Microenvironmental pH modifying films for buccal delivery of saquinavir: Effects of organic acids on pH and drug release in vitro

2020 ◽  
Vol 585 ◽  
pp. 119567 ◽  
Author(s):  
Shaolong He ◽  
Jesper Østergaard ◽  
Madina Ashna ◽  
Carsten Uhd Nielsen ◽  
Jette Jacobsen ◽  
...  
Keyword(s):  
Drug Release ◽  
Organic Acids ◽  
Buccal Delivery ◽  
Microenvironmental Ph ◽  
Release In Vitro

scholarly journals Drug-Eluting Biodegradable Implants for the Sustained Release of Bisphosphonates

Polymers ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 2930
Author(s):  
Cintya Dharmayanti ◽  
Todd A. Gillam ◽  
Desmond B. Williams ◽  
Anton Blencowe
Keyword(s):  
Drug Release ◽  
Release Profile ◽  
Polymer Chains ◽  
Poly Lactic Acid ◽  
Initial Surface ◽  
Sustained Drug Release ◽  
Drug Eluting ◽  
Release In Vitro ◽  
Poor Absorption

Despite being one of the first-line treatments for osteoporosis, the bisphosphonate drug class exhibits an extremely low oral bioavailability (<1%) due to poor absorption from the gastrointestinal tract. To overcome this, and to explore the potential for sustained drug release, bioerodible poly(lactic acid) (PLA) and poly(D,L-lactide-co-glycolide) (PLGA) implants loaded with the bisphosphonate alendronate sodium (ALN) were prepared via hot-melt extrusion. The rate of drug release in vitro was modulated by tailoring the ratio of lactide to glycolide in the polymer and by altering the ALN-loading of the implants. All investigated implants exhibited sustained ALN release in vitro between 25 to 130 days, where implants of greater glycolide composition and higher ALN-loadings released ALN more rapidly. All PLGA implants demonstrated a sigmoidal release profile, characterised by an initial surface dissolution phase, followed by a period of zero-order drug diffusion, then relaxation or erosion of the polymer chains that caused accelerated release over the subsequent days. Contrastingly, the PLA implants demonstrated a logarithmic release profile, characterised by a gradual decrease in ALN release over time.

PEG−Doxorubicin Conjugates:  Influence of Polymer Structure on Drug Release, in Vitro Cytotoxicity, Biodistribution, and Antitumor Activity

2005 ◽  
Vol 16 (4) ◽  
pp. 775-784 ◽  
Author(s):  
Francesco M Veronese ◽  
Oddone Schiavon ◽  
Gianfranco Pasut ◽  
Raniero Mendichi ◽  
Lars Andersson ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Drug Release ◽  
Polymer Structure ◽  
In Vitro Cytotoxicity ◽  
Release In Vitro

NIR-Responsive Copolymer Upconversion Nanocomposites for Triggered Drug Release in Vitro and in Vivo

2018 ◽  
Vol 2 (1) ◽  
pp. 495-503 ◽  
Author(s):  
Yeye Zhang ◽  
Guangzhao Lu ◽  
Yuan Yu ◽  
He Zhang ◽  
Jie Gao ◽  
...  
Keyword(s):  
Drug Release ◽  
Triggered Drug Release ◽  
Release In Vitro

Real-time monitoring of anticancer drug release in vitro and in vivo on titania nanoparticles triggered by external glutathione

Talanta ◽  
2012 ◽  
Vol 88 ◽  
pp. 631-637 ◽  
Author(s):  
Mira Kim ◽  
Ji Hye Seo ◽  
Won Il Jeon ◽  
Mi-Yeon Kim ◽  
Keunchang Cho ◽  
...  
Keyword(s):  
Drug Release ◽  
Real Time ◽  
Anticancer Drug ◽  
Titania Nanoparticles ◽  
Real Time Monitoring ◽  
Release In Vitro

Preparation, characterization, and drug release in vitro of chitosan-glycyrrhetic acid nanoparticles

2006 ◽  
Vol 95 (1) ◽  
pp. 181-191 ◽  
Author(s):  
Yongli Zheng ◽  
Yan Wu ◽  
Wuli Yang ◽  
Changchun Wang ◽  
Shoukuan Fu ◽  
...  
Keyword(s):  
Drug Release ◽  
Glycyrrhetic Acid ◽  
Release In Vitro

The effect of HPMC and MC as pore formers on the rheology of the implant microenvironment and the drug release in vitro

2017 ◽  
Vol 177 ◽  
pp. 433-442 ◽  
Author(s):  
Johanna Aho ◽  
Amanda Halme ◽  
Johan Boetker ◽  
Jorrit Jeroen Water ◽  
Adam Bohr ◽  
...  
Keyword(s):  
Drug Release ◽  
Release In Vitro
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