Biological versus mechanical heart valve prosthesis during pregnancy in women with congenital heart disease

2018 ◽  
Vol 268 ◽  
pp. 106-112 ◽  
Author(s):  
Heleen Lameijer ◽  
Ymkje J. van Slooten ◽  
Monique R.M. Jongbloed ◽  
Martijn A. Oudijk ◽  
Marlies A.M. Kampman ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Heart Valve ◽  
Congenital Heart ◽  
Mechanical Heart Valve ◽  
Heart Valve Prosthesis ◽  
Valve Prosthesis

scholarly journals Successful Treatment of Acute Lymphoblastic Leukemia in a Child with Trisomy 21 and Complex Congenital Heart Disease with Mechanical Prosthetic Valve

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Saima Alvi ◽  
Evan Shereck ◽  
Manraj K. S. Heran ◽  
George G. S. Sandor ◽  
Shahrad Rod Rassekh
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Acute Lymphoblastic Leukemia ◽  
Heart Valve ◽  
Trisomy 21 ◽  
Congenital Heart ◽  
Lymphoblastic Leukemia ◽  
Mechanical Heart Valve ◽  
Prosthetic Heart Valve ◽  
Complex Congenital Heart Disease

A 10-year-old girl with trisomy 21 and complex congenital heart disease presented with acute lymphoblastic leukemia. Her chemotherapy required modifications due to poor baseline cardiac status and a mechanical prosthetic heart valve that was dependent on anticoagulation. We describe our management including the use of low-molecular-weight heparin as anticoagulation for a mechanical heart valve, the safe delivery of intrathecal chemotherapy included bridging with unfractionated heparin, and the use of fluoroscopic guidance to minimize the risk of bleeding. Adjustments were made to avoid anthracyclines. The child tolerated therapy well without complications and remains relapse free five years after diagnosis.

Static and Dynamic Stresses during Valve Closure of a Bileaflet Mechanical Heart Valve Prosthesis

1991 ◽  
Vol 14 (12) ◽  
pp. 781-788 ◽  
Author(s):  
T.H. Chiang ◽  
H. Lam ◽  
R. Quijano ◽  
R. Donham ◽  
P. Gilliam ◽  
...  
Keyword(s):  
Heart Valve ◽  
Mechanical Heart Valve ◽  
Heart Valve Prosthesis ◽  
Valve Prosthesis ◽  
Valve Closure ◽  
Element Analysis ◽  
Dynamic Stresses ◽  
Magnitude Distribution ◽  
Bileaflet Mechanical Heart Valve ◽  
The Impact

The effect of contact geometry and component compliance on the magnitude, distribution, and state of various types of stresses on a bileaflet mechanical heart valve prosthesis during valve closure was analyzed using an Edwards-Duromedics™ mitral valve as example. Static and dynamic stresses developing on both the leaflet and pivot ball during valve closure were modeled using finite element analysis (FEA). Uniform contact between the leaflet and housing as well as between the pivot ball and pivot slot can significantly reduce both static and dynamic stresses around the contact area. The level of the dynamic flexural stresses can be an order of magnitude higher than that of the static stresses. When both the radial and axial compliance of the housing are taken into consideration, peak dynamic stress was more than 40% less than that generated through the impact between a moving leaflet and a non-compliant rigid housing.

Home heparin therapy used in a pregnant patient with a mechanical heart valve prosthesis

1994 ◽  
Vol 58 (4) ◽  
pp. 1168-1170 ◽  
Author(s):  
Victor A. Ferraris ◽  
Robert R. Klingman ◽  
Linda Dunn ◽  
Steven Fein ◽  
Marla Eglowstein ◽  
...  
Keyword(s):  
Heart Valve ◽  
Mechanical Heart Valve ◽  
Pregnant Patient ◽  
Heparin Therapy ◽  
Heart Valve Prosthesis ◽  
Valve Prosthesis
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