Neuromotor Performance in Infants Before and After Early Open Heart Surgery and Risk Factors for Delayed Development at Six Months of Age

2018 ◽  
Vol 27 ◽  
pp. S400
Author(s):  
M. Campbell ◽  
J. Ziviani ◽  
C. Stocker ◽  
A. Khan ◽  
L. Sakzewski
2019 ◽  
Vol 29 (2) ◽  
pp. 110-110
Author(s):  
Miranda J. Campbell ◽  
Jenny M. Ziviani ◽  
Christian F. Stocker ◽  
Asaduzzaman Khan ◽  
Leanne Sakzewski

2018 ◽  
Vol 29 (2) ◽  
pp. 100-109 ◽  
Author(s):  
Miranda J. Campbell ◽  
Jenny M. Ziviani ◽  
Christian F. Stocker ◽  
Asaduzzaman Khan ◽  
Leanne Sakzewski

AbstractBackgroundEarly identification of infants with CHD at heightened risk of developmental delays can inform surveillance priorities. This study investigated pre-operative and post-operative neuromotor performance in infants undergoing open-heart surgery, and their developmental status at 6 months of age, to identify risk factors and inform care pathways.MethodsInfants undergoing open-heart surgery before 4 months of age were recruited into a prospective cohort study. Neuromotor performance was assessed pre-operatively and post-operatively using the Test of Infant Motor Performance and Prechtl’s Assessment of General Movements. Development was assessed at 6 months of age using the Ages and Stages Questionnaire third edition. Pre-operative and post-operative General Movements performance was compared using McNemar’s test and test of infant motor performance z-scores using Wilcoxon’s signed rank test. Risk factors for delayed development at 6 months were explored using logistic regression.ResultsSixty infants were included in this study. In the 23 (38%) infants. A total of 60 infants were recruited. In the 23 (38%) infants assessed pre-operatively, there was no significant difference between pre- and post-operative performance on the GMs (p=0.63) or TIMP (p=0.28). At discharge, 15 (26%) infants presented with abnormal GMs, and the median TIMP z-score was −0.93 (IQR: −1.4 to −0.69). At 6 months, 28 (52.8%) infants presented with gross motor delay on the ASQ-3, significantly negatively associated with gestational age (p=0.03), length of hospital stay (p=0.04) and discharge TIMP score (p=0.01).ConclusionsPost-operative assessment using the GMs and TIMP may be useful to identify infants requiring individualised care and targeted developmental follow-up. Long-term developmental surveillance beyond 6 months of age is recommended.


2009 ◽  
Vol 67 (2b) ◽  
pp. 457-462 ◽  
Author(s):  
Taís Sica da Rocha ◽  
Ana Guardiola ◽  
Jefferson Pedro Piva ◽  
Cláudia Pires Ricachinevski ◽  
Aldemir Nogueira

There are few Brazilian studies on neuropsychomotor follow-up after open-heart surgery with circulatory bypass in infants. Twenthy infants had neurodevelopmental outcomes (neurological exam and Denver II test) assessed before open-heart surgery, after intensive care unit discharge and 3-6 months after hospital discharge. Heart lesions consisted of septal defects in 11 cases (55%). The mean circulatory bypass time was 67 ± 23.6 minutes. Fifteen infants had altered neurological examination and also neurodevelopment delay before surgery. After 6 months it was observed normalization in 6 infants. When Denver II test indexes were analysed, it was observed an improvement in all domains except personal-social. Although those infants were in risk of new neurological findings, an early improvement on neuropsychomotor indexes were seen.


2015 ◽  
Vol 10 (6) ◽  
pp. 2299-2304 ◽  
Author(s):  
GRIGORE TINICA ◽  
VERONICA MOCANU ◽  
FLORIN ZUGUN-ELOAE ◽  
DOINA BUTCOVAN

2020 ◽  
Vol 7 (8) ◽  
Author(s):  
Daniele Roberto Giacobbe ◽  
Antonio Salsano ◽  
Filippo Del Puente ◽  
Ambra Miette ◽  
Antonio Vena ◽  
...  

Abstract Background Candida species are among the most frequent causative agents of health care–associated bloodstream infections, with mortality >40% in critically ill patients. Specific populations of critically ill patients may present peculiar risk factors related to their reason for intensive care unit admission. The primary objective of the present study was to assess the predictors of candidemia after open heart surgery. Methods This retrospective, matched case–control study was conducted in 8 Italian hospitals from 2009 to 2016. The primary study objective was to assess factors associated with the development of candidemia after open heart surgery. Results Overall, 222 patients (74 cases and 148 controls) were included in the study. Candidemia developed at a median time (interquartile range) of 23 (14–36) days after surgery. In multivariable analysis, independent predictors of candidemia were New York Heart Association class III or IV (odds ratio [OR], 23.81; 95% CI, 5.73–98.95; P < .001), previous therapy with carbapenems (OR, 8.87; 95% CI, 2.57–30.67; P = .001), and previous therapy with fluoroquinolones (OR, 5.73; 95% CI, 1.61–20.41; P = .007). Crude 30-day mortality of candidemia was 53% (39/74). Septic shock was independently associated with mortality in the multivariable model (OR, 5.64; 95% CI, 1.91–16.63; P = .002). No association between prolonged cardiopulmonary bypass time and candidemia was observed in this study. Conclusions Previous broad-spectrum antibiotic therapy and high NYHA class were independent predictors of candidemia in cardiac surgery patients with prolonged postoperative intensive care unit stay.


2019 ◽  
Vol 53 (5) ◽  
pp. 226-234
Author(s):  
Michael Abdelnoor ◽  
Irene Sandven ◽  
Øystein Vengen ◽  
Ivar Risnes

1996 ◽  
Vol 76 ◽  
pp. 4-5
Author(s):  
S. Garrido ◽  
M.J. Martín ◽  
S. Rodiño ◽  
J. Llorens ◽  
C.R. Valdés ◽  
...  

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