scholarly journals Identification of potential novel hosts and the risk of infection with lymphocytic choriomeningitis virus in humans in Gabon, Central Africa

2021 ◽  
Vol 105 ◽  
pp. 452-459
Author(s):  
Yuri Ushijima ◽  
Haruka Abe ◽  
Takehiro Ozeki ◽  
Georgelin N. Ondo ◽  
Marien J.V.M. Mbadinga ◽  
...  
Keyword(s):  
Central Africa ◽  
Lymphocytic Choriomeningitis ◽  
Lymphocytic Choriomeningitis Virus ◽  
Risk Of Infection

scholarly journals Evidence of Lymphocytic Choriomeningitis Virus (LCMV) in Domestic Mice in Gabon: Risk of Emergence of LCMV Encephalitis in Central Africa

2014 ◽  
Vol 89 (2) ◽  
pp. 1456-1460 ◽  
Author(s):  
Nadine N′Dilimabaka ◽  
Nicolas Berthet ◽  
Virginie Rougeron ◽  
Joa Braïthe Mangombi ◽  
Patrick Durand ◽  
...  
Keyword(s):  
Public Health ◽  
Phylogenetic Analyses ◽  
Central Africa ◽  
Lymphocytic Choriomeningitis ◽  
Lymphocytic Choriomeningitis Virus ◽  
Fatal Disease ◽  
Content Type ◽  
Virus Dissemination ◽  
Acute Encephalitis ◽  
Close Relationship

Lymphocytic choriomeningitis virus (LCMV) can cause acute fatal disease on all continents but was never detected in Africa. We report the first detection of LCMV RNA in a common European house mouse (Mus musculusdomesticus) in Africa. Phylogenetic analyses show a close relationship with North American strains. These findings suggest that there is a risk of the appearance of LCMV acute encephalitis cases. This is a perfect example of virus dissemination by its natural host that may have dramatic public health consequences.

Age Distribution of Lymphocytic Choriomeningitis Virus Serum Antibody in Birmingham, Alabama: Evidence of a Decreased Risk of Infection

1997 ◽  
Vol 57 (1) ◽  
pp. 37-41 ◽  
Author(s):  
Jong Y. Park ◽  
Pierre E. Rollin ◽  
H. Michael Maetz ◽  
Charles B. Stephensen ◽  
Ken B. Waites ◽  
...  
Keyword(s):  
Serum Antibody ◽  
Age Distribution ◽  
Lymphocytic Choriomeningitis ◽  
Lymphocytic Choriomeningitis Virus ◽  
Risk Of Infection

Antiviral Effect of Interferon Lambda Against Lymphocytic Choriomeningitis Virus

2015 ◽  
Vol 35 (7) ◽  
pp. 540-553 ◽  
Author(s):  
Lubomira Lukacikova ◽  
Ingrid Oveckova ◽  
Tatiana Betakova ◽  
Katarina Laposova ◽  
Katarina Polcicova ◽  
...  
Keyword(s):  
Antiviral Effect ◽  
Lymphocytic Choriomeningitis ◽  
Lymphocytic Choriomeningitis Virus ◽  
Interferon Lambda

scholarly journals The Nucleoprotein Is Required for Lymphocytic Choriomeningitis Virus-Based Vaccine Vector Immunogenicity

2015 ◽  
Vol 89 (22) ◽  
pp. 11734-11738 ◽  
Author(s):  
Stephanie Darbre ◽  
Susan Johnson ◽  
Sandra Kallert ◽  
Paul-Henri Lambert ◽  
Claire-Anne Siegrist ◽  
...  
Keyword(s):  
Gene Expression ◽  
T Cell ◽  
T Cell Responses ◽  
Lymphocytic Choriomeningitis ◽  
Lymphocytic Choriomeningitis Virus ◽  
Viral Transcription ◽  
Genome Replication ◽  
Recombinant Glycoprotein ◽  
Cell Responses ◽  
Deficient Vector

Recombinant glycoprotein-deficient lymphocytic choriomeningitis virus-based vaccine vectors (rLCMV/ΔGP) are potent CD8+T cell inducers. To investigate the underlying molecular requirements, we generated a nucleoprotein-deficient vector counterpart (rLCMV/ΔNP). NP but not GP is a minimaltrans-acting factor for viral transcription and genome replication. We found that, unlike rLCMV/ΔGP, rLCMV/ΔNP failed to elicit detectable CD8+T cell responses unless NP wastranscomplemented in a transgenic host. Hence, NP-dependent intracellular gene expression is essential for LCMV vector immunogenicity.

Stage of primary infection with lymphocytic choriomeningitis virus determines predisposition or resistance of mice to secondary bacterial infections

2006 ◽  
Vol 196 (2) ◽  
pp. 79-88 ◽  
Author(s):  
Marina Gumenscheimer ◽  
Sandra Balkow ◽  
Markus M. Simon ◽  
Emilio Jirillo ◽  
Chris Galanos ◽  
...  
Keyword(s):  
Primary Infection ◽  
Bacterial Infections ◽  
Lymphocytic Choriomeningitis ◽  
Lymphocytic Choriomeningitis Virus
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