Performance of non-invasive stroke volume variation during passive leg raise as a predictor of hypotension following induction of spinal anesthesia for elective cesarean delivery: a single cohort study

2021 ◽  
pp. 103251
Author(s):  
G. Duclos ◽  
S. Granier ◽  
A. Hili ◽  
J. Blanc ◽  
S. Einav ◽  
...  
Keyword(s):  
Cohort Study ◽  
Stroke Volume ◽  
Spinal Anesthesia ◽  
Cesarean Delivery ◽  
Stroke Volume Variation ◽  
Elective Cesarean Delivery ◽  
Non Invasive ◽  
Passive Leg Raise ◽  
Elective Cesarean ◽  
Single Cohort

scholarly journals The effects of isobaric and hyperbaric bupivacaine on maternal hemodynamic changes post spinal anesthesia for elective cesarean delivery: A prospective cohort study

PLoS ONE ◽  
2019 ◽  
Vol 14 (12) ◽  
pp. e0226030
Author(s):  
Shamill Eanga Helill ◽  
Wossenyeleh Admasu Sahile ◽  
Ritbano Ahmed Abdo ◽  
Getahun Dendir Wolde ◽  
Hassen Mosa Halil
Keyword(s):  
Cohort Study ◽  
Spinal Anesthesia ◽  
Cesarean Delivery ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Elective Cesarean Delivery ◽  
Hemodynamic Changes ◽  
Hyperbaric Bupivacaine ◽  
Elective Cesarean

β2-Adrenoceptor Genotype Affects Vasopressor Requirements during Spinal Anesthesia for Cesarean Delivery

2006 ◽  
Vol 104 (4) ◽  
pp. 644-650 ◽  
Author(s):  
Richard M. Smiley ◽  
Jean-Louis Blouin ◽  
Maria Negron ◽  
Ruth Landau
Keyword(s):  
Spinal Anesthesia ◽  
Cesarean Delivery ◽  
Analysis Of Variance ◽  
Genetic Variants ◽  
Response To Treatment ◽  
Elective Cesarean Delivery ◽  
Hyperbaric Bupivacaine ◽  
Wide Variability ◽  
Elective Cesarean ◽  
Vasopressor Use

Background Maternal hypotension is common after spinal anesthesia for cesarean delivery. There is wide variability in the incidence and severity of hypotension and in the response to treatment. The beta2 adrenoceptor (beta2AR) possesses several polymorphic sites. Codons 16 (Arg16Gly) and 27 (Glu27Gln) have been shown to affect desensitization of the receptor. The goal of this study was to determine whether genetic variants of the beta2AR alter incidence of hypotension or the amount of vasopressor treatment required during spinal anesthesia for cesarean delivery. Methods One hundred seventy healthy women undergoing elective cesarean delivery were studied. Spinal anesthesia was performed with 12 mg hyperbaric bupivacaine, 25 microg fentanyl, and 200 microg morphine. Hypotension was treated with ephedrine and/or phenylephrine intravenously, and beta2AR genotype at codons 16 and 27 was determined. Analysis of variance was used to compare variables between genotypes, with data expressed as mean +/- SD. Results Ephedrine or phenylephrine was used in more than 90% of patients, with no difference in the incidence of hypotension between beta2AR genotypes. However, there was a significant effect of genotype on the amount of vasopressor required. Gly16 homozygotes received significantly less ephedrine (18 +/- 14 mg) than Arg16 homozygotes (28 +/- 13 mg) and Arg16Gly heterozygotes (30 +/- 20 mg; P = 0.0005). Glu27 homozygotes required significantly less ephedrine than Gln 27 homozygotes (14 +/- 13 vs. 30 +/- 19 mg; P = 0.002). Gln27Glu heterozygotes received less ephedrine than Gln27 homozygotes (23 +/- 16 vs. 30 +/- 19 mg; P = 0.03). Conclusions Glycine at position 16 and/or glutamate at position 27 of the beta2AR leads to lower vasopressor use for treatment of hypotension during spinal anesthesia.

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