Primary low-grade fibromyxoid sarcoma of the breast: a rare case report with immunohistochemical and fluorescence in situ hybridization detection

2018 ◽  
Vol 79 ◽  
pp. 208-211 ◽  
Author(s):  
Yutao Zhang ◽  
Dan Wan ◽  
Fuping Gao
Keyword(s):  
In Situ Hybridization ◽  
Case Report ◽  
Fluorescence In Situ Hybridization ◽  
Rare Case ◽  
Low Grade ◽  
Rare Case Report ◽  
Fibromyxoid Sarcoma ◽  
Hybridization Detection

scholarly journals Low-grade fibromyxoid sarcoma around the knee involving the proximal end of the tibia and patella: A rare case report

2014 ◽  
Vol 7 (4) ◽  
pp. 1308-1312 ◽  
Author(s):  
JEETENDRA BAJPAI ◽  
SAURAV SHUKLA ◽  
MOAZZAM JAH ◽  
ALOK KUMAR SINGH ◽  
MOHIT GOEL ◽  
...  
Keyword(s):  
Case Report ◽  
Rare Case ◽  
Low Grade ◽  
Rare Case Report ◽  
Fibromyxoid Sarcoma

scholarly journals Low-grade fibromyxoid sarcoma of a male breast – a uniquely rare case report

2021 ◽  
Author(s):  
Agnieszka Niepokój-Czopnik ◽  
Michał Aporowicz ◽  
Łukasz Hałoń ◽  
Adam Maciejczyk ◽  
Rafał Matkowski
Keyword(s):  
Case Report ◽  
Rare Case ◽  
Male Breast ◽  
Low Grade ◽  
Rare Case Report ◽  
Fibromyxoid Sarcoma

FUS (16p11) Gene Rearrangement as Detected by Fluorescence In-Situ Hybridization in Cutaneous Low-Grade Fibromyxoid Sarcoma: A Potential Diagnostic Tool

2011 ◽  
Vol 33 (2) ◽  
pp. 140-143 ◽  
Author(s):  
Rajiv M Patel ◽  
Erinn Downs-Kelly ◽  
Monisha N Dandekar ◽  
Julie C Fanburg-Smith ◽  
Steven D Billings ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
Fluorescence In Situ Hybridization ◽  
Diagnostic Tool ◽  
Gene Rearrangement ◽  
Low Grade ◽  
Fibromyxoid Sarcoma

scholarly journals Low Grade Fibromyxoid Sarcoma in Oral Cavity: A Rare Case Report

2015 ◽  
Vol 71 (S1) ◽  
pp. 25-26
Author(s):  
T. Kanato ◽  
S. Kalyani ◽  
T. Lailyang ◽  
D. Santosh ◽  
T. Rebecca ◽  
...  
Keyword(s):  
Case Report ◽  
Oral Cavity ◽  
Rare Case ◽  
Low Grade ◽  
Rare Case Report ◽  
Fibromyxoid Sarcoma

scholarly journals Low-grade fibromyxoid sarcoma: A rare case report

2021 ◽  
Vol 12 (2) ◽  
pp. 271
Author(s):  
VinayakGourish Naik ◽  
KirthiKumar Rai ◽  
HR Shivakumar
Keyword(s):  
Case Report ◽  
Rare Case ◽  
Low Grade ◽  
Rare Case Report ◽  
Fibromyxoid Sarcoma

Peripheral nerve fibromyxoid sarcoma

2014 ◽  
Vol 121 (3) ◽  
pp. 576-579 ◽  
Author(s):  
Raanan Y. Alter ◽  
Christina C. Wamsley ◽  
John T. Mullen ◽  
Winta Z. Haile ◽  
Jeffrey D. Goldsmith ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
Soft Tissue ◽  
Peripheral Nerve ◽  
Fluorescence In Situ Hybridization ◽  
Clinical Symptoms ◽  
Hybridization Analysis ◽  
Low Grade ◽  
Fibromyxoid Sarcoma

