scholarly journals Handgrip exercise elevates basilic venous hemodynamic parameters in healthy subjects

2014 ◽  
Vol 1 (4) ◽  
pp. 389-393
Author(s):  
Min Zhang ◽  
Xiu-Xin Fang ◽  
Ming-E. Li ◽  
Chun-Hui Zheng ◽  
Xi-Huan Zhou ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Hemodynamic Parameters ◽  
Handgrip Exercise

scholarly journals Pulse Pressure Variation Can Predict the Hemodynamic Response to Pneumoperitoneum in Dogs: A Retrospective Study

2019 ◽  
Vol 6 (1) ◽  
pp. 17
Author(s):  
Caterina Di Bella ◽  
Luca Lacitignola ◽  
Laura Fracassi ◽  
Despoina Skouropoulou ◽  
Antonio Crovace ◽  
...  
Keyword(s):  
Pulse Pressure ◽  
Roc Curve ◽  
Pulse Pressure Variation ◽  
Healthy Subjects ◽  
Hemodynamic Response ◽  
Hemodynamic Parameter ◽  
Pressure Variation ◽  
Hemodynamic Parameters ◽  
Group Data ◽  
Valid Predictor

Pneumoperitoneum may induce important hemodynamic alterations in healthy subjects. Pulse pressure variation (PPV) is a hemodynamic parameter able to discriminate preload dependent subjects. Anesthesia records of dogs undergoing laparoscopy were retrospectively evaluated. The anesthetic protocol included acepromazine, methadone, propofol and isoflurane administered with oxygen under mechanical ventilation. The hemodynamic parameters were considered five minutes before (BASE) and ten minutes after (P10) the pneumoperitoneum. Based on the cardiac index (CI) variation, at P10, dogs were classified as sensitive (S group, CI ≤ 15%) and non-sensitive (NO-S group). Data were analyzed with the ANOVA test and the ROC curve (p < 0.05). Fifty-five percent of dogs (S) had a reduction of CI ≥ 15% at P10 (2.97 ± 1.4 L/min/m2) compared to BASE (4.32 ± 1.62 L/min/m2) and at P10 in the NO-S group (4.51 ± 1.41 L/min/m2). PPV at BASE was significantly higher in the S group (22.4% ± 6.1%) compared to the NO-S group (10.9% ± 3.3%). The ROC curve showed a threshold of PPV > 16% to distinguish the S and NO-S groups. PPV may be a valid predictor of the hemodynamic response to pneumoperitoneum in dogs. A PPV > 16% can identify patients that may require fluid administration before the creation of pneumoperitoneum.

scholarly journals U-shaped relationship between serum uric acid levels and intrarenal hemodynamic parameters in healthy subjects

2017 ◽  
Vol 312 (6) ◽  
pp. F992-F997 ◽  
Author(s):  
Hideki Uedono ◽  
Akihiro Tsuda ◽  
Eiji Ishimura ◽  
Shinya Nakatani ◽  
Masafumi Kurajoh ◽  
...  
Keyword(s):  
Uric Acid ◽  
Regression Analysis ◽  
Serum Uric Acid ◽  
Healthy Subjects ◽  
Hemodynamic Parameters ◽  
Quadratic Regression ◽  
Dummy Variables ◽  
Arteriolar Resistance ◽  
Glomerular Hemodynamics ◽  
The Relationship

Hyperuricemia has been reported to affect renal hemodynamics. In a recent study, both low and high levels of serum uric acid (SUA) were found to be associated with loss of kidney function. The goal of this study was to evaluate the relationship between SUA levels and intrarenal hemodynamic parameters in healthy subjects, using plasma clearance of para-aminohippurate (CPAH) and inulin (Cin). Renal and glomerular hemodynamics were evaluated by simultaneous measurements of CPAH and Cin in 48 healthy subjects (54.6 ± 13.4 yr). Intrarenal hemodynamic parameters, including efferent and afferent (Ra) arteriolar resistance, were calculated using Gómez’s formulas. Relationships of SUA levels with these intrarenal hemodynamic parameters were examined. In quadratic regression analysis, SUA levels had a significant inverse U-shaped relationship with Cin ( P < 0.0001, R2 = 0.350) and CPAH ( P = 0.0093, R2 = 0.188) and a U-shaped relationship with Ra ( P = 0.0011, R2 = 0.262). In multiple regression analysis with normal (3.5–6.0 mg/dl) and mildly low or high (<3.5 or >6.0 mg/dl) SUA levels entered as dummy variables of zero and one, respectively, mildly low or high SUA levels were significantly and independently associated with Ra (β = 0.230, P = 0.0403) after adjustment for several factors ( R2 = 0.597, P < 0.0001). Both mild hyperuricemia and mild hypouricemia are significantly associated with increased Ra, although weakly. The increase in Ra in subjects with mild hyperuricemia or hypouricemia may be related to renal hemodynamic abnormalities, possibly leading to a decline in renal function.

