scholarly journals Adaptive Radiation Therapy for Head and Neck Cancers: A Veterans Affairs Single-Institution Experience

2016 ◽  
Vol 96 (2) ◽  
pp. E339-E340
Author(s):  
B.K. Lee ◽  
J. Zhang ◽  
J.J. Cho-Lim ◽  
W.S. Inouye ◽  
S.P. Lee
Keyword(s):  
Radiation Therapy ◽  
Head And Neck ◽  
Adaptive Radiation ◽  
Veterans Affairs ◽  
Head And Neck Cancers ◽  
Adaptive Radiation Therapy ◽  
Single Institution

Adaptive Radiation Therapy in Head and Neck Cancers: When Should we Re-plan?

2011 ◽  
Vol 81 (2) ◽  
pp. S494-S495
Author(s):  
F. Siddiqui ◽  
D. Boyle ◽  
M. Weldon ◽  
M. McGee ◽  
K. Kuhn ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Head And Neck ◽  
Adaptive Radiation ◽  
Head And Neck Cancers ◽  
Adaptive Radiation Therapy

Postradiation hypothyroidism in head and neck cancers: A Department of Veterans Affairs single-institution case-control dosimetry study

2019 ◽  
Vol 44 (1) ◽  
pp. 56-60
Author(s):  
Alexander J. Lin ◽  
Juying Zhang ◽  
Jennie Cho-Lim ◽  
Warren Inouye ◽  
Steve P. Lee
Keyword(s):  
Head And Neck ◽  
Case Control ◽  
Veterans Affairs ◽  
Head And Neck Cancers ◽  
Department Of Veterans Affairs ◽  
Single Institution

Towards adaptive radiation therapy: Image-based tumor shrinkage modeling in head and neck cancer

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. e17050-e17050
Author(s):  
M. Chao ◽  
Y. Xie ◽  
Q. Le ◽  
L. Xing
Keyword(s):  
Radiation Therapy ◽  
Tumor Growth ◽  
Head And Neck ◽  
Adaptive Radiation ◽  
Spline Interpolation ◽  
Adaptive Radiation Therapy ◽  
Phantom Experiment ◽  
Feature Correspondence ◽  
Planning Ct ◽  
Clinical Cases

e17050 Background: Understanding the kinetics of tumor growth/shrinkage represents a critical step in quantitative assessment of therapeutics and realization of adaptive radiation therapy. We established a novel framework for image-based modeling of tumor change and demonstrate its performance with a number of synthetic images and clinical cases. Methods: Due to the nonconservation of tissue, similarity-based deformable models are not suitable for describing the tumor growth/shrinkage process. Under the hypothesis that the tissue features in the tumor volume or the boundary region are partially preserved, we model the tumor kinetics by a two-step procedure: (1) auto-detection of homologous tissue features shared by the planning CT and subsequent on-treatment CBCT images using the Scale Invariance Feature Transformation (SIFT) method; (2) establishment of voxel-to-voxel correspondence between two input images for the remaining spatial points by a basis spline interpolation. The correctness of the tissue feature correspondence is doubly assured by a bi-directional association procedure, in which the SIFT features are mapped from planning CT to CBCT and reversely. Only the associations common to both mappings are used in Thin Plate Spline (TPS) interpolation. A synthetic digital phantom experiment and five clinical head and neck cases are used to assess the performance of the proposed technique. Results: Image contents of the digital phantoms are modified in various ways. It is found the proposed technique can identify any of the changes faithfully. The subsequent feature-guided TPS interpolation reproduces the “ground truth” with an accuracy better than 1.3mm. For the clinical cases, the new algorithm works reliably for a volume change less than 30%, suggesting the time span between two consequent imaging sessions should not be unreasonably far away in order for the model to function properly. Conclusions: An image-based tumor kinetic model has been developed to better understand the tumor response to radiation therapy. The technique provides a solid foundation for future head-and-neck adaptive radiation therapy. No significant financial relationships to disclose.

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