Role of Le Fort type I osteotomy approach in juvenile nasopharyngeal angiofibroma

2011 ◽  
Vol 40 (11) ◽  
pp. 1271-1274 ◽  
Author(s):  
R. Singh ◽  
P. Hazarika ◽  
D.R. Nayak ◽  
R. Balakrishnan ◽  
S. Pillai ◽  
...  
Author(s):  
Ravi S. Manogaran ◽  
Arulalan Mathialagan ◽  
Vivek Singh ◽  
Prabhaker Mishra ◽  
Rajat Jain ◽  
...  

Abstract Objectives This study was aimed to understand the usefulness of transarterial angiography and embolization in management of juvenile nasopharyngeal angiofibroma (JNA) and to apply the information obtained to stage the disease, select appropriate surgical approach, predict intraoperative bleeding, and prognosticate the disease. Design This study represents a retrospective review of the patients of JNA with major focus on transarterial angiography and embolization findings and its clinical and surgical implications. Setting The study conducted at a tertiary-care super-specialty referral center. Participants Forty-two patients who had undergone transarterial angiography and embolization followed by surgery over the period of 5 years from July 2015 till February 2019 were participated in this study. Main Outcome Measures Tumor vascular pattern based on transarterial angiography, staging of the disease based on extent and vascular supply, surgical approach selected, and prognosticating the disease were determined from this study. Conclusion Transarterial angiography with embolization becomes a prudent preoperative investigation for management of JNA. It provides a complete three-dimensional map of the tumor with stage-specific vascular pattern, reduces vascularity of the tumor, and predicts the sites from where bleeding can occur intra operatively. Thus, it helps in choosing the appropriate surgical approach aiding in complete tumor removal with minimal bleeding.


1992 ◽  
Vol 85 (4) ◽  
pp. 581-587
Author(s):  
Ibuki Hayashi ◽  
Atsushi Sakakura ◽  
Yuzo Yamamoto ◽  
Kazuo Makimoto ◽  
Hiroaki Takahashi ◽  
...  

2016 ◽  
Vol 130 (10) ◽  
pp. 907-913 ◽  
Author(s):  
A Mishra ◽  
V Singh ◽  
V Verma ◽  
S Pandey ◽  
R Trivedi ◽  
...  

AbstractObjective:A possible role of the APC/beta-catenin pathway in the pathogenesis of sporadic juvenile nasopharyngeal angiofibroma has been suggested. This paper presents its current status and clinical association in our patients.Method:A prospective observational study was conducted at King George Medical University and Central Drug Research Institute, in Lucknow, India. Western blot analysis was undertaken in 16 cases to examine beta-catenin expression. The clinical details were recorded along with follow up observations, to determine associations.Results:Up-regulation of beta-catenin expression was seen in 69 per cent of cases. The clinical variables did not reveal significant differences between patients with extremes of expression (extreme under- vs over-expression). However, absent expression was shown exclusively in young adults aged over 18 years, while enhanced expression was associated with an altered facial profile.Conclusion:Although a beta-catenin association was seen in a subset of our sporadic juvenile nasopharyngeal angiofibroma cases, its expression was not homogeneous. This is in contrast to the Western literature that suggests a universal (homogenous) enhanced expression in the majority. Hence, further research is required to better define its molecular cascade.


1999 ◽  
Vol 92 (12) ◽  
pp. 1315-1320 ◽  
Author(s):  
Norio YAMAMOTO ◽  
Seiji KISHIMOTO ◽  
Hiroyuki KITAMURA ◽  
Shinichi TAKAGITA ◽  
Isao MATSUMOTO ◽  
...  

2008 ◽  
Vol 25 (10) ◽  
pp. 1057-1064 ◽  
Author(s):  
Ying Lin ◽  
Jian-Hua Qiu ◽  
Li Qiao ◽  
Li-Sheng He ◽  
Ding-Jun Zha

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