Low-grade fibromyxoid sarcoma (LGFMS) is a rare soft-tissue neoplasm with metastatic potential and needs to be recognized as such, because it can be mistaken for other types of sarcoma due to its unremarkable appearance. This 49-year-old man presented with an approximately 5-cm mass on the anteromedial aspect of his left thigh that slowly increased over 10 years. Clinical symptoms were limited to local discomfort and intermittent distal numbness. Due to the location, imaging findings, and lack of serious symptoms, the initial differential diagnosis favored a schwannoma. An initial biopsy revealed histopathological findings consistent with a perineurioma, although with atypical features. The patient elected to have the mass excised, and the tumor, which arose from a branch of the saphenous nerve, could be separated well from the surrounding soft tissue. Histopathological investigation of the mass displayed characteristic features of a fibromyxoid sarcoma, which was confirmed by subsequent fluorescence in situ hybridization analysis. Due to concerns about infiltration beyond the margins, radical reexcision was advocated and performed, resulting in definite clear surgical margins. At follow-up, the patient had regained full strength with no residual neurological symptoms or any new deficits. He has since been healthy and disease free for a total of 4 years in follow-up. This case documents, to the authors' knowledge, the first observation of an LGFMS associated with a peripheral nerve. It also supports the use of fluorescence in situ hybridization analysis as an essential diagnostic method in establishing the diagnosis of LGFMS.

Canine Hepatitis Associated with Intrahepatic Bacteria in Three Dogs

2018 ◽  
Vol 54 (1) ◽  
pp. 65-70 ◽  
Author(s):  
Joon Im ◽  
Derek P. Burney ◽  
Sean P. McDonough ◽  
Brigid Nicholson ◽  
Adam Eatroff ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
Case Report ◽  
Fluorescence In Situ Hybridization ◽  
Antimicrobial Therapy ◽  
Granulomatous Inflammation ◽  
Formalin Fixed Paraffin ◽  
Formalin Fixed Paraffin Embedded ◽  
Hematoxylin And Eosin ◽  
Formalin Fixed

ABSTRACT This case report describes the detection of intrahepatic bacteria in formalin-fixed paraffin-embedded histopathological sections from three dogs with neutrophilic, pyogranulomatous, or lymphoplasmacytic hepatitis and cholangiohepatitis. In each of these cases, eubacterial fluorescence in situ hybridization enabled colocalization of intrahepatic bacteria with neutrophilic and granulomatous inflammation in samples that were negative for bacteria when evaluated by routine hematoxylin and eosin histopathology augmented with histochemical stains. Positive responses to antimicrobial therapy were observed in of 2 out of 2 patients that were treated with antimicrobials. These findings suggest that eubacterial fluorescence in situ hybridization analysis of formalin-fixed paraffin-embedded histopathological sections is more sensitive than conventional histochemical stains for the diagnosis of bacteria-associated canine hepatitis.

scholarly journals Urachal yolk sac tumor penetrating the bladder as a diagnostic challenge: a case report and review of the literature

2022 ◽  
Vol 17 (1) ◽  
Author(s):  
Vladimír Šámal ◽  
Tomáš Jirásek ◽  
Vít Paldus ◽  
Igor Richter ◽  
Ondřej Hes
Keyword(s):  
Case Report ◽  
Rare Case ◽  
Yolk Sac ◽  
Cell Tumor ◽  
Yolk Sac Tumor ◽  
Review Of The Literature ◽  
Diagnostic Challenge ◽  
Macroscopic Hematuria ◽  
Rare Case Report

Abstract Background Yolk sac tumor (YST) is a germ cell tumor. It is primarily located in the gonads but can also occur extragonadally (extragonadal yolk sac tumor - EGYST), most commonly in the pelvis, retroperitoneum or mediastinum. Only a few YSTs of the urachus have been described. Case report We present a rare case report of a 37-year-old male with episodes of macroscopic hematuria. The histological specimen obtained by transurethral resection showed a solid, and in some parts papillary infiltrative, high-grade tumor with numerous areas of marked nuclear atypia and clear invasion between the detrusor bundles. Glandular pattern has been observed in only minority of the tumor. Immunohistochemistry showed significant positivity for GPC3, SALL4 and cytokeratins AE1/AE3, while KRT7 and GATA3 were negative. We concluded that the biopsy findings were consistent with urothelial carcinoma with infrequent YST differentiation. In definitive surgical specimens we found a malignant epithelial, glandular and cystically arranged tumor of germinal appearance arising from urachus. The surrounding urothelium was free of invasive or in situ tumor changes. We reclassified the tumor as a urachal YST. Conclusion EGYST was suspected because glandular and hepatoid structures were found, but the presence of these structures should be verified by immunohistochemistry.

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