A two-stage reverse dialysis in vitro dissolution testing method for passive targeted liposomes

2012 ◽  
Vol 426 (1-2) ◽  
pp. 211-218 ◽  
Author(s):  
Xiaoming Xu ◽  
Mansoor A. Khan ◽  
Diane J. Burgess
Keyword(s):  
In Vitro Dissolution ◽  
Dissolution Testing ◽  
Two Stage ◽  
Testing Method ◽  
Reverse Dialysis

scholarly journals In vitro dissolution testing models of ocular implants for posterior segment drug delivery

2021 ◽  
Author(s):  
Muhammad Faris Adrianto ◽  
Febri Annuryanti ◽  
Clive G. Wilson ◽  
Ravi Sheshala ◽  
Raghu Raj Singh Thakur
Keyword(s):  
Drug Release ◽  
Posterior Segment ◽  
In Vitro Dissolution ◽  
Prolonged Treatment ◽  
Term Therapy ◽  
In Vitro Test ◽  
Dissolution Testing ◽  
Vitro Test ◽  
Ocular Implants

AbstractThe delivery of drugs to the posterior segment of the eye remains a tremendously difficult task. Prolonged treatment in conventional intravitreal therapy requires injections that are administered frequently due to the rapid clearance of the drug molecules. As an alternative, intraocular implants can offer drug release for long-term therapy. However, one of the several challenges in developing intraocular implants is selecting an appropriate in vitro dissolution testing model. In order to determine the efficacy of ocular implants in drug release, multiple in vitro test models were emerging. While these in vitro models may be used to analyse drug release profiles, the findings may not predict in vivo retinal drug exposure as this is influenced by metabolic and physiological factors. This review considers various types of in vitro test methods used to test drug release of ocular implants. Importantly, it discusses the challenges and factors that must be considered in the development and testing of the implants in an in vitro setup. Graphical abstract

scholarly journals Automation of dissolution tests

2003 ◽  
Vol 25 (1) ◽  
pp. 7-15 ◽  
Author(s):  
Rolf Rolli
Keyword(s):  
Quality Control ◽  
In Vitro Dissolution ◽  
Pharmaceutical Companies ◽  
Dissolution Testing ◽  
Simultaneous Operation ◽  
Task Forces ◽  
The Core ◽  
Dissolution Tests ◽  
The 1960S

Dissolution testing of drug formulations was introduced in the 1960s and accepted by health regulatory authorities in the 1970s. Since then, the importance of dissolution has grown rapidly as have the number of tests and demands in quality-control laboratories. Recent research works lead to the development of in-vitro dissolution tests as replacements for human and animal bioequivalence studies. For many years, a lot of time and effort has been invested in automation of dissolution tests. There have been a number of in-house solutions from pharmaceutical companies and many have created task forces or even departments to develop automation. Robotic solutions with sequential operation were introduced as well as the simultaneous operation concept developed by SOTAX. Today, pharmaceutical companies focus their resources mainly on the core business and in-house engineering solutions that are very difficult to justify. Therefore, it is important to know the basic considerations in order to plan an automation concept and implement it together with a vendor.

scholarly journals The differences between the branded and generic medicines using solid dosage forms: In-vitro dissolution testing

2012 ◽  
Vol 2 ◽  
pp. 1-8 ◽  
Author(s):  
Mubarak Nasser Al Ameri ◽  
Nanda Nayuni ◽  
K.G. Anil Kumar ◽  
David Perrett ◽  
Arthur Tucker ◽  
...  
Keyword(s):  
Dosage Forms ◽  
In Vitro Dissolution ◽  
Dissolution Testing ◽  
Generic Medicines ◽  
Solid Dosage Forms ◽  
Solid Dosage

3D floating tablets: Appropriate 3D design from the perspective of different in vitro dissolution testing methodologies

2019 ◽  
Vol 567 ◽  
pp. 118433 ◽  
Author(s):  
Kinga Ilyés ◽  
Attila Balogh ◽  
Tibor Casian ◽  
Tamás Igricz ◽  
Enikő Borbás ◽  
...  
Keyword(s):  
In Vitro Dissolution ◽  
Dissolution Testing ◽  
3D Design ◽  
Floating Tablets

In vitro dissolution testing of parenteral aqueous solutions and oily suspensions of paracetamol and prednisolone

2017 ◽  
Vol 532 (1) ◽  
pp. 519-527 ◽  
Author(s):  
Mareike Probst ◽  
Martin Schmidt ◽  
Katharina Tietz ◽  
Sandra Klein ◽  
Werner Weitschies ◽  
...  
Keyword(s):  
Aqueous Solutions ◽  
In Vitro Dissolution ◽  
Dissolution Testing

scholarly journals In Vitro Dissolution Testing to Assess Pharmaceutical Equivalence of Selected Amoxicillin Products Available in Sri Lanka: A Post-Marketing Study

2019 ◽  
Vol 26 (1) ◽  
pp. 56-61
Author(s):  
Dhanusha Thambavita ◽  
Charith M. Jayathilake ◽  
K. D. Darshi Sandamali ◽  
Priyadarshani Galappatthy ◽  
Raveendra Laal Jayakody
Keyword(s):  
Sri Lanka ◽  
In Vitro Dissolution ◽  
Dissolution Testing ◽  
Pharmaceutical Equivalence ◽  
Post Marketing
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