scholarly journals Indirect monitoring of ultralow dose API content in continuous wet granulation and tableting by machine vision

2021 ◽  
pp. 121008
Author(s):  
Máté Ficzere ◽  
Lilla Alexandra Mészáros ◽  
Lajos Madarász ◽  
Márk Novák ◽  
Zsombor Kristóf Nagy ◽  
...  
Keyword(s):  
Machine Vision ◽  
Wet Granulation ◽  
Ultralow Dose

scholarly journals Continuous Manufacturing of Homogeneous Ultralow-Dose Granules by Twin-Screw Wet Granulation

2020 ◽  
Vol 64 (4) ◽  
pp. 391-400 ◽  
Author(s):  
Balázs Démuth ◽  
Gergő Fülöp ◽  
Márk Kovács ◽  
Lajos Madarász ◽  
Máté Ficzere ◽  
...  
Keyword(s):  
Potato Starch ◽  
Wet Granulation ◽  
Content Uniformity ◽  
Peristaltic Pump ◽  
Continuous Manufacturing ◽  
Ultralow Dose ◽  
Drug Content ◽  
Relative Standard ◽  
Twin Screw ◽  
Measured Mass

Homogeneous ultralow-dose (30 mg) tablets were prepared from perfectly free-flowing granules manufactured by continuous Twin-Screw Wet Granulation. The gravimetrically fed mixture of lactose and potato starch of low particle size was successfully agglomerated and the size enlargement technology proved to be very robust. Since the incorporated drug was dissolved in ethanol-based granulation liquid, the resulting homogeneity largely depended on the dosing of the applied liquid administering units.A peristaltic pump generated higher deviation of the drug content in tablets (Relative Standard Deviation (RSD): 7.7 %) compared to a syringe pump (RSD: 2.3 %) or a piston pump (RSD: 4.6 %). This is due to the pulsation of the liquid flow generated by the peristaltic pump according to the real-time measured mass of the fed liquid. A good correlation was found between the RSD of the liquid mass flow (calculated from the recorded masses) and the RSD of the drug content. Based on the results, the goodness of Content Uniformity, as the most relevant critical quality attribute of low-dose products, was determined by the characteristics of the applied dosing units. The feeding characteristic of the different pumps could be easily measured by the introduced balance-based method and therefore, the applicability of the pumps could be evaluated.

Machine Vision

2009 ◽  
Author(s):  
Wesley E. Snyder ◽  
Hairong Qi
Keyword(s):  
Machine Vision

Ultralow Dose CT Imaging for Navigated Skull Base Surgery Using ASIR and MBIR-2D and 3D Image Quality

2014 ◽  
Vol 75 (S 02) ◽  
Author(s):  
Gerlig Widmann ◽  
P. Schullian ◽  
R. Hoermann ◽  
E. Gassner ◽  
H. Riechelmann ◽  
...  
Keyword(s):  
Image Quality ◽  
Skull Base ◽  
Skull Base Surgery ◽  
Ct Imaging ◽  
3D Image ◽  
Ultralow Dose ◽  
2D And 3D

Classroom Lighting Energy-Saving Control System Based on Machine Vision Technology

2018 ◽  
pp. 143-149 ◽  
Author(s):  
Ruijie CHENG
Keyword(s):  
Control System ◽  
Machine Vision ◽  
Energy Saving ◽  
Back Propagation ◽  
Back Propagation Neural Network ◽  
Lighting Control ◽  
Lighting Energy ◽  
Neural Network Algorithm ◽  
Energy Saving Control ◽  
Model Algorithm

In order to further improve the energy efficiency of classroom lighting, a classroom lighting energy saving control system based on machine vision technology is proposed. Firstly, according to the characteristics of machine vision design technology, a quantum image storage model algorithm is proposed, and the Back Propagation neural network algorithm is used to analyze the technology, and a multi­feedback model for energy­saving control of classroom lighting is constructed. Finally, the algorithm and lighting model are simulated. The test results show that the design of this paper can achieve the optimization of the classroom lighting control system, different number of signals can comprehensively control the light and dark degree of the classroom lights, reduce the waste of resources of classroom lighting, and achieve the purpose of energy saving and emission reduction. Technology is worth further popularizing in practice.

Machine Vision, Let's Go into the Street

1997 ◽  
Vol 117 (10) ◽  
pp. 1339-1344
Author(s):  
Katsuhiko Sakaue ◽  
Hiroyasu Koshimizu
Keyword(s):  
Machine Vision

Machine Vision Technologies to Connect with Humans

2005 ◽  
Vol 125 (11) ◽  
pp. 692-695
Author(s):  
Kazunori UMEDA ◽  
Yoshimitsu AOKI
Keyword(s):  
Machine Vision

