Evaluation of Adaptive Radiation Therapy in Treatment of Locally Advanced Head and Neck cancers

2021 ◽  
Vol 2 (12) ◽  
pp. 51-58
Author(s):  
Mostafa Mostafa ◽  
Wael Elshishtawy ◽  
Ahmed Al-Agamawi
Keyword(s):  
Radiation Therapy ◽  
Head And Neck ◽  
Adaptive Radiation ◽  
Locally Advanced ◽  
Head And Neck Cancers ◽  
Advanced Head ◽  
Adaptive Radiation Therapy

scholarly journals Radiation therapy is well tolerated and produces excellent control rates in elderly patients with locally advanced head and neck cancers

2012 ◽  
Vol 3 (4) ◽  
pp. 337-343 ◽  
Author(s):  
Omar K. Jilani ◽  
Prabhsimranjot Singh ◽  
A. Gabriella Wernicke ◽  
David I. Kutler ◽  
William Kuhel ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Elderly Patients ◽  
Head And Neck ◽  
Locally Advanced ◽  
Head And Neck Cancers ◽  
Advanced Head ◽  
Excellent Control

Adaptive Radiation Therapy in Head and Neck Cancers: When Should we Re-plan?

2011 ◽  
Vol 81 (2) ◽  
pp. S494-S495
Author(s):  
F. Siddiqui ◽  
D. Boyle ◽  
M. Weldon ◽  
M. McGee ◽  
K. Kuhn ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Head And Neck ◽  
Adaptive Radiation ◽  
Head And Neck Cancers ◽  
Adaptive Radiation Therapy

Prospective analysis of qol in patients undergoing concurrent chemotherapy and radiation therapy for locally advanced head and neck cancer.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. e16058-e16058 ◽  
Author(s):  
Dukagjin Blakaj ◽  
Paola Godoy-Scripes ◽  
William Kempton Skinner ◽  
Shankar Viswanathan ◽  
Hilda Haynes ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Head And Neck ◽  
Locally Advanced ◽  
Concurrent Chemotherapy ◽  
Head And Neck Cancers ◽  
Matched Pair ◽  
Prospective Analysis ◽  
Advanced Head ◽  
Adaptive Planning ◽  
Dosimetric Data

e16058 Background: This is a prospective analysis of quality of life (QoL) in patients undergoing concurrent chemotherapy and IMRT for locally advanced head and neck cancers. Methods: In a prospective IRB approved study, patients undergoing concurrent chemotradio therapy for head and neck cancers at AECOM/MMC completed a QoL survey (EORTC QLQ-C30 and QLQ-H&N 35) pretreatment, during radiation therapy, and at 1, 3 and 6 months after completion. The patients were re-simulated for adaptive planning midway through their treatment. Patients were treated to 66-70Gy (2-2.12 Gy/Fraction) to the primary and 54 to 60Gy (1.64-1.8 Gy/fraction) to the subclinical and high