Amide-Linked Dendron-based Amphiphiles: A class of pH sensitive and highly biocompatible drug carrier for sustained drug release

The development of antimicrobial materials with sustained drug release performance is of great importance. Graphene oxide (GO) is considered to be an ideal drug carrier. In this study, tetracycline hydrochloride (TC) was loaded onto polyethyleneimine-functionalized GO (PG) to fabricate TC/PG nanocomposites. The success of the fabrication was confirmed by zeta potential, TEM, FTIR, and Raman analyses. The TC/PG nanocomposites showed a controlled and sustained drug release behavior, and a pseudo second order kinetic model was employed to illustrate the release mechanism. The antibacterial activity was studied using the disk diffusion method against Escherichia coli and Staphylococcus aureus. The TC/PG nanocomposites exhibited great bacterial inhibition performance. The results indicate that the fabricated TC/PG nanocomposites with effective antibacterial activity have great potential in antibacterial applications.

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THE DRUG RELEASE FROM LIPOSOMAL CARRIER WITHIN THE CHITOSAN MATRIX

Biomedical Engineering Applications Basis and Communications ◽

10.4015/s1016237209001167 ◽

2009 ◽

Vol 21 (02) ◽

pp. 107-114 ◽

Cited By ~ 4

Author(s):

Hongsen Chiang ◽

Yi-Cheng Huang ◽

Huei-Yu Yeh ◽

Szu-Yi Yeh ◽

Yi-You Huang

Keyword(s):

Drug Release ◽

Tissue Regeneration ◽

Drug Carrier ◽

Sustained Drug Release ◽

Hydrophilic Drugs ◽

Chitosan Matrix ◽

Injectable Scaffold ◽

Regulation Of Growth ◽

Carrier Systems ◽

Drug Carrier Systems

The release and regulation of growth factors are very important in the tissue regeneration. Optimal and suitable drug carrier systems combined with scaffold are needed to be exploited. In this study, we developed an injectable scaffold incorporated with drug release system for tissue regeneration. Hydrophilic or hydrophobic drugs can be encapsulated into liposomes and then dispersed in the temperature-reversible chitosan-glycerophosphate (GP) hydrogel. Experimental results show that liposomes provide excellent sustained drug release from chitosan matrix when compared with that of free drugs, especially for hydrophilic drugs. The negative charge of the liposome will complex with the positive charge of the chitosan's protonized amine group that results in controlling the drugs release.

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Nanocomposite Multilayer Fibrous Membrane for Sustained Drug Release

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.894.364 ◽

2014 ◽

Vol 894 ◽

pp. 364-368 ◽

Cited By ~ 1

Author(s):

Ahmed Hassanin ◽

Ahmed A. El-Moneim ◽

Mohamed Ghaniem ◽

Hassan Nageh

Keyword(s):

Drug Release ◽

Outer Layer ◽

Biomedical Application ◽

Drug Carrier ◽

Electrospun Nanofibers ◽

Drug Release Profile ◽

Sustained Drug Release ◽

Sem Images ◽

Fibrous Membranes ◽

The Many

Building on the success of the many earlier studies on electrospun nanofibers technique which provide a non woven web to the order of nanometers introducing superior properties such as large surface area, superior mechanical properties and ease of implementation in many fields of applications, elctrospun nanofibers became an important issue for many researchers in various fields. Using elctrospun fibers as a drug carrier, is showing a huge promising potential for the future of biomedical application. Our work in this research is focusing on engineering a system to control the drug release profile rate especially for wound dressing. Nanocomposite multilayer fibrous membranes, using electrospinning method, have been developed for drug release in form of sandwich structure of three layers. Inner layer which is kept Polycaprolactane (PCL) loaded with drug. The two outer layers have been changed with different blend ratios between Chitosan (Cs) and PCL as follow [0%:100% Cs:PCL, 30%:70% Cs:PCL, 50%:50% Cs:PCL, 70%:30% Cs:PCL]. The results showed that the release rate has been affected dramatically by the outer layer composition. SEM images showed changing in the morphology due to the different in the composition of outer layer.

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Synthesis and characterization of oral drug delivery, a pH – sensitive silver nanocomposite based on sodium alginate extracted from Sargassum asperifolium collected from Jazan coasts, KSA

10.1101/557231 ◽

2019 ◽

Author(s):

Fatimah. A. Agili ◽

Sahera. F. Mohamed

Keyword(s):

