Biophysical insight into the interaction mechanism of plant derived polyphenolic compound tannic acid with homologous mammalian serum albumins

2018 ◽  
Vol 107 ◽  
pp. 2450-2464 ◽  
Author(s):  
Mohd Ishtikhar ◽  
Ejaz Ahmad ◽  
Zeba Siddiqui ◽  
Shafeeque Ahmad ◽  
Mohsin Vahid Khan ◽  
...  
Keyword(s):  
Tannic Acid ◽  
Interaction Mechanism ◽  
Polyphenolic Compound ◽  
Serum Albumins ◽  
Insight Into

Insight into the tannic acid-based modular-assembly strategy based on inorganic–biological hybrid systems: a material suitability, loading effect, and biocompatibility study

2021 ◽  
Author(s):  
Xiaoning Ren ◽  
Panqing Yin ◽  
Jun Liang ◽  
Xiangjian Liu ◽  
Wugen Zhan ◽  
...  
Keyword(s):  
Hybrid Systems ◽  
Tannic Acid ◽  
Modular Assembly ◽  
Loading Effect ◽  
Assembly Strategy ◽  
Biocompatibility Study ◽  
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The tannic acid-based modular-assembly strategy for building inorganic–biological hybrids is studied regarding the aspects of the material suitability, loading effect, and biocompatibility.

scholarly journals Interaction of 2′R-ochratoxin A with Serum Albumins: Binding Site, Effects of Site Markers, Thermodynamics, Species Differences of Albumin-binding, and Influence of Albumin on Its Toxicity in MDCK Cells

Toxins ◽  
2018 ◽  
Vol 10 (9) ◽  
pp. 353 ◽  
Author(s):  
Zelma Faisal ◽  
Diána Derdák ◽  
Beáta Lemli ◽  
Sándor Kunsági-Máté ◽  
Mónika Bálint ◽  
...  
Keyword(s):  
Binding Site ◽  
Ochratoxin A ◽  
Mdck Cells ◽  
Binding Constants ◽  
Albumin Binding ◽  
Serum Albumins ◽  
Site Markers ◽  
Fetal Bovine ◽  
Toxic Concentrations ◽  
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Ochratoxin A (OTA) is a nephrotoxic mycotoxin. Roasting of OTA-contaminated coffee results in the formation of 2′R-ochratoxin A (2′R-OTA), which appears in the blood of coffee drinkers. Human serum albumin (HSA) binds 2′R-OTA (and OTA) with high affinity; therefore, albumin may influence the tissue uptake and elimination of ochratoxins. We aimed to investigate the binding site of 2′R-OTA (verses OTA) in HSA and the displacing effects of site markers to explore which molecules can interfere with its albumin-binding. Affinity of 2′R-OTA toward albumins from various species (human, bovine, porcine and rat) was tested to evaluate the interspecies differences regarding 2′R-OTA-albumin interaction. Thermodynamic studies were performed to give a deeper insight into the molecular background of the complex formation. Besides fluorescence spectroscopic and modeling studies, effects of HSA, and fetal bovine serum on the cytotoxicity of 2′R-OTA and OTA were tested in MDCK kidney cell line in order to demonstrate the influence of albumin-binding on the cellular uptake of ochratoxins. Site markers displaced more effectively 2′R-OTA than OTA from HSA. Fluorescence and binding constants of 2′R-OTA-albumin and OTA-albumin complexes showed different tendencies. Albumin significantly decreased the cytotoxicity of ochratoxins. 2′R-OTA, even at sub-toxic concentrations, increased the toxic action of OTA.

Spectroscopic and theoretical calculation insight into interaction mechanism between U(VI) and phospholipid under carbonate environment

2020 ◽  
Vol 305 ◽  
pp. 112852 ◽  
Author(s):  
Shuhong Xiang ◽  
Xiaoqin Nie ◽  
Faqin Dong ◽  
Wencai Cheng ◽  
Mingxue Liu ◽  
...  
Keyword(s):  
Theoretical Calculation ◽  
Interaction Mechanism ◽  
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scholarly journals Insights into the interaction mechanism between tiagabine hydrochloride and two serum albumins

RSC Advances ◽  
2018 ◽  
Vol 8 (44) ◽  
pp. 24953-24960 ◽  
Author(s):  
Weiling Zhuo ◽  
Xilin Peng ◽  
Xiang Lin
Keyword(s):  
Interaction Mechanism ◽  
Serum Albumins

Tiagabine could bind in Sudlow site II of HSA and BSA.

Specific features of penetration and trapping of a magnetic flux in film and bulk YBCO high-temperature superconductors

2018 ◽  
Vol 32 (31) ◽  
pp. 1850346
Author(s):  
Kh. R. Rostami
Keyword(s):  
Magnetic Field ◽  
High Temperature ◽  
Magnetic Flux ◽  
External Field ◽  
High Temperature Superconductors ◽  
Interaction Mechanism ◽  
Differential Method ◽  
Bulk Ybco ◽  
The Magnetic Field ◽  
Insight Into

An oscillatory differential method of local diagnostics of superconductors is applied to the analysis of the trapped magnetic flux and the effective demagnetization factor in YBCO samples. Regular steps over certain intervals of the external field are observed on the magnetic-field dependence of these parameters. It is demonstrated that, as the external field increases, crystallites in a sample are decomposed into sub- and nanocrystallites with a size much less than the penetration depth [Formula: see text] of the magnetic field. The first critical thermodynamic magnetic fields of sub- and nanocrystallites are determined. These results allow one to reveal the interaction mechanism between magnetic and crystalline microstructures of superconductors and provide a deeper insight into the physical processes that occur in high-temperature superconductors (HTSCs) in a magnetic field.

Insight into the Interaction Mechanism of Nicotine, NNK, and NNN with Cytochrome P450 2A13 Based on Molecular Dynamics Simulation

2019 ◽  
Vol 60 (2) ◽  
pp. 766-776 ◽  
Author(s):  
Jorddy Neves Cruz ◽  
Mozaniel Santana de Oliveira ◽  
Sebastião Gomes Silva ◽  
Antonio Pedro da Silva Souza Filho ◽  
Daniel Santiago Pereira ◽  
...  
Keyword(s):  
Molecular Dynamics ◽  
Cytochrome P450 ◽  
Molecular Dynamics Simulation ◽  
Interaction Mechanism ◽  
Dynamics Simulation ◽  
Insight Into
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