A Dual-Delivery Platform for Vaccination using Antigen-loaded Nanoparticles in Dissolving Microneedles

2021 ◽  
pp. 121393
Author(s):  
Keegan Braz Gomes ◽  
Bernadette D'Souza ◽  
Sharon Vijayanand ◽  
Ipshita Menon ◽  
Martin J. D'Souza
Keyword(s):  
Dissolving Microneedles ◽  
Delivery Platform

scholarly journals Rapidly Separable Micropillar Integrated Dissolving Microneedles

Pharmaceutics ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 581 ◽  
Author(s):  
Chung-ryong Jung ◽  
Shayan Fakhraei Lahiji ◽  
Youseong Kim ◽  
Hyeonjun Kim ◽  
Hyungil Jung
Keyword(s):  
Drug Delivery ◽  
Elastic Properties ◽  
Transdermal Delivery ◽  
Injury Risk ◽  
High Efficiency ◽  
Delivery Systems ◽  
Skin Injury ◽  
Dissolving Microneedles ◽  
Delivery Platform

Dissolving microneedle (DMN) patches were developed as efficient and patient-friendly transdermal delivery systems for biopharmaceuticals. However, recent studies have confirmed that the efficiency of DMNs to deliver biopharmaceuticals is highly reduced because of incomplete insertion caused by the stiffness and elastic properties of the skin. Therefore, micropillar integrated DMNs were developed to overcome the insertion limitations of DMN patches. Although micropillars were designed as integrated applicators to implant DMNs across the skin, they can also become inserted into the skin, leading to skin injury and inflammation. Herein, we have developed a separable micropillar integrated DMN (SPDMN) capable of inserting DMNs across the skin with high efficiency while minimizing skin injury risk through the introduction of a safety ring feature. Unlike previously developed systems, the SPDMN does not require continuous skin attachment and can be detached immediately post-application, leaving DMNs implanted inside the skin. Altogether, the findings of this study lead to the development of a quick, safe, and efficient DMN-based drug delivery platform.

HPMC/PVP Dissolving Microneedles: a Promising Delivery Platform to Promote Trans-Epidermal Delivery of Alpha-Arbutin for Skin Lightening

2019 ◽  
Vol 21 (1) ◽  
Author(s):  
Nway Nway Aung ◽  
Tanasait Ngawhirunpat ◽  
Theerasak Rojanarata ◽  
Prasopchai Patrojanasophon ◽  
Praneet Opanasopit ◽  
...  
Keyword(s):  
Dissolving Microneedles ◽  
Delivery Platform ◽  
Skin Lightening

Faster Deliveries and Smarter Order Assignments for an On-Demand Meal Delivery Platform

2019 ◽  
Author(s):  
Wenzheng Mao ◽  
Liu Ming ◽  
Ying Rong ◽  
Christopher S. Tang ◽  
Huan Zheng
Keyword(s):  
On Demand ◽  
Delivery Platform ◽  
Meal Delivery

Hydrogel-clay Nanocomposites as Carriers for Controlled Release

2020 ◽  
Vol 27 (6) ◽  
pp. 919-954 ◽  
Author(s):  
Raluca Ianchis ◽  
Claudia Mihaela Ninciuleanu ◽  
Ioana Catalina Gifu ◽  
Elvira Alexandrescu ◽  
Cristina Lavinia Nistor ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Hybrid Materials ◽  
Pharmaceutical Formulations ◽  
Tree Of Life ◽  
Present Review ◽  
Clay Nanocomposites ◽  
Delivery Platform ◽  
Complex Hybrid

The present review aims to summarize the research efforts undertaken in the last few years in the development and testing of hydrogel-clay nanocomposites proposed as carriers for controlled release of diverse drugs. Their advantages, disadvantages and different compositions of polymers/biopolymers with diverse types of clays, as well as their interactions are discussed. Illustrative examples of studies regarding hydrogel-clay nanocomposites are detailed in order to underline the progressive researches on hydrogel-clay-drug pharmaceutical formulations able to respond to a series of demands for the most diverse applications. Brief descriptions of the different techniques used for the characterization of the obtained complex hybrid materials such as: swelling, TGA, DSC, FTIR, XRD, mechanical, SEM, TEM and biology tests, are also included. Enlightened by the presented data, we can suppose that hydrogel-clay nanocomposites will still be a challenging subject of global assiduous researches. We can dare to dream to an efficient drug delivery platform for the treatment of multiple affection concomitantly, these being undoubtedly like ”a tree of life” bearing different kinds of fruits and leaves proper for human healing.

