Risk of de-novo heart failure and competing risk in asymptomatic patients with structural heart diseases

2020 ◽  
Vol 307 ◽  
pp. 87-93 ◽  
Author(s):  
Tsuyoshi Takada ◽  
Yasuhiko Sakata ◽  
Kotaro Nochioka ◽  
Masanobu Miura ◽  
Ruri Abe ◽  
...  
Keyword(s):  
Heart Failure ◽  
De Novo ◽  
Heart Diseases ◽  
Competing Risk ◽  
Asymptomatic Patients ◽  
Structural Heart Diseases

Genetics of sudden cardiac death in children and young athletes

2012 ◽  
Vol 23 (2) ◽  
pp. 159-173 ◽  
Author(s):  
Georgia Sarquella-Brugada ◽  
Oscar Campuzano ◽  
Anna Iglesias ◽  
Josep Sánchez-Malagón ◽  
Myriam Guerra-Balic ◽  
...  
Keyword(s):  
Sudden Cardiac Death ◽  
Cardiac Death ◽  
Heart Diseases ◽  
Preventive Treatment ◽  
Incomplete Penetrance ◽  
Variable Expression ◽  
Asymptomatic Patients ◽  
Common Causes ◽  
Structural Heart Diseases ◽  
Diagnostic Work

AbstractSudden cardiac death is a rare but socially devastating event. The most common causes of sudden cardiac death are congenital electrical disorders and structural heart diseases. The majority of these diseases have an incomplete penetrance and variable expression; therefore, patients may be unaware of their illness. In several cases, physical activity can be the trigger for sudden cardiac death as first symptom. Our purpose is to review the causes of sudden cardiac death in sportive children and young adults and its genetic background. Symptomatic individuals often receive an implantable cardioverter-defibrillator, the preventive treatment for sudden cardiac death in most of cases due to channelopathies, which can become a challenging option in young and active patients. The identification of one of these diseases in asymptomatic patients has similarly a great impact on their everyday life, especially on their ability to undertake competitive physical activities, and the requirement of prophylactic treatment. We review main causes of sudden cardiac death in relation to its genetics and diagnostic work-up.

scholarly journals Characteristics and management of acute heart failure patients in a single university hospital center

Medicina ◽  
2009 ◽  
Vol 45 (11) ◽  
pp. 855 ◽  
Author(s):  
Laura Venskutonytė ◽  
Irena Molytė ◽  
Rūta Ablonskytė-Dūdonienė ◽  
Vaida Mizarienė ◽  
Aušra Kavoliūnienė
Keyword(s):  
Heart Failure ◽  
Acute Heart Failure ◽  
De Novo ◽  
Systolic Function ◽  
Heart Diseases ◽  
Left Ventricular ◽  
University Hospital ◽  
Left Ventricular Ejection ◽  
Ventricular Ejection Fraction ◽  
Hospital Center

Objective. To evaluate the causes of acute heart failure, complications, management, and outcomes.Material and methods. A total of 200 patients with diagnosed de novo acute heart failure (27.5%) or worsening chronic heart failure (72.5%) were treated at the Department of Cardiology, Hospital of Kaunas University of Medicine, which was participating in the Euro Heart Failure Survey-II (EHFS-II). The patients were divided into five groups: 1) chronic decompensated heart failure (66.0%); 2) pulmonary edema (13.0%); 3) hypertensive heart failure (7.5%); 4) cardiogenic shock (11.0%); and 5) right heart failure (2.5%). Results. Hypertensive and coronary heart diseases were the most common underlying conditions of acute heart failure. Noncompliance with the prescribed medications was present as the most frequent precipitating factor in more than half of the cases. Left ventricular ejection fraction of >45% was found in 28.64% of cases. Intravenous diuretics (74.5%), nitrates (44.0%), and heparin (71.0%) were the most widely used in the acute phase. At discharge from hospital, 96.69% of patients were given diuretics; 80.11%, angiotensin-converting enzyme inhibitors; and 62.43%, beta-blockers. The mean duration of inhospital stay was 13 days; death rate was 9.5%: after 3 months and 12 months, it was 7.5% and 11.5%, respectively. Conclusion. Preserved systolic function, multiple concomitant diseases, and high mortality rates were observed in a substantial proportion of the patients hospitalized due to acute heart failure. The management of the patients in a university hospital center was performed in accordance with the international guidelines.

Etiology and Predictive Factors of De Novo Heart Failure in Stage-B Asymptomatic Patients -Insight from the CHART-2 Study-

2012 ◽  
Vol 18 (10) ◽  
pp. S149
Author(s):  
Tsuyoshi Takada ◽  
Yasuhiko Sakata ◽  
Satoshi Miyata ◽  
Jun Takahashi ◽  
Kotaro Nochioka ◽  
...  
Keyword(s):  
Heart Failure ◽  
Predictive Factors ◽  
De Novo ◽  
Asymptomatic Patients

Potential Role of Inflammation in Associations between Particulate Matter and Heart Failure

2018 ◽  
Vol 24 (3) ◽  
pp. 341-358 ◽  
Author(s):  
Xiaotong Ji ◽  
Yingying Zhang ◽  
Guangke Li ◽  
Nan Sang
Keyword(s):  
Heart Failure ◽  
Particulate Matter ◽  
Inflammatory Response ◽  
Heart Diseases ◽  
Experimental Studies ◽  
Epidemiological Studies ◽  
Inflammatory Mechanism ◽  
High Concentrations ◽  
Future Work ◽  
The Relationship

Recently, numerous studies have found that particulate matter (PM) exposure is correlated with increased hospitalization and mortality from heart failure (HF). In addition to problems with circulation, HF patients often display high expression of cytokines in the failing heart. Thus, as a recurring heart problem, HF is thought to be a disorder characterized in part by the inflammatory response. In this review, we intend to discuss the relationship between PM exposure and HF that is based on inflammatory mechanism and to provide a comprehensive, updated evaluation of the related studies. Epidemiological studies on PM-induced heart diseases are focused on high concentrations of PM, high pollutant load exposure in winter, or susceptible groups with heart diseases, etc. Furthermore, it appears that the relationship between fine or ultrafine PM and HF is stronger than that between HF and coarse PM. However, fewer studies paid attention to PM components. As for experimental studies, it is worth noting that coarse PM may indirectly promote the inflammatory response in the heart through systematic circulation of cytokines produced primarily in the lungs, while ultrafine PM and its components can enter circulation and further induce inflammation directly in the heart. In terms of PM exposure and enhanced inflammation during the pathogenesis of HF, this article reviews the following mechanisms: hemodynamics, oxidative stress, Toll-like receptors (TLRs) and epigenetic regulation. However, many problems are still unsolved, and future work will be needed to clarify the complex biologic mechanisms and to identify the specific components of PM responsible for adverse effects on heart health.

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