Adrenal hormone response and psychophysiological correlates under psychosocial stress in individuals with irritable bowel syndrome

BackgroundDespite stress being considered a key factor in the pathophysiology of the functional gastrointestinal (GI) disorder irritable bowel syndrome (IBS), there is a paucity of information regarding the ability of IBS patients to respond to acute experimental stress. Insights into the stress response in IBS could open the way to novel therapeutic interventions. To this end, we assessed the response of a range of physiological and psychological parameters to the Trier Social Stress Test (TSST) in IBS.MethodThirteen female patients with IBS and 15 healthy female age-matched control participants underwent a single exposure to the TSST. Salivary cortisol, salivary C-reactive protein (CRP), skin conductance level (SCL), GI symptoms, mood and self-reported stress were measured pre- and post-exposure to the TSST.ResultsThe hypothalamic–pituitary–adrenal (HPA) axis response to the TSST was sustained in IBS, as shown by a greater total cortisol output throughout (p = 0.035) and higher cortisol levels measured by an area under the curve with respect to ground (AUCG) analysis (p = 0.044). In IBS patients, GI symptoms increased significantly during the recovery period following exposure to the TSST (p = 0.045). Salivary CRP and SCL activity showed significant changes in relation to stress but with no differential effect between experimental groups.ConclusionsPatients with IBS exhibit sustained HPA axis activity, and an increase in problematic GI symptoms in response to acute experimental psychosocial stress. These data pave the way for future interventional studies aimed at identifying novel therapeutic approaches to modulate the HPA axis and GI symptom response to acute psychosocial stress in IBS.

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Intake of Fermentable Oligo-, Di- and Mono-saccharides And Polyols (FODMAPs) increases the risk of Irritable Bowel Syndrome (IBS) in individuals exposed to psychosocial stress in the community: results of a large, prospective, population based study

10.26226/morressier.59a6b34cd462b80290b55ad1 ◽

2017 ◽

Author(s):

Mark Fox

Keyword(s):

Irritable Bowel Syndrome ◽

Psychosocial Stress ◽

Population Based ◽

Population Based Study ◽

Irritable Bowel

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Chang-Kang-Fang Ameliorates Experimental Diarrhea Predominant Irritable Bowel Syndrome by Regulating Gut Microbiota and Gut -Brain Axis

10.21203/rs.3.rs-22131/v1 ◽

2020 ◽

Author(s):

Hui Xie ◽

Min Lu ◽

Xinyu Fan ◽

Jingyi Hu ◽

Yuanyuan Zheng ◽

...

Keyword(s):

Irritable Bowel Syndrome ◽

Body Weight ◽

Gut Microbiota ◽

Therapeutic Effect ◽

Rat Model ◽

Psychosocial Stress ◽

Body Weight Change ◽

Withdrawal Reflex ◽

Peripheral Stimulation ◽

Irritable Bowel

Abstract Background: Chang-Kang-Fang formula (CKF), a multi-herb traditional Chinese medicinal formula, has been clinically used for treatment of irritable bowel syndrome with diarrhea (IBS-D). Though we have reported the compounds of CKF and the therapeutic effect on IBS-D rats, the exact mechanism underlying is still not clear. The aim of this study is to clearly define the effect of CKF on IBS-D by regulating gut microbiota and gut-brain axis. Method: We investigated the effects of CKF on IBS-D rat model, established by psychosocial stress (restraint) combined with the peripheral stimulation (senna leaf gavage) stress. The changed of body weight and the number of fecal pellets was investigated during the experiment. The effect on intestinal sensitivity was assessed based on the abdominal withdrawal reflex (AWR) scores and the intestinal permeability, the expression of ZO-1, measured by immunohistochemistry. The effect of CKF on gut-brain axis was evaluated by the expression of 5-HT through immunohistochemistry. The composition of gut microbiota was detected through 16sRNA. Results: Administration of CKF significantly have shown the therapeutic effect on IBS-D rats, involving decreased the score of AWR and increased the number of pellets, though there were no different on body weight change. In addition, CKF could upregulated the expression of ZO-1 in colon and downregulated the expression of 5-HT in colon and brain Moreover, CKF could rebalance the gut microbiota of IBS-D, increasing the abundance of Lactobacillu, Allobaculum, Roseburia and Lachnospiraceae_NK4A136. Conclusion: CKF potentially alleviates IBS-D through regulating gut microbiota and gut-brain axis.

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