scholarly journals Illusory freedom of physical platform workers: Insights from Uber Eats in Japan

2021 ◽  
pp. 103530462199246
Author(s):  
Hamza Umer
Keyword(s):  
Comparative Analysis ◽  
Collective Bargaining ◽  
Food Delivery ◽  
Jel Codes ◽  
Delivery Platform ◽  
Pros And Cons

Platform work is often advocated as offering freedom of work to labour. Contesting this claim, this article undertakes a comparative analysis of the pros and cons of food delivery platform work prior to and during the COVID-19 pandemic, and argues that the freedom of food delivery platform workers is essentially an ‘illusory freedom’. In reality, platform work has only changed mechanisms through which companies can exercise control over labour and evade their employer obligations. As a case, the article examines the illusory freedom of food delivery platform workers associated to Uber Eats in Japan. The collective bargaining efforts of food delivery workers against the excessive control of Uber Eats and the extent of success of these efforts are also examined. The article concludes by discussing the possible factors that have undermined the effectiveness of the collective bargaining efforts of the labour union. JEL Codes: J52; J81

Exosomes as targeted delivery platform of CRISPR/Cas9 for therapeutic genome editing

ChemBioChem ◽  
2021 ◽  
Author(s):  
Li Duan ◽  
Kan Ouyang ◽  
Jianhong Wang ◽  
Limei Xu ◽  
Xiao Xu ◽  
...  
Keyword(s):  
Genome Editing ◽  
Targeted Delivery ◽  
Delivery Platform

scholarly journals Flow-dependent regulation of endothelial Tie2 by GATA3 in vivo

2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Temitayo O. Idowu ◽  
Valerie Etzrodt ◽  
Thorben Pape ◽  
Joerg Heineke ◽  
Klaus Stahl ◽  
...  
Keyword(s):  
Gene Expression ◽  
Regulation Of Gene Expression ◽  
Experimental Models ◽  
Common Denominator ◽  
Dependent Manner ◽  
Pulmonary Endothelium ◽  
Delivery Platform ◽  
Transient Overexpression ◽  
Plasmid Delivery

Abstract Background Reduced endothelial Tie2 expression occurs in diverse experimental models of critical illness, and experimental Tie2 suppression is sufficient to increase spontaneous vascular permeability. Looking for a common denominator among different critical illnesses that could drive the same Tie2 suppressive (thereby leak inducing) phenotype, we identified “circulatory shock” as a shared feature and postulated a flow-dependency of Tie2 gene expression in a GATA3 dependent manner. Here, we analyzed if this mechanism of flow-regulation of gene expression exists in vivo in the absence of inflammation. Results To experimentally mimic a shock-like situation, we developed a murine model of clonidine-induced hypotension by targeting a reduced mean arterial pressure (MAP) of approximately 50% over 4 h. We found that hypotension-induced reduction of flow in the absence of confounding disease factors (i.e., inflammation, injury, among others) is sufficient to suppress GATA3 and Tie2 transcription. Conditional endothelial-specific GATA3 knockdown (B6-Gata3tm1-Jfz VE-Cadherin(PAC)-cerERT2) led to baseline Tie2 suppression inducing spontaneous vascular leak. On the contrary, the transient overexpression of GATA3 in the pulmonary endothelium (jet-PEI plasmid delivery platform) was sufficient to increase Tie2 at baseline and completely block its hypotension-induced acute drop. On the functional level, the Tie2 protection by GATA3 overexpression abrogated the development of pulmonary capillary leakage. Conclusions The data suggest that the GATA3–Tie2 signaling pathway might play a pivotal role in controlling vascular barrier function and that it is affected in diverse critical illnesses with shock as a consequence of a flow-regulated gene response. Targeting this novel mechanism might offer therapeutic opportunities to treat vascular leakage of diverse etiologies.

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