scholarly journals Investigating the Role of Excipients on the Physical Stability of Directly Compressed Tablets

2021 ◽  
pp. 100106
Author(s):  
Natalie Maclean ◽  
Ibrahim Khadra ◽  
James Mann ◽  
Helen Williams ◽  
Alexander Abbott ◽  
...  
Keyword(s):  
Physical Stability

Thermodynamic Principles for the Design of Polymers for Drug Formulations

2019 ◽  
Vol 10 (1) ◽  
pp. 311-335
Author(s):  
Michael Fischlschweiger ◽  
Sabine Enders
Keyword(s):  
Physical Stability ◽  
Ultrahigh Molecular Weight Polyethylene ◽  
Drug Formulation ◽  
Sufficient Time ◽  
Delivery Methods ◽  
Drug Solubilization ◽  
Drug Candidates ◽  
Ultrahigh Molecular Weight ◽  
Amorphous Dispersions

Polymers play an essential role in drug formulation and production of medical devices, implants, and diagnostics. Following drug discovery, an appropriate formulation is selected to enable drug delivery. This task can be exceedingly challenging owing to the large number of potential delivery methods and formulation and process variables that can interact in complex ways. This evolving solubility challenge has inspired an increasing emphasis on the developability of drug candidates in early discovery as well as various advanced drug solubilization strategies. Among the latter, formulation approaches that lead to prolonged drug supersaturation to maximize the driving force for sustained intestinal absorption of an oral product, or to allow sufficient time for injection after reconstitution of a parenteral lyophile formulation, have attracted increasing interest. Although several kinetic and thermodynamic components are involved in stabilizing amorphous dispersions, it is generally assumed that maximum physical stability, defined in terms of inhibition of drug crystallization, requires that the drug and excipient remain intimately mixed. Phase separation of the drug from its excipient may be the first step that ultimately leads to crystallization. We discuss the role of advanced thermodynamics using two examples: ASD and vitamin E–stabilized ultrahigh–molecular weight polyethylene implants.

scholarly journals The perception of physical stability of 3D objects: The role of parts

2010 ◽  
Vol 10 (7) ◽  
pp. 77-77 ◽  
Author(s):  
S. A. Cholewiak ◽  
M. Singh ◽  
R. Fleming ◽  
B. Pastakia
Keyword(s):  
Physical Stability ◽  
3D Objects

scholarly journals Studies of the Effect of Storage Conditions on Some Pharmaceutical Parameters of Powders and Tablets

2016 ◽  
Vol 14 (2) ◽  
pp. 147-151
Author(s):  
Bakre Lateef Gbenga ◽  
Yusuf Taiwo
Keyword(s):  
Prolonged Exposure ◽  
Corn Starch ◽  
Physical Stability ◽  
Storage Period ◽  
Storage Conditions ◽  
Angle Of Repose ◽  
Pharmaceutical Powders ◽  
Before And After ◽  
Tablet Hardness

This study evaluates the effect of storage conditions on some pharmaceutical parameters of powders (paracetamol, corn starch, tragacanth and polyvinyl pyrrolidone) and tablets (paracetamol, metronidazole and vitamin C). For powdered samples, angle of repose, bulk and tapped densities were determined while the tablets were evaluated for hardness, friability and disintegration before and after exposure to various humidity conditions, radiations from telecommunication mast and sunlight at intervals of 24 hrs & 1, 2, 4 and 8 weeks. The results showed a decrease in the angle of repose for paracetamol, corn starch, polyvinyl pyrollidone and tragacanth powders on exposure to sunlight. There was no significant (p>0.05) change in the tapped and bulk densities under the different storage conditions over the storage period. No organoleptic changes were observed for any of the samples stored under the environmental conditions over the two-month period. All the tablets stored over the two- month period conformed to the official BP standard for weight uniformity. Paracetamol tablets exposed to 93% relative humidity (RH) showed significantly lower reduction (P<0.05) in hardness compared to the other storage conditions. On prolonged exposure of paracetamol and metronidazole tablets to radiation from telecommunication mast, there was a reduction in tablet hardness and the tablets became friable. The observations of the present study reconfirm the role of storage conditions in ensuring the physical stability of pharmaceutical powders and tablets.\Dhaka Univ. J. Pharm. Sci. 14(2): 147-151, 2015 (December)

Role of moisture on the physical stability of polymorphic olanzapine

2016 ◽  
Vol 509 (1-2) ◽  
pp. 135-148 ◽  
Author(s):  
Maria C. Paisana ◽  
Martin A. Wahl ◽  
João F. Pinto
Keyword(s):  
Physical Stability
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