scholarly journals Chronic nicotine alters cannabinoid‐mediated locomotor activity and receptor density in periadolescent but not adult male rats

2009 ◽  
Vol 27 (3) ◽  
pp. 263-269 ◽  
Author(s):  
Linda L. Werling ◽  
Stephanie Collins Reed ◽  
Dean Wade ◽  
Sari Izenwasser
Small ◽  
2013 ◽  
Vol 9 (9-10) ◽  
pp. 1715-1720 ◽  
Author(s):  
Yongbin Zhang ◽  
Sherry A. Ferguson ◽  
Fumiya Watanabe ◽  
Yvonne Jones ◽  
Yang Xu ◽  
...  

2008 ◽  
Vol 66 (4) ◽  
pp. 844-847 ◽  
Author(s):  
Valdenilson Ribeiro Ribas ◽  
Helena Karine Rufino Aniceto ◽  
Hugo André de Lima Martins ◽  
Ketlin Helenise dos Santos Ribas ◽  
Renata de Melo Guerra-Ribas ◽  
...  

The objective of this study was evaluate the anxiety and locomotor activity (LA) in 52 Wistar adult male rats, being 26 treated with fluoxetine (10 mg/Kg - sc) in the neonatal period. These same rats received foot shock (FS) (1.6-mA - 2-s) in the 90th day. The anxiety and LA were appraised by plus-maze. The time spent in the open arms was used as anxiety index and the LA was measured by number of entries in closed arms (NECA) and the total of entries (TE). T-test was used with p<0.05 and expresses data in mean±SEM. There were reductions with the fluoxetine group in the NECA (2.35±0.33) and in the TE (3.96±0.61) compared to the controls (4.65±0.52) and (6.96±0.94). The neonatal administration of fluoxetine did not alter the anxiety, but reduced the LA in the animals that received FS.


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