keyword(s):  
Innate Immunity ◽  
Toll Like Receptor ◽  
Toll Like Receptor 2

scholarly journals Maternal Vitamin D Level Is Associated with Viral Toll-Like Receptor Triggered IL-10 Response but Not the Risk of Infectious Diseases in Infancy

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Sui-Ling Liao ◽  
Shen-Hao Lai ◽  
Ming-Han Tsai ◽  
Man-Chin Hua ◽  
Kuo-Wei Yeh ◽  
...  
Keyword(s):  
Vitamin D ◽  
Innate Immunity ◽  
Infectious Diseases ◽  
Cord Blood ◽  
Vitamin D Status ◽  
Toll Like Receptor ◽  
Immune Development ◽  
Maternal Vitamin ◽  
Pregnant Mothers

Reports on the effect of prenatal vitamin D status on fetal immune development and infectious diseases in childhood are limited. The aim of this study was to investigate the role of maternal and cord blood vitamin D level in TLR-related innate immunity and its effect on infectious outcome. Maternal and cord blood 25 (OH)D level were examined from 372 maternal-neonatal pairs and their correlation with TLR-triggered TNF-α, IL-6, and IL-10 response at birth was assessed. Clinical outcomes related to infection at 12 months of age were also evaluated. The result showed that 75% of the pregnant mothers and 75.8% of the neonates were vitamin deficient. There was a high correlation between maternal and cord 25(OH)D levels (r=0.67,p<0.001). Maternal vitamin D level was inversely correlated with IL-10 response to TLR3 (p=0.004) and TLR7-8 stimulation (p=0.006). However, none of the TLR-triggered cytokine productions were associated with cord 25(OH)D concentration. There was no relationship between maternal and cord blood vitamin D status with infectious diseases during infancy. In conclusion, our study had shown that maternal vitamin D, but not cord vitamin D level, was associated with viral TLR-triggered IL-10 response.

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