Quantum: patient reported outcomes (PROs) after minimal access retroperitoneal pancreatic necrosectomy to treat acute pancreatitis – An exploratory study

Introduction: Patient-reported outcomes (PROs) can help clinicians better evaluate chemotherapy and immunotherapy toxicity based on patient perspectives. In this exploratory study, we tested a simplified PRO questionnaire (sPQ) in routine clinical practice and patient satisfaction with this tool. Methods: We included 16 items related to the main toxicities of chemotherapy and immunotherapy to be filled in by patients. A baseline sPQ was completed by patients before starting treatment and then in the interval between courses for a total of 4 sPQs. Patients communicated the results to a data manager, who alerted the referral oncologist in case of replies differing from the basal or previous sPQ. According to the severity of symptoms, the patient was then referred to the team nurse, the general practitioner, or another specialist. A satisfaction survey was also completed. Results: In a 3-month interval, 27 patients were enrolled. Fatigue and nausea were the most frequent symptoms reported as worsening during treatment. The oncologist was involved in the management of adverse events in 4 cases, home therapy variations were recommended by the dedicated nurse in 14 cases, additional visits were performed in 6 patients, and 1 patient was admitted to the oncology ward. None of the patients had unplanned visits to the emergency department or to the hospital. The sPQ was judged to be simple, useful, and satisfactory. Conclusions: Using sPQs in routine clinical practice was feasible and well-accepted by patients. PROs allowed us to recognize and promptly manage adverse events, reducing unplanned emergency department or hospital visits to zero.

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Characteristics and patient-reported outcomes associated with dropout in severely affected oncological patients: an exploratory study

BMC Medical Research Methodology ◽

10.1186/s12874-021-01259-0 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Pimrapat Gebert ◽

Daniel Schindel ◽

Johann Frick ◽

Liane Schenk ◽

Ulrike Grittner

Keyword(s):

Quality Of Life ◽

Social Support ◽

Exploratory Study ◽

Patient Reported Outcomes ◽

Drop Out ◽

Health Related Quality ◽

Patient Reported ◽

Related Quality ◽

Health Related

Abstract Background Patient-reported outcome measures (PROMs) are commonly-used surrogates for clinical outcomes in cancer research. When researching severe diseases such as cancer, it is difficult to avoid the problem of incomplete questionnaires from drop-outs or missing data from patients who pass away during the observation period. The aim of this exploratory study was to explore patient characteristics and the patient-reported outcomes associated with the time-to-dropout. Methods In an Oncological Social Care Project (OSCAR) study, the condition of the participants was assessed four times within 12 months (t0: baseline, t1: 3 months, t2: 6 months, and t3: 12 months) by validated PROMs. We performed competing-risk regressions based on Fine and Gray’s proportional sub-distribution hazards model for exploring factors associated with time-to-dropout. Death was considered a competing risk. Results Three hundred sixty-two participants were analyzed in the study. 193 (53.3%) completed a follow-up after 12 months, 67 (18.5%) patients dropped out, and 102 patients (28.2%) died during the study period. Poor subjective social support was related to a higher risk of drop-out (SHR = 2.10; 95%CI: 1.01–4.35). Lower values in health-related quality of life were related to drop-out and death. The sub-scales global health status/QoL, role functioning, physical functioning, and fatigue symptom in the EORTC QLQ-C30 were key characteristics of early drop-out. Conclusion Severely affected cancer patients with poor social support and poor quality of life seem more likely to drop out of studies than patients with higher levels of social support and a better quality of life. This should be considered when planning studies to assess advanced cancer patients. Methods of close continued monitoring should be actively used when patient experiences a substantial deterioration in their health-related quality of life and symptoms during the study. Results for such studies have to be interpreted with caution in light of specific drop-out mechanisms. Trial registration OSCAR study was registered to the German Clinical Trials Register (DRKS-ID: DRKS00013640). Registered 29 December 2017.

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Sa1007 PATIENT-REPORTED OUTCOMES AND QUALITY OF LIFE DURING AND AFTER FIRST EPISODE OF ACUTE PANCREATITIS: ANALYSIS OF THE INTERNATIONAL MULTICENTER PROSPECTIVE PAN-PROMISE STUDY

Gastroenterology ◽

10.1016/s0016-5085(20)31283-x ◽

2020 ◽

Vol 158 (6) ◽

pp. S-239

Author(s):

Ayesha Kamal ◽

Venkata S. Akshintala ◽

Serhii Chuklin ◽

Víctor Jiménez-Beltrán ◽

Rita Martins ◽

...

Keyword(s):

Quality Of Life ◽

Acute Pancreatitis ◽

Patient Reported Outcomes ◽

First Episode ◽

Patient Reported ◽

International Multicenter

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Prevalence of Chronic Metabolic Comorbidities in Acute Pancreatitis and Its Impact on Early Gastrointestinal Symptoms during Hospitalization: A Prospective Cohort Study

Biomedicine Hub ◽

10.1159/000519826 ◽

2021 ◽

pp. 111-117

Author(s):

Rachel Goodger ◽

Kanageswari Singaram ◽

Maxim S. Petrov

Keyword(s):

Diabetes Mellitus ◽

Metabolic Syndrome ◽

Acute Pancreatitis ◽

Cohort Study ◽

Abdominal Pain ◽

Prospective Cohort ◽

Patient Reported Outcomes ◽

Gastrointestinal Symptoms ◽

Patient Reported ◽

Metabolic Comorbidities

Background: The prevalence of chronic comorbidities is increasing worldwide, and this has been paralleled by a growing interest in how these comorbidities affect patients with acute pancreatitis. The aim was to investigate the associations between pre-existing diabetes mellitus, obesity, metabolic syndrome, and gastrointestinal symptoms during the early course of acute pancreatitis. Methods: This was a prospective cohort study of patients with a primary diagnosis of acute pancreatitis. Study groups were formed based on the presence of metabolic comorbidities (pre-existing diabetes mellitus, obesity, and metabolic syndrome). Patient-reported outcomes (nausea, bloating, and abdominal pain) were collected prospectively every 24 h (including weekends and public holidays) over the first 72 h of hospitalization. Results: A total of 183 consecutive patients were enrolled. Of them, 111 (61%) had at least one major metabolic comorbidity. Patients with pre-existing diabetes mellitus and those with metabolic syndrome had worse nausea at 49–72 h of hospitalization (p = 0.017 and p = 0.012, respectively), but not at other time points. Bloating and abdominal pain did not differ between the study groupings throughout the study period. The studied patient-reported outcomes did not differ significantly between acute pancreatitis patients with and without obesity at any point in time. Conclusion: More than 3 out of 5 patients hospitalized for acute pancreatitis have at least one major chronic metabolic comorbidity. The presence of metabolic comorbidities does not considerably and consistently affect early gastrointestinal symptoms in patients with acute pancreatitis.

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