scholarly journals Efficacy and safety of switching to insulin glargine 300 U/mL from 100 U/mL in Japanese patients with type 2 diabetes: A 12-month retrospective analysis

Heliyon ◽  
2019 ◽  
Vol 5 (2) ◽  
pp. e01257
Author(s):  
Kazutoshi Sugiyama ◽  
Shu Meguro ◽  
Yoshifumi Saisho ◽  
Junichiro Irie ◽  
Masami Tanaka ◽  
...  
2017 ◽  
Vol 19 (8) ◽  
pp. 1188-1192 ◽  
Author(s):  
Yasuo Terauchi ◽  
Yuichiro Yamada ◽  
Hitoshi Ishida ◽  
Mitsuru Ohsugi ◽  
Masafumi Kitaoka ◽  
...  

2014 ◽  
Vol 16 (11) ◽  
pp. 1102-1110 ◽  
Author(s):  
K. Kaku ◽  
A. Kiyosue ◽  
S. Inoue ◽  
N. Ueda ◽  
T. Tokudome ◽  
...  

2011 ◽  
Vol 4 ◽  
pp. CMED.S5976 ◽  
Author(s):  
Daisuke Yabe ◽  
Yutaka Seino

Incretin-based therapies have been gaining much attention recently as a new class of therapeutics for type 2 diabetes worldwide. Among them, glucagon-like peptide-1 receptor agonist liraglutide has been rapidly increasing its global usage. Once daily injection of liraglutide significantly ameliorates glycemic control in patients with type 2 diabetes by enhancing insulin secretion and suppressing glucagon secretion glucose-dependently. Liraglutide delays gastric emptying and suppresses food intakes, both of which contribute to glucose lowering and weight reduction. Efficacy and safety of liraglutide in management of type 2 diabetes have been well documented in several key clinical trials such as series of phase 3 Liraglutide Effect and Action in Diabetes (LEAD) trials, and the liraglutide-versus-sitagliptin trial. Recent two trials dealing with monotherapy and sulfonylurea combination therapy on Japanese patients with type 2 diabetes furthermore indicate liraglutide's effectiveness in non-obese diabetes. In this review, we summarize results from such clinical trials, and discuss efficacy and safety of liraglutide in management of type 2 diabetes in various countries, along with a pitfall of liraglutide usage in real clinical setting.


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