Electron Microscope ◽

Drug Release ◽

Sodium Alginate ◽

Oral Drug Delivery ◽

Drug Carrier ◽

Gastric Fluid ◽

Ph Sensitive ◽

Oral Drug ◽

Release Mechanism ◽

X Ray

AbstractThe pH-sensitive nanocomposite composed of sodium alginate/ Pectin/ Tannic acid – silver SA/Pec/TA-Ag was prepared using microwave irradiation and employed as a carrier for Propranolol drug. Physico-chemical characteristics of the prepared systems using Fourier Transform Infrared Spectroscopy (FTIR), X-ray Diffraction (XRD), Field Emission Scanning Electron Microscope (FESEM), High-Resolution Transmission Electron Microscope (HRTEM), Dynamic light Scattering instrument (DLS), and Energy Dispersive X-Ray Analysis (EDX). The percentage drug release was 96% at pH 7.4 within 420 min. The drug release data was fitted into different kinetic models included zero order, First order, Higuchi and Ritger-Peppas model. The release mechanism is non-Fickian character where it controlled by diffusion and relaxation of polymer chains. It can be concluded that SA/Pec/TA-Ag nanocomposite is candidate for the oral drug carrier specific for intestinal system and has stability against gastric fluid.

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Physicochemical characterization and release properties of oral drug delivery: A pH-sensitive nanocomposite based on sodium alginate–pectin–tannic acid–silver

Polymers and Polymer Composites ◽

10.1177/0967391119895073 ◽

2019 ◽

Vol 28 (8-9) ◽

pp. 598-608

Author(s):

Fatimah A Agili ◽

Sahera FM Aly

Keyword(s):

Electron Microscope ◽

Drug Release ◽

Sodium Alginate ◽

Tannic Acid ◽

Drug Carrier ◽

Ph Sensitive ◽

Diffraction Field ◽

Oral Drug ◽

Release Mechanism ◽

X Ray

A pH-sensitive nanocomposite formed from sodium alginate (SA)/pectin (Pec)/tannic acid (TA)–silver (Ag) was developed using microwave irradiation and it was applied as a carrier for propranolol drug. TA acts as a cross-linker and a reducing agent for Ag ions. Physicochemical characteristics of the fabricated system using Fourier transform infrared spectroscopy, X-ray diffraction, field-emission scanning electron microscope, high-resolution transmission electron microscope, dynamic light scattering instrument, and energy dispersive X-ray analysis. The swelling percent and the drug release were observed to be pH-sensitive. The occurrence of Ag nanoparticles in the network enhances the drug release that is 96% at pH 7.4 within 420 min. The drug release data were adjusted into different kinetic models involved zero order, first order, Higuchi, and Ritger–Peppas models. The release mechanism is a non-Fickian character where it controls by diffusion and relaxation of polymer chains. It can be concluded that SA/Pec/TA-Ag nanocomposite is a candidate for the oral drug carrier specific for the intestinal system and has ability against the gastric fluid.

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Polypeptides Micelles Composed of Methoxy-Poly(Ethylene Glycol)-Poly(l-Glutamic Acid)-Poly(l-Phenylalanine) Triblock Polymer for Sustained Drug Delivery

Pharmaceutics ◽

10.3390/pharmaceutics10040230 ◽

2018 ◽

Vol 10 (4) ◽

pp. 230 ◽

Cited By ~ 2

Author(s):

Xingzheng Liu ◽

Rongrong Fan ◽

Boting Lu ◽

Yuan Le

Keyword(s):

Drug Release ◽

Ethylene Glycol ◽

Glutamic Acid ◽

Drug Carrier ◽

Drug Loading ◽

Poly Ethylene Glycol ◽

Sustained Drug Release ◽

Poly Ethylene ◽

Triblock Polymers

Methoxy-poly(ethylene glycol)-poly(l-glutamic acid)-poly(l-phenylalanine) triblock polymers with different architecture were synthesized as drug carrier to obtain sustained and controlled release by tuning the composition. These triblock polymers were prepared by ring opening polymerization and poly(ethylene glycol) was used as an initiator. Polymerization was confirmed by 1H NMR, FT-IR and gel penetration chromatography. The polymers can self-assemble to form micelles in aqueous medium and their critical micelle concentrations values were examined. The micelles were spherical shape with size of 50–100 nm and especially can arranged in a regular manner. Sorafenib was selected as the model drug and the drug loading performance was dependent on the composition of the block copolymer. In vitro drug release indicated that the polymers can realize controlled and sustained drug release. Furthermore, in vitro cytotoxicity assay showed that the polymers were biocompatible and the drug-loaded micelles can increase toxicity towards tumor cells. Confocal fluorescence microscopy assays illustrated that the micelles can be uptaken quickly and release drug persistently to inhibit tumor cell growth.

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pH-Sensitive N-doped carbon dots–heparin and doxorubicin drug delivery system: preparation and anticancer research

RSC Advances ◽

10.1039/c6ra28345d ◽

2017 ◽

Vol 7 (15) ◽

pp. 9347-9356 ◽

Cited By ~ 29

Author(s):

Ming Zhang ◽

Ping Yuan ◽

Ninglin Zhou ◽

Yutian Su ◽

Maoni Shao ◽

...

