Design of a pH-sensitive magnetic composite hydrogel based on salecan graft copolymer and Fe3O4@SiO2 nanoparticles as drug carrier

2018 ◽  
Vol 107 ◽  
pp. 1811-1820 ◽  
Author(s):  
Xinyu Hu ◽  
Yongmei Wang ◽  
Liangliang Zhang ◽  
Man Xu ◽  
Jianfa Zhang ◽  
...  
Keyword(s):  
Graft Copolymer ◽  
Drug Carrier ◽  
Sio2 Nanoparticles ◽  
Ph Sensitive ◽  
Composite Hydrogel ◽  
Magnetic Composite

Synthesis of Au/SiO2 Nanoparticles with Highly Porous Structure as a pH-Sensitive Targeting Drug Carrier

2017 ◽  
Vol 28 (1) ◽  
pp. 187-194
Author(s):  
Reza Rahmatolahzadeh ◽  
Masood Hamadanian ◽  
Hamidreza Shagholani ◽  
Seyed Reza Moosavikia
Keyword(s):  
Porous Structure ◽  
Drug Carrier ◽  
Sio2 Nanoparticles ◽  
Ph Sensitive ◽  
Highly Porous

Hollow poly(MPC-g-PEG-b-PLA) graft copolymer microcapsule as a potential drug carrier

2012 ◽  
Vol 29 (3) ◽  
pp. 242-249 ◽  
Author(s):  
Chaoyong Liu ◽  
Lixia Long ◽  
Zhi Li ◽  
Bin He ◽  
Liuheng Wang ◽  
...  
Keyword(s):  
Graft Copolymer ◽  
Drug Carrier ◽  
Potential Drug

Synthesis and characterization of an amphiphilic graft polymer and its potential as a pH-sensitive drug carrier

Polymer ◽  
2011 ◽  
Vol 52 (15) ◽  
pp. 3304-3310 ◽  
Author(s):  
Yi Li ◽  
Hye Jung Heo ◽  
Guang Hui Gao ◽  
Seong Woo Kang ◽  
Cong Truc Huynh ◽  
...  
Keyword(s):  
Drug Carrier ◽  
Ph Sensitive ◽  
Synthesis And Characterization ◽  
Graft Polymer

scholarly journals Carboxymethyl cellulose-grafted graphene oxide for efficient antitumor drug delivery

2018 ◽  
Vol 7 (4) ◽  
pp. 291-301 ◽  
Author(s):  
Zepeng Jiao ◽  
Bin Zhang ◽  
Chunya Li ◽  
Weicong Kuang ◽  
Jingxian Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Drug Delivery System ◽  
Delivery System ◽  
Carboxymethyl Cellulose ◽  
Drug Carrier ◽  
Controlled Drug Release ◽  
Ph Sensitive ◽  
Tumor Growth Inhibition

Abstract A drug delivery system based on carboxymethyl cellulose-grafted graphene oxide loaded by methotrexate (MTX/CMC-GO) with pH-sensitive and controlled drug-release properties was developed in this work. CMC was grafted on graphene oxide by ethylenediamine through hydrothermal treatment. CMC serves as a pH-sensitive trigger, while CMC-GO serves as a drug-carrying vehicle due to the curved layer and large plain surface. Different amounts of drugs could be loaded into CMC-GO nanocarriers by control of the original amount of drug/carrier ratios. Additionally, low cytotoxicity against NIH-3T3 cells and low in vivo toxicity was observed. In vivo tumor growth inhibition assays showed that MTX/CMC-GO demonstrated superior antitumor activity than free MTX against HT-29 cells. Moreover, prolonged survival time of mice was observed after MTX/CMC-GO administration. The MTX/CMC-GO drug delivery system has a great potential in colon cancer therapy.

scholarly journals Composite Hydrogel Embedded with Porous Microspheres for Long-Term pH-Sensitive Drug Delivery

2019 ◽  
Vol 25 (3-4) ◽  
pp. 172-182 ◽  
Author(s):  
Xifeng Liu ◽  
Kevin A. Fundora ◽  
Zifei Zhou ◽  
Alan Lee Miller ◽  
Lichun Lu
Keyword(s):  
Drug Delivery ◽  
Ph Sensitive ◽  
Composite Hydrogel ◽  
Porous Microspheres
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