Tissue-sealing and anti-adhesion properties of an in situ hydrogel of hydrophobically-modified Alaska pollock-derived gelatin

The enhancement of both thermal and mechanical properties of epoxy materials using nanomaterials becomes a target in coating of the steel to protect it from aggressive environmental conditions for a long time, with reducing the cost. In this respect, the adhesion properties of the epoxy with the steel surfaces, and its proper superhyrophobicity to repel the seawater humidity, can be optimized via addition of green nanoparticles (NPs). In-situ modification of silver (Ag) and calcium carbonate (CaCO3) NPs with oleic acid (OA) was carried out during the formation of Ag−OA and CaCO3−OA, respectively. The epoxide oleic acid (EOA) was also used as capping for Ca−O3 NPs by in-situ method and epoxidation of Ag−OA NPs, too. The morphology, thermal stability, and the diameters of NPs, as well as their dispersion in organic solvent, were investigated. The effects of the prepared NPs on the exothermic curing of the epoxy resins in the presence of polyamines, flexibility or rigidity of epoxy coatings, wettability, and coatings durability in aggressive seawater environment were studied. The obtained results confirmed that the proper superhyrophobicity, coating adhesion, and thermal stability of the epoxy were improved after exposure to salt spray fog for 2000 h at 36 °C.

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Efficacy and Safety of Azelaic Acid Nanocrystal-Loaded In Situ Hydrogel in the Treatment of Acne Vulgaris

Pharmaceutics ◽

10.3390/pharmaceutics13040567 ◽

2021 ◽

Vol 13 (4) ◽

pp. 567

Author(s):

Ivona Tomić ◽

Sandra Miočić ◽

Ivan Pepić ◽

Dubravka Šimić ◽

Jelena Filipović-Grčić

Keyword(s):

Azelaic Acid ◽

Controlled Trial ◽

Acne Vulgaris ◽

Topical Therapy ◽

Adverse Event Rate ◽

Double Blind ◽

Inflammatory Lesions ◽

First Choice ◽

In Situ Hydrogel

Acne vulgaris is a common, multifactorial, inflammatory skin disease affecting the pilosebaceous unit. Topical therapy is the first choice in the treatment of mild to moderate acne, and azelaic acid (AZA) is one of the most commonly used drugs. The aim of this study was to evaluate the safety and efficacy of a low-dose azelaic acid nanocrystal (AZA-NC) hydrogel in the treatment of mild to moderate facial acne. The study was designed as a double-blind, randomized controlled trial. Patients were randomized to treatment with AZA-NC hydrogel, 10%, or AZA cream, 20%, administered in quantities of approximately 1 g twice daily for 8 weeks. Efficacy of therapy was measured by the number of lesions and safety by the frequency and severity of adverse events. At week 8, the success rate of treatment with AZA-NC hydrogel, 10%, was 36.51% (p < 0.001) versus 30.37% (p < 0.001) with AZA cream. At week 8, treatment with AZA-NC hydrogel, 10%, resulted in a significant reduction in total inflammatory lesions from baseline of 39.15% (p < 0.001) versus 33.76% (p < 0.001) with AZA cream, and a reduction in non-inflammatory lesions from baseline of 34.58% (p < 0.001) versus 27.96% (p < 0.001) with AZA cream, respectively. The adverse event rate was low and mostly mild.

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Novel environment friendly olive pomace-cyclohexanone formaldehyde composite resin

Pigment & Resin Technology ◽

10.1108/prt-02-2021-0018 ◽

2021 ◽

Vol ahead-of-print (ahead-of-print) ◽

Author(s):

Selda Sert ◽

Nilgün Kızılcan

Keyword(s):