scholarly journals Platelet ADP-Hypersensitivity by Aging and Isometric Exercise in Diabetics and its Prevention by EG-626

1977 ◽  
Author(s):  
T. Sano ◽  
T. Motomiya ◽  
Y. Itoh ◽  
N. Mashimo ◽  
H. Yamazaki ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Isometric Exercise ◽  
Voluntary Contraction ◽  
Handgrip Exercise ◽  
Isometric Handgrip ◽  
Camp Phosphodiesterase ◽  
Minimum Effective Concentration ◽  
Isometric Handgrip Exercise ◽  
Thrombotic Tendency

The important role of platelet aggregation in the pathophysiology of diabetic vascular disease has been emphasized. The authors devised a new method to assess platelet sensitivity to aggregation performed without centrifugation (Sano et al. Thrombos. Haemostasis April '77 issue, in press). Using this technique, platelet aggregability in diabetics was assessed concerning to age and to. the effect of isometric exercise. The effect of EG-626, a potent cAMP phosphodiesterase inhibiting and thromboxane A2-antagonistic substance, administered prior to exercise was also observed.In 52 diabetics without macroangiopathy, platelet sensitivity to ADP-aggregation was assessed. The sensitivity was expressed by ‘n’ of the minimum effective concentration of serially two-fold diluted ADP, 2-n mg/ml, to give aggregation. In males, both diabetics and healthy, the sensitivity correlated significantly with age. The regression lines obtained were Y=2.15+0,13X (Y: sensitivity, X:age in years) in the diabetics and Y=6.58+0.04X in the healthy subjects respectively. The value of the slope was significantly higher in the diabetics comparing to the healthy subjects. An enhancement of the platelet sensitivity was disclosed significantly in the diabetics but not in the healthy subjects, after isometric handgrip exercise at 50% maximal voluntary contraction for 2 minutes.. This enhancement was prevented when the patients were treated orally with 300 mg of EG-626, 1.5 hours before exercise. These findings would suggest the thrombotic tendency in diabetics and anti-thrombotic effect of this compound.

scholarly journals Increased Glomerular Hydrostatic Pressure is Associated with Tubular Creatinine Reabsorption in Healthy Subjects

2020 ◽  
Vol 45 (6) ◽  
pp. 996-1008
Author(s):  
Akihiro Tsuda ◽  
Eiji Ishimura ◽  
Yuri Machiba ◽  
Hideki Uedono ◽  
Shinya Nakatani ◽  
...  
Keyword(s):  
Hydrostatic Pressure ◽  
Healthy Subjects ◽  
Secretory Component ◽  
Tubular Reabsorption ◽  
Hemodynamic Parameters ◽  
Regression Analyses ◽  
Kidney Donor ◽  
Acid Clearance ◽  
Arteriolar Resistance ◽  
Creatinine Reabsorption

<b><i>Background:</i></b> Cr is secreted by the proximal tubules and thus Cr clearance (<i>C</i><sub>cr</sub>) can overestimate inulin clearance (<i>C</i><sub>in</sub>). However, in some cases, <i>C</i><sub>cr</sub> can even underestimate <i>C</i><sub>in</sub>. This suggests that Cr could be reabsorbed in the tubuli. We examined the clinical parameters that are associated with tubular Cr reabsorption. <b><i>Methods:</i></b> In 80 kidney donor candidates (53.9 ± 13.2 years, 29 males), <i>C</i><sub>in</sub> and para-aminohippuric acid clearance were measured simultaneously. Intrarenal hemodynamic parameters were calculated by Gomez’s formulae. To quantify the secretory component of <i>C</i><sub>cr</sub> (SF<sub>cr</sub>), it was calculated as follows: SF<sub>cr</sub> = (<i>C</i><sub>cr</sub> − <i>C</i><sub>in</sub>)/<i>C</i><sub>cr</sub>. <b><i>Results:</i></b> Twenty-five subjects (31.3%) showed SF<sub>cr</sub> values &#x3c;0. SF<sub>cr</sub> that correlated significantly and negatively with efferent arteriolar resistance (<i>R</i><sub>e</sub>) and glomerular hydrostatic pressure (<i>P</i><sub>glo</sub>) (<i>R</i><sub>e</sub>: <i>r</i> = −0.30, <i>p</i> = 0.008; <i>P</i><sub>glo</sub>: <i>r</i> = −0.28, <i>p</i> = 0.025). In multiple regression analyses, <i>R</i><sub>e</sub> and <i>P</i><sub>glo</sub> were significantly and negatively associated with SF<sub>cr</sub> after adjustment for other confounders. <b><i>Conclusions:</i></b> These findings suggest that tubular reabsorption of Cr can occur in some cases. Intrarenal glomerular hemodynamic burden may be related to tubular creatinine reabsorption, which possibly leads to lower <i>C</i><sub>cr</sub> values.

