Inflammatory markers and plaque morphology: An optical coherence tomography study

2012 ◽  
Vol 154 (3) ◽  
pp. 287-292 ◽  
Author(s):  
Konstantina P. Bouki ◽  
Mihail G. Katsafados ◽  
Dionissios N. Chatzopoulos ◽  
Stavroula N. Psychari ◽  
Konstantinos P. Toutouzas ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Inflammatory Markers ◽  
Plaque Morphology ◽  
Optical Coherence

Preoperative assessment of computerized tomography angiography to predict success for crossing long Trans-Atlantic Inter-Society Consensus D lesions using the optical coherence tomography catheter

Vascular ◽  
2017 ◽  
Vol 26 (4) ◽  
pp. 362-367 ◽  
Author(s):  
Ryan J Kim ◽  
Jamie B Smith ◽  
Todd R Vogel
Keyword(s):  
Optical Coherence Tomography ◽  
Lower Extremity ◽  
Computerized Tomography ◽  
Femoral Artery ◽  
Superficial Femoral Artery ◽  
Plaque Morphology ◽  
Optical Coherence ◽  
Total Occlusion ◽  
Chronic Total Occlusions ◽  
Computerized Tomography Angiography

Objectives Optical coherence tomography chronic total occlusion catheter, the Ocelot (Avinger Inc., Redwood City, CA), has been utilized to cross Trans-Atlantic Inter-Society Consensus D lesions. This study evaluated the preoperative computerized tomography angiography of chronic total occlusions in the superficial femoral artery to predict clinical success. Methods We reviewed all patients who underwent lower extremity procedures with the Ocelot catheter from June 2014 to August 2016. Patients who had a preoperative computerized tomography angiography were evaluated. Final outcomes, plaque morphology, lesion length, calcium surface area, lesion location, and patient characteristics were analyzed. Results A total of 107 patients underwent lower extremity interventions with the Ocelot catheter. Seventy patients had a preoperative computerized tomography angiography scan prior to lower extremity intervention and 77% (54) had Trans-Atlantic Inter-Society Consensus D lesions that were crossed. Mean age was 62.8 years and 68.6% were male. Mean chronic total occlusion length was 182.7 mm (170.8 mm crossed vs. 222.6 mm uncrossed, p = 0.03). Calcium distribution differed significantly ( p<.01): circumferential (14.8 vs. 12.5%); eccentric (85 vs. 62.5%); and complete calcium occlusion (0 vs. 25%) for lesions that were crossed and uncrossed, respectively. Significant differences ( p<.0001) were found when calcium occlusion was less than 50% (87 vs. 31%), 51–75% (9.3 vs. 31.2%), and 76–100% (3.7 vs. 37.5%). Total calcium length in crossed lesion was 51.6 mm, and 92.8 mm in uncrossed lesions ( p = 0.10). No significant differences were noted for patient gender, occlusion location (proximal, middle, and distal superficial femoral artery), and kidney function. Conclusion The Ocelot catheter is an effective method to cross long Trans-Atlantic Inter-Society Consensus D lesions. Superficial femoral artery lesions longer than 17 cm and focal plaque morphology, specifically a total cross-sectional area of calcium and a calcium surface area greater than 50% were most predictive of failure to cross Trans-Atlantic Inter-Society Consensus D superficial femoral artery lesions. Computerized tomography angiography is an effective tool to predict success for crossing chronic total occlusions using optical coherence tomography technology and a critical consideration for patient selection.

scholarly journals Identification of Symptomatic Carotid Artery Plaque: A Three-Item Scale Combined Angiography With Optical Coherence Tomography

2021 ◽  
Vol 15 ◽  
Author(s):  
Qingwen Yang ◽  
Hongquan Guo ◽  
Xuan Shi ◽  
Xiaohui Xu ◽  
Mingming Zha ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Carotid Plaque ◽  
Large Scale ◽  
Plaque Morphology ◽  
Optical Coherence ◽  
Carotid Artery Plaque ◽  
Carotid Plaques ◽  
Symptomatic Carotid ◽  
Oct Imaging ◽  
Item Scale

