A micro- and nano-structured drug carrier based on biocompatible, hybrid polymeric nanoparticles for potential application in dry powder inhalation therapy

Polymer ◽  
2014 ◽  
Vol 55 (16) ◽  
pp. 4012-4021 ◽  
Author(s):  
Sonia Al-Qadi ◽  
Carmen Remuñán-López
Keyword(s):  
Potential Application ◽  
Polymeric Nanoparticles ◽  
Drug Carrier ◽  
Inhalation Therapy ◽  
Dry Powder Inhalation ◽  
Dry Powder

Polymer coating of carrier excipients modify aerosol performance of adhered drugs used in dry powder inhalation therapy

2012 ◽  
Vol 438 (1-2) ◽  
pp. 150-159 ◽  
Author(s):  
Daniela Traini ◽  
Santo Scalia ◽  
Handoko Adi ◽  
Elisabetta Marangoni ◽  
Paul M. Young
Keyword(s):  
Polymer Coating ◽  
Inhalation Therapy ◽  
Dry Powder Inhalation ◽  
Dry Powder ◽  
Aerosol Performance

scholarly journals Dose administration maneuvers and patient care in tobramycin dry powder inhalation therapy

2018 ◽  
Vol 548 (1) ◽  
pp. 182-191 ◽  
Author(s):  
Francesca Buttini ◽  
Anna Giulia Balducci ◽  
Gaia Colombo ◽  
Fabio Sonvico ◽  
Serena Montanari ◽  
...  
Keyword(s):  
Patient Care ◽  
Inhalation Therapy ◽  
Dry Powder Inhalation ◽  
Dry Powder ◽  
Dose Administration

scholarly journals In-Depth Comparison of Dry Particle Coating Processes Used in DPI Particle Engineering

Pharmaceutics ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 580
Author(s):  
Nicholas Bungert ◽  
Mirjam Kobler ◽  
Regina Scherließ
Keyword(s):  
Drug Carrier ◽  
Magnesium Stearate ◽  
High Shear ◽  
Particle Engineering ◽  
Dry Powder Inhalation ◽  
Particle Coating ◽  
Lower Drug ◽  
Dry Particle Coating ◽  
Coarse Model ◽  
Carrier Systems

High-shear mixer coatings as well as mechanofusion processes are used in the particle-engineering of dry powder inhalation carrier systems. The aim of coating the carrier particle is usually to decrease carrier–drug adhesion. This study comprises the in-depth comparison of two established dry particle coating options. Both processes were conducted with and without a model additive (magnesium stearate). In doing so, changes in the behaviour of the processed particles can be traced back to either the process or the additive. It can be stated that the coarse model carrier showed no significant changes when processed without additives. By coating the particles with magnesium stearate, the surface energy decreased significantly. This leads to a significant enhancement of the aerodynamic performance of the respective carrier-based blends. Comparing the engineered carriers with each other, the high-shear mixer coating shows significant benefits, namely, lower drug–carrier adhesion and the higher efficiency of the coating process.

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