Keyword(s):

Drug Delivery ◽

Drug Release ◽

Drug Delivery System ◽

Delivery System ◽

Carbon Dots ◽

Drug Carrier ◽

Ph Sensitive ◽

Triggered Drug Release ◽

Model Drug ◽

Doped Carbon Dots

In this study, doxorubicin (DOX) hydrochloride as a model drug, N-doped carbon dots as a drug carrier, and heparin as an auxiliary medicine were selected to design and prepare a multi-functional drug delivery system with pH-triggered drug release.

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Polypyrrole nanoparticles for tunable, pH-sensitive and sustained drug release

Nanoscale ◽

10.1039/c5nr02196k ◽

2015 ◽

Vol 7 (21) ◽

pp. 9497-9504 ◽

Cited By ~ 47

Author(s):

Devleena Samanta ◽

Jana L. Meiser ◽

Richard N. Zare

Keyword(s):

Drug Release ◽

Ph Sensitive ◽

Sustained Drug Release ◽

Drug Molecules ◽

Polypyrrole Nanoparticles

Charged drug molecules from nanoparticles are released by changing the pH of the surroundings and fine-tuned by adding appropriate amphiphiles.

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An Environmentally Sensitive Silk Fibroin/Chitosan Hydrogel and Its Drug Release Behaviors

Polymers ◽

10.3390/polym11121980 ◽

2019 ◽

Vol 11 (12) ◽

pp. 1980 ◽

Cited By ~ 1

Author(s):

Zhangpeng Xu ◽

Erni Tang ◽

Huijing Zhao

Keyword(s):

Drug Release ◽

Internal Structure ◽

Silk Fibroin ◽

Mechanical Performance ◽

Drug Carrier ◽

Ion Concentration ◽

Compression Tests ◽

Sustained Drug Release ◽

Sem Images ◽

Environmentally Sensitive

To fabricate environmentally sensitive hydrogels with better biocompatibility, natural materials such as protein and polysaccharide have been widely used. Environmentally sensitive hydrogels can be used as a drug carrier for sustained drug release due to its stimulus responsive performance. The relationship between the internal structure of hydrogels and their drug delivery behaviors remains indeterminate. In this study, environmentally sensitive hydrogels fabricated by blending silk fibroin/chitosan with different mass ratios were successfully prepared using 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide (EDC)/N-Hydroxysuccinimide (NHS) cross-linking agent. Scanning-electron microscopy (SEM) images showed the microcosmic surface of the gel had a 3-D network-like and interconnected pore structure. The N2 adsorption–desorption method disclosed the existence of macroporous and mesoporous structures in the internal structure of hydrogels. Data of compression tests showed its good mechanical performance. The swelling performance of hydrogels exhibited stimuli responsiveness at different pH and ion concentration. With the increase of pH and ion concentration, the swelling ratios of hydrogels (silk fibroin (SF)/ chitosan (CS) = 8/2 and 7/3) decreased. Methylene blue (MB) was loaded into the hydrogels to confirm the potential of sustained drug release and pH-responsive behavior. Therefore, due to the porous structure, stable mechanical strength, stimuli responsive swelling performance, and drug release behaviors, the SF/CS composite hydrogels have potential applications in controlled drug release.

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pH-Sensitive Polyampholyte Microgels of Poly(Acrylic Acid-co-Vinylamine) as Injectable Hydrogel for Controlled Drug Release

Polymers ◽

10.3390/polym11020285 ◽

2019 ◽

Vol 11 (2) ◽

pp. 285 ◽

Cited By ~ 9

Author(s):

Yanmin Chen ◽

Peijian Sun

Keyword(s):

Drug Release ◽

Acrylic Acid ◽

Zeta Potential ◽

Suspension Polymerization ◽

Controlled Drug Release ◽

Ph Sensitive ◽

Swelling Ratio ◽

Sustained Drug Release ◽

Injectable Hydrogel ◽

Poly Acrylic Acid

pH-sensitive polyampholyte microgels of poly(acrylic acid-co-vinylamine) (P(AA-co-VAm)) were developed as an injectable hydrogel for controlled drug release. The microgels of P(AA-co-VAm) were prepared via inverse suspension polymerization of acrylic acid and N-vinylformamide followed by hydrolysis of poly(N-vinylformamide) (PNVF) chains of the resultant microgels under basic condition. The pH-sensitivity of the P(AA-co-VAm) microgels in zeta potential and swelling ratio were investigated using a zeta potential analyzer and optical microscope. The results showed that both the zeta potential and the swelling ratio of the microgels were highly affected by the solution pH. By changing the pH of P(AA-co-VAm) microgel dispersion, the interparticle interaction and the swelling ratio of the microgels could be well adjusted and a colloidal hydrogel could be fabricated at moderate pH, showing a pH-triggered reversible fluid-gel transition. Using the polyampholyte P(AA-co-VAm) microgels as an injectable hydrogel drug release system, a sustained drug release could be achieved, indicating the great potentials of the pH-sensitive P(AA-co-VAm) microgels for controlled drug delivery.

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