Rheological behavior of biodegradable N-succinyl chitosan-g-poly (acrylic acid) hydrogels and their applications as drug carrier and in vitro theophylline release

2018 ◽  
Vol 117 ◽  
pp. 454-466 ◽  
Author(s):  
Shahid Bashir ◽  
Yin Yin Teo ◽  
S. Ramesh ◽  
K. Ramesh ◽  
Muhammad Waheed Mushtaq
2018 ◽  
Vol 21 (1) ◽  
pp. 145-162 ◽  
Author(s):  
Abdulaziz Ali Alghamdi ◽  
Abdulellah Alsolami ◽  
Waseem Sharaf Saeed ◽  
Abdel-Basit Mohammed Al-Odayni ◽  
Abdelhabib Semlali ◽  
...  

2009 ◽  
Vol 24 (5) ◽  
pp. 1653-1661 ◽  
Author(s):  
Qunwei Tang ◽  
Jihuai Wu ◽  
Jianming Lin ◽  
Shijun Fan ◽  
De Hu

A poly(acrylic acid)/gelatin interpenetrating network hydrogel was synthesized by aqueous solution polymerization. The influences of preparation conditions including cross-linker, initiator, gelatin content, and neutralization degree on the swelling ratios of the hydrogels are investigated. The swelling, mechanical strength, biodegradability, and drug-release properties of poly(acrylic acid)/gelatin hydrogel are evaluated. The hydrogel has excellent mechanical properties; tensile strength is 1500 kPa, and elongation at break is 887%, respectively. The in vitro biodegradation shows that an interpenetrating network structure exists in the poly(acrylic acid)/gelatin hybrid hydrogel. A release study indicates that the theophylline release from the hydrogel depends on the cross-linking density of the hydrogel and pH of the medium, and the drug diffusion obeys an anomalous transport model.


2001 ◽  
Vol 218-220 ◽  
pp. 347-352 ◽  
Author(s):  
S. Kenny ◽  
Martin Buggy ◽  
T. Pembroke ◽  
R. Hill ◽  
P.V. Hatton

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