Hedgehog signaling pathway modulates osteogenic differentiation in novel oxysterol-conditioned rabbit bone marrow stromal cells

2011 ◽  
Vol 40 (10) ◽  
pp. e16
Author(s):  
S.C. Sorice ◽  
A. Hokugo ◽  
K. Fan ◽  
V. Meliton ◽  
P. Zuk ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Osteogenic Differentiation ◽  
Signaling Pathway ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Hedgehog Signaling ◽  
Marrow Stromal Cells ◽  
Hedgehog Signaling Pathway ◽  
Rabbit Bone

Characterization of Growth and Osteogenic Differentiation of Rabbit Bone Marrow Stromal Cells

2006 ◽  
Vol 133 (2) ◽  
pp. 76-83 ◽  
Author(s):  
Jason Roostaeian ◽  
Brian Carlsen ◽  
David Simhaee ◽  
Reza Jarrahy ◽  
Weibiao Huang ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Osteogenic Differentiation ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Marrow Stromal Cells ◽  
Rabbit Bone

In Vitro Study of a Novel Oxysterol for Osteogenic Differentiation on Rabbit Bone Marrow Stromal Cells

2013 ◽  
Vol 132 (1) ◽  
pp. 70e-80e ◽  
Author(s):  
Akishige Hokugo ◽  
Sarah Sorice ◽  
Anisa Yalom ◽  
James C. Lee ◽  
Andrew Li ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Osteogenic Differentiation ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
In Vitro Study ◽  
Marrow Stromal Cells ◽  
Vitro Study ◽  
Rabbit Bone

Synergetic topography and chemistry cues guiding osteogenic differentiation in bone marrow stromal cells through ERK1/2 and p38 MAPK signaling pathway

2018 ◽  
Vol 6 (2) ◽  
pp. 418-430 ◽  
Author(s):  
Xinran Zhang ◽  
Haotian Li ◽  
Chucheng Lin ◽  
Congqin Ning ◽  
Kaili Lin
Keyword(s):  
Bone Marrow ◽  
Osteogenic Differentiation ◽  
Signaling Pathway ◽  
P38 Mapk ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Mapk Signaling ◽  
Marrow Stromal Cells ◽  
Ion Doping ◽  
Mapk Signaling Pathways

Ordered micro-patterned topography and Sr ion doping in HAp synergistically enhance osteogenesis through ERK1/2 and p38 MAPK signaling pathways.

Metallofullerene nanoparticles promote osteogenic differentiation of bone marrow stromal cells through BMP signaling pathway

Nanoscale ◽  
2013 ◽  
Vol 5 (3) ◽  
pp. 1205 ◽  
Author(s):  
Kangning Yang ◽  
Weipeng Cao ◽  
Xiaohong Hao ◽  
Xue Xue ◽  
Jing Zhao ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Osteogenic Differentiation ◽  
Signaling Pathway ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Bmp Signaling ◽  
Marrow Stromal Cells

scholarly journals PS1/γ-Secretase-Mediated Cadherin Cleavage Inducesβ-Catenin Nuclear Translocation and Osteogenic Differentiation of Human Bone Marrow Stromal Cells

2016 ◽  
Vol 2016 ◽  
pp. 1-14 ◽  
Author(s):  
Danielle C. Bonfim ◽  
Rhayra B. Dias ◽  
Anneliese Fortuna-Costa ◽  
Leonardo Chicaybam ◽  
Daiana V. Lopes ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Osteogenic Differentiation ◽  
Signaling Pathway ◽  
Cell Fate ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Bone Repair ◽  
Nuclear Translocation ◽  
Marrow Stromal Cells ◽  
Complex Signaling

Bone marrow stromal cells (BMSCs) are considered a promising tool for bone bioengineering. However, the mechanisms controlling osteoblastic commitment are still unclear. Osteogenic differentiation of BMSCs requires the activation ofβ-catenin signaling, classically known to be regulated by the canonical Wnt pathway. However, BMSCs treatment with canonical Wntsin vitrodoes not always result in osteogenic differentiation and evidence indicates that a more complex signaling pathway, involving cadherins, would be required to induceβ-catenin signaling in these cells. Here we showed that Wnt3a alone did not induce TCF activation in BMSCs, maintaining the cells at a proliferative state. On the other hand, we verified that, upon BMSCs osteoinduction with dexamethasone, cadherins were cleaved by the PS1/γ-secretase complex at the plasma membrane, and this event was associated with an enhancedβ-catenin translocation to the nucleus and signaling. When PS1/γ-secretase activity was inhibited, the osteogenic process was impaired. Altogether, we provide evidence that PS1/γ-secretase-mediated cadherin cleavage has as an important role in controllingβ-catenin signaling during the onset of BMSCs osteogenic differentiation, as part of a complex signaling pathway responsible for cell fate decision. A comprehensive map of these pathways might contribute to the development of strategies to improve bone repair.

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