Organic Solvents ◽

Condensation Reaction ◽

Agricultural Waste ◽

Composite Resins ◽

Formaldehyde Resin ◽

Olive Pomace ◽

Adhesion Properties ◽

Content Type ◽

Naoh Solution

Purpose Cyclohexanone-formaldehyde resin (CFR) was in situ modified with olive pomace (OP) in the presence of sodium hydroxide. The purpose of this study is to produce eco-friendly OP modified cyclohexanone composite resins (OPCFCR) with a one-step method that has higher condensation reaction temperature than CFR. The water absorption properties, gloss value and cross-cut adhesion properties of the product were investigated. Design/methodology/approach Cyclohexanone, formalin (37% aqueous solution) and tannin were mixed and 20% aqueous NaOH solution was added to produce the resin. OP has environmentally friendly bio-based lignin, cellulose and phenolic compounds and the OP structure has been incorporated into the structure of the CFR resin during the in situ modification, such as resole resin and polysaccharide. The weights of pomace were used as 5% and 10% of the weight of cyclohexanone in cyclohexanone-formaldehyde composite resins, respectively. Findings There is an improvement in the properties of the OPCFCR produced from an agricultural waste that is very abundant in Gulf of Edremit region of Balikesir. The OPCFCRs were soluble in common organic solvents. The product OPCFCR has a dark red-brown color. Research limitations/implications The reaction mixture must be stirred continuously. Subsequently, 37% formalin was added dropwise in total while refluxing. The amount of aqueous NaOH solution is limited as the formed resin may become insoluble in common organic solvents. At the end of the reaction, a water-insoluble resin is obtained. Practical implications This study provides the application of ketonic resins. The OPCFCR containing phenolic groups may also promote the adhesive strength of a coating. Social implications These resins may be used for the preparation of adhesive. OP, with a large amount of catechol groups, was considered for reducing the formaldehyde emission level on the adhesive system. Originality/value OPCFCR has been synthesized in the presence of a base catalyst. Environmental and ecological concerns have increased the attention paid by chemical industry to renewable raw materials.

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Thermosensitive in situ hydrogel based on the hybrid of hyaluronic acid and modified PCL/PEG triblock copolymer

Carbohydrate Polymers ◽

10.1016/j.carbpol.2014.03.016 ◽

2014 ◽

Vol 108 ◽

pp. 26-33 ◽

Cited By ~ 19

Author(s):

Zesheng Lv ◽

Longlong Chang ◽

Xingwen Long ◽

Jianping Liu ◽

Yuzhang Xiang ◽

...

Keyword(s):

Hyaluronic Acid ◽

Triblock Copolymer ◽

In Situ Hydrogel

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Chapter 8. From Bench to Bedside – OncoGel™, an In Situ Hydrogel for In Vivo Applications

Biomaterials Science Series - Biodegradable Thermogels ◽

10.1039/9781788012676-00133 ◽

2018 ◽

pp. 133-144

Author(s):

Ankshita Prasad ◽

David James Young ◽

Xian Jun Loh

Keyword(s):

In Situ Hydrogel

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The interaction between self – assembling peptides and emodin and the controlled release of emodin from in-situ hydrogel

Artificial Cells Nanomedicine and Biotechnology ◽

10.1080/21691401.2019.1673768 ◽

2019 ◽

Vol 47 (1) ◽

pp. 3961-3975 ◽

Cited By ~ 3

Author(s):

Weipeng Wei ◽

Cui Meng ◽

Yuhe Wang ◽

Yongsheng Huang ◽

Wenbin Du ◽

...

Keyword(s):

Controlled Release ◽

Self Assembling ◽

In Situ Hydrogel

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Fabrication of Injectable, Porous Hyaluronic Acid Hydrogel Based on an In-Situ Bubble-Forming Hydrogel Entrapment Process

Polymers ◽

10.3390/polym12051138 ◽

2020 ◽

Vol 12 (5) ◽

pp. 1138

Author(s):

Lixuan Wang ◽

Shiyan Dong ◽

Yutong Liu ◽

Yifan Ma ◽

Jingjing Zhang ◽

...

Keyword(s):

Hyaluronic Acid ◽

Regenerative Medicine ◽

In Vivo Studies ◽

Injectable Hydrogels ◽

Cell Behaviors ◽

Porous Architecture ◽

In Situ Hydrogel

Injectable hydrogels have been widely applied in the field of regenerative medicine. However, current techniques for injectable hydrogels are facing a challenge when trying to generate a biomimetic, porous architecture that is well-acknowledged to facilitate cell behaviors. In this study, an injectable, interconnected, porous hyaluronic acid (HA) hydrogel based on an in-situ bubble self-generation and entrapment process was developed. Through an amide reaction between HA and cystamine dihydrochloride activated by EDC/NHS, CO2 bubbles were generated and were subsequently entrapped inside the substrate due to a rapid gelation-induced retention effect. HA hydrogels with different molecular weights and concentrations were prepared and the effects of the hydrogel precursor solution’s concentration and viscosity on the properties of hydrogels were investigated. The results showed that HA10-10 (10 wt.%, MW 100,000 Da) and HA20-2.5 (2.5 wt.%, MW 200,000 Da) exhibited desirable gelation and obvious porous structure. Moreover, HA10-10 represented a high elastic modulus (32 kPa). According to the further in vitro and in vivo studies, all the hydrogels prepared in this study show favorable biocompatibility for desirable cell behaviors and mild host response. Overall, such an in-situ hydrogel with a self-forming bubble and entrapment strategy is believed to provide a robust and versatile platform to engineer injectable hydrogels for a variety of applications in tissue engineering, regenerative medicine, and personalized therapeutics.

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