Abstract
Background: The clinical manifestation of coronavirus disease 2019 (COVID-19) overlap with other disorders especially cardiovascular diseases (CVD). The prevailing conditions in the COVID-19 pandemic can distract us from other differential diagnoses.Case presentation: We report a 58 years old female presented with syncope episodes and dyspnea on exertion (DOE) with the left atrial (LA) mass, candidate for surgical removal and mitral valve replacement. Nearly 3 months later, she developed dyspnea, fever, and a sore throat cause to admit her with suspected COVID-19. During diagnostic evaluation, a larger LA mass detected that seemed to be COVID-19 induced organized thrombus with prosthetic mitral valve malfunction. The mass resected and immunohistochemistry revealed liposarcoma.Conclusions: The unusual early recurrence of liposarcoma and misdiagnosis with COVID-19 induced thrombosis is the hallmark of the present case that we keep other causes in mind besides COVID-19.