Introduction: Symptomatic carotid disease conveys a high risk of recurrent stroke. Plaque morphology and specific plaque characteristics are associated with the risk of stroke. This study aimed to evaluate the detailed plaque features by optical coherence tomography (OCT) and develop a simple scale combining clinical indicators, digital subtraction angiography (DSA), and OCT imaging markers to identify symptomatic carotid plaque.Methods: Carotid plaques from consecutive patients who underwent carotid OCT imaging between June 2017 and June 2021 were evaluated. Clinical characteristics, DSA, and OCT data were compared between the symptomatic and asymptomatic groups. Logistic regression was performed to identify the factors associated with symptomatic carotid plaque and to develop a scale. The area under the receiver operating characteristic curve (AUC) was used to evaluate the performance of the scale.Results: A total of 90 carotid plaques from 90 patients were included (symptomatic 35.6%, asymptomatic 64.4%). Three main factors were found to be associated with symptomatic carotid plaque: high-density lipoprotein cholesterol (HDL-C) &lt;0.925 mmol/L (OR, 4.708; 95% CI, 1.640 to 13.517; P = 0.004), irregular plaque (OR, 4.017; 95% CI, 1.250 to 12.910; P = 0.020), and white thrombus (OR, 4.594; 95% CI, 1.141 to 18.487; P = 0.032). The corresponding score of three items produced a scale with good discrimination (AUC, 0.768; 95% CI, 0.665 to 0.871). The optimal cutoff value of the scale was 1.5 points with 59.4% sensitivity and 84.5% specificity.Conclusion: The three-item scale comprising HDL-C &lt;0.925 mmol/L, angiographical irregular plaque, and white thrombus detected by OCT may provide information to identify symptomatic carotid plaque. Further large-scale studies are required to validate whether the symptomatic carotid plaque scale is clinically valuable in recognizing carotid atherosclerosis in the early stages.

100Culprit plaque morphology in patients with and without preinfarction angina: an optical coherence tomography imaging study

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
R Vergallo ◽  
I Porto ◽  
A Ricchiuto ◽  
A Buonpane ◽  
F Coletti ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Chest Pain ◽  
Plaque Rupture ◽  
Imaging Study ◽  
Coronary Intervention ◽  
Plaque Morphology ◽  
Optical Coherence ◽  
Thrombolytic Activity ◽  
Oct Imaging ◽  
Macrophage Accumulation

Abstract Background The relation between culprit plaque morphology and the clinical presentation of an acute myocardial infarction (AMI) has not been examined in detail. Purpose To study the culprit plaque morphology in patients with AMI with or without preinfarction angina using optical coherence tomography (OCT) imaging. Methods A total of 102 patients with AMI (32 STEMI, 70 NSTEMI) who underwent OCT imaging before percutaneous coronary intervention were enrolled. Patients were classified as: i) having either intermittent chest pain in the six hours preceding the final episode of pain, or unstable angina (or both) in the week preceding AMI (preinfarction angina group); or ii) having a single episode of chest pain without unstable symptoms in the preceding week (no preinfarction angina group). Culprit plaque was classified as plaque rupture (PR) or intact fibrous cap (IFC), as previously described. Prati thrombus score was calculated, and the prevalence of calcification, neovascularization, and OCT-defined macrophage accumulation was assessed. Results Patients with preinfarction angina showed a significantly higher prevalence of IFC than PR, while those without preinfarction angina showed a significantly higher prevalence of PR than IFC (Figure). PR in patients with preinfarction angina were more frequently associated with macrophage accumulation, while those in patients without preinfarction angina were not (Figure). White thrombus tended to be more frequent in patients with preinfarction angina than in those without (85.7% vs. 63.6%, p=0.097), and Prati thrombus score tended to be lower [22.0 (15.8–30.3) vs. 38.5 (12.8–67.5), p=0.145]. Calcifications were significantly less frequent in patients with preinfarction angina than in those without (22.0% vs. 40.4%, p=0.045), while neovascularization tended to be more frequent (58.0% vs. 42.3%, p=0.113). Conclusions Patients with preinfarction angina have a distinct culprit plaque phenotype, frequently characterized by IFC and a relatively lower thrombotic burden, probably reflecting a prevalence of reparative mechanisms and spontaneous thrombolytic activity in these patients.

Culprit plaque morphology in STEMI – an optical coherence tomography study: insights from the TOTAL-OCT substudy

2016 ◽  
Vol 12 (6) ◽  
pp. 716-723 ◽  
Author(s):  
Olli A. Kajander ◽  
Natalia Pinilla-Echeverri ◽  
Sanjit S. Jolly ◽  
Ravinay Bhindi ◽  
Heini Huhtala ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Plaque Morphology ◽  
Optical Coherence
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