INVESTIGATION OF BEE BREAD AND DEVELOPMENT OF ITS DOSAGE FORMS

2014 ◽  
Vol 21 (1) ◽  
pp. 16-22 ◽  
Author(s):  
Ilze Barene ◽  
Irena Daberte ◽  
Sanita Siksna
Keyword(s):  
Thin Layer ◽  
Thin Layer Chromatography ◽  
Potato Starch ◽  
Microscopic Analysis ◽  
Stability Study ◽  
Ion Concentration ◽  
Wet Granulation ◽  
Hydrogen Ion Concentration ◽  
Bee Bread ◽  
Layer Chromatography

The aim of the study. The objective of this study was to investigate microscopic, physical and chemical properties of bee bread collected in three regions of Latvia in order to compare the quality and to investigate the possibility of producing granules containing bee bread. Material and methods. Microscopic analysis of bee bread samples was performed. Plant herbaria, special literature and internet sources were used for identification of pollen. Thin layer chromatography was used for identification of carotenoids and flavonoids. Granules were prepared by wet granulation method. Lactose, calcium lactate, calcium carbonate, potato starch and purified water were used as excipients. Appearance, loss on drying, pH of aqueous solution and content of carotenes were estimated. Results. Microscopic analysis showed mostly native pollen identified as willow pollen. Beta-carotene identified and 2 carotenoids found by thin layer chromatography. Two zones of flavonoids found on chromatograms at day light and 6 zones at ultra violet light. The comparison of bee bread samples of 3 regions of Latvia showed insignificant differences in appearance and consistency, hydrogen ion concentration 3.93–4.23, loss on drying 7.72–11.07 %; content of carotenes calculated to bcarotene 6.77–9.35 mg%. Stability study of bee bread samples showed greater changes after storage at 40ºC temperature. All compositions of granules showed appropriate appearance and flowability. Quality of granules: loss on drying 5.48–13.5%, content of carotenes calculated to b-carotene 5.77–6.75 mg%. Conclusions. Pollen of willow can be considered as an indicator of the origin of bee bread in Latvia. Bee bread samples of three regions of Latvia have insignificant differences in physical, chemical parameters.

Multifunctional stereoscopic machine vision system with multiple 3D outputs

2020 ◽  
Keyword(s):  
Machine Vision ◽  
International Symposium ◽  
Fast Track ◽  
Vision System ◽  
Machine Vision System ◽  
Stereoscopic Displays ◽  
Electronic Imaging

Fast track article for IS&T International Symposium on Electronic Imaging 2020: Stereoscopic Displays and Applications proceedings.

A Flying Gray Ball Multi-illuminant Image Dataset for Color Research

2020 ◽  
Vol 64 (5) ◽  
pp. 50411-1-50411-8
Author(s):  
Hoda Aghaei ◽  
Brian Funt
Keyword(s):  
Machine Vision ◽  
Spectral Reflectance ◽  
Color Constancy ◽  
Ground Truth ◽  
Practical Approach ◽  
Post Processing ◽  
Illumination Estimation ◽  
Processing Step ◽  
Image Dataset

Abstract For research in the field of illumination estimation and color constancy, there is a need for ground-truth measurement of the illumination color at many locations within multi-illuminant scenes. A practical approach to obtaining such ground-truth illumination data is presented here. The proposed method involves using a drone to carry a gray ball of known percent surface spectral reflectance throughout a scene while photographing it frequently during the flight using a calibrated camera. The captured images are then post-processed. In the post-processing step, machine vision techniques are used to detect the gray ball within each frame. The camera RGB of light reflected from the gray ball provides a measure of the illumination color at that location. In total, the dataset contains 30 scenes with 100 illumination measurements on average per scene. The dataset is available for download free of charge.

Formulation and Evaluation of Fast Disintigrating Meloxicam Tablets and Its Comparison with Marketed Product

2010 ◽  
Vol 2 (2) ◽  
Author(s):  
Suresh Kulkarni ◽  
Ranjit P. ◽  
Nikunj Patel ◽  
Someshwara B. ◽  
Ramesh B. ◽  
...  
Keyword(s):  
Water Absorption ◽  
In Vitro Dissolution ◽  
Thickness Variation ◽  
Wet Granulation ◽  
Disintegration Time ◽  
Absorption Ratio ◽  
Wetting Time ◽  
Fast Disintegrating Tablets ◽  
Cox 1

The present investigation deals with the formulation of fast disintegrating tablets of Meloxicam that disintegrate in the oral cavity upon contact with saliva and there by improve therapeutic efficacy. Meloxicam is a newer selective COX-1 inhibitor. The tablets were prepared by wet granulation procedure. The influence of superdisintegrants, crosspovidone, croscaremellose sodium on disintegration time, wetting time and water absorption ratio were studied. Tablets were evaluated for weight and thickness variation, disintegration time, drug content, in vitro dissolution, wetting time and water absorption ratio. The in vitro disintegration time of the best fast disintegrating tablets was found to be 18 sec. Tablets containing crospovidone exhibit quick disintegration time than tablets containing croscaremellose sodium. The fast disintegrating tablets of Meloxicam with shorter disintegration time, acceptable taste and sufficient hardness could be prepared using crospovidone and other excipients at optimum concentration.

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