Effect of histamine and cimetidine on retinal and choroidal blood flow in humans

2005 ◽  
Vol 289 (5) ◽  
pp. R1387-R1391 ◽  
Author(s):  
Hemma Resch ◽  
Claudia Zawinka ◽  
Solveig Lung ◽  
Günther Weigert ◽  
Leopold Schmetterer ◽  
...  
Keyword(s):  
Blood Flow ◽  
Healthy Subjects ◽  
Retinal Vessel ◽  
Blood Velocity ◽  
Laser Doppler ◽  
Hemodynamic Parameters ◽  
Arterial Diameter ◽  
Choroidal Blood Flow ◽  
Pulsation Amplitude ◽  
Venous Diameter

Intravenous administration of histamine causes an increase in choroidal blood flow and retinal vessel diameter in healthy subjects. The mechanism underlying this effect remains to be elucidated. In the present study, we hypothesized that H2 receptor blockade alters hemodynamic effects of histamine in the choroid and retina. Eighteen healthy male nonsmoking volunteers were included in this randomized, double-masked, placebo-controlled two-way crossover study. Histamine (0.32 μg·kg−1·min−1 over 30 min) was infused intravenously in the absence (NaCl as placebo) or presence of the H2 blocker cimetidine (2.3 mg/min over 50 min). Ocular hemodynamic parameters, blood pressure, and intraocular pressure were measured before drug administration, after infusion of cimetidine or placebo, and after coinfusion of histamine. Subfoveal choroidal blood flow and fundus pulsation amplitude were measured with laser-Doppler flowmetry and laser interferometry, respectively. Retinal arterial and venous diameters were measured with a retinal vessel analyzer. Retinal blood velocity was assessed with bidirectional laser-Doppler velocimetry. Histamine increased subfoveal choroidal blood flow (+14 ± 15%, P < 0.001), fundus pulsation amplitude (+11 ± 5%, P < 0.001), retinal venous diameter (+3.0 ± 3.6%, P = 0.002), and retinal arterial diameter (+2.8 ± 4.2%, P < 0.01) but did not change retinal blood velocity. The H2 antagonist cimetidine had no significant effect on ocular hemodynamic parameters. In addition, cimetidine did not modify effects of histamine on choroidal blood flow, fundus pulsation amplitude, retinal venous diameter, and retinal arterial diameter compared with placebo. The present data confirm that histamine increases choroidal blood flow and retinal vessel diameters in healthy subjects. This ocular vasodilator effect of histamine is, however, not altered by administration of an H2 blocker. Whether the increase in blood flow is mediated via H1 receptors or other hitherto unidentified mechanisms remains to be elucidated.

scholarly journals Effects of diaphragmatic contraction on lower limb venous return and central hemodynamic parameters contrasting healthy subjects versus heart failure patients at rest and during exercise

2014 ◽  
Vol 2 (12) ◽  
pp. e12216 ◽  
Author(s):  
Fernanda Machado Balzan ◽  
Régis Chiarelli da Silva ◽  
Danton Pereira da Silva ◽  
Paulo Roberto Stefani Sanches ◽  
Angela Maria Vicente Tavares ◽  
...  
Keyword(s):  
Heart Failure ◽  
Lower Limb ◽  
Healthy Subjects ◽  
Venous Return ◽  
Hemodynamic Parameters ◽  
Heart Failure Patients ◽  
Central Hemodynamic

Reflex Responses in Upper Limb Muscles to Cutaneous Stimuli

1993 ◽  
Vol 20 (04) ◽  
pp. 271-278 ◽  
Author(s):  
R. Chen
Keyword(s):  
Stimulus Intensity ◽  
Upper Limb ◽  
Healthy Subjects ◽  
Voluntary Contraction ◽  
Cutaneous Reflexes ◽  
Focal Lesions ◽  
Normal Ranges ◽  
Conduction Velocities ◽  
Limb Muscles ◽  
Biphasic Responses

ABSTRACT:Cutaneous reflexes in the upper limb were elicited by stimulating digital nerves and recorded by averaging rectified EMG from proximal and distal upper limb muscles during voluntary contraction. Distal muscles often showed a triphasic response: an inhibition with onset about 50 ms (Il) followed by a facilitation with onset about 60 ms (E2) followed by another inhibition with onset about 80 ms (12). Proximal muscles generally showed biphasic responses beginning with facilitation or inhibition with onset at about 40 ms. Normal ranges for the amplitude of these components were established from recordings on 22 arms of 11 healthy subjects. An attempt was made to determine the alterent fibers responsible for the various components by varying the stimulus intensity, by causing ischemic block of larger fibers and by estimating the afferent conduction velocities. The central pathways mediating these reflexes were examined by estimating central delays and by studying patients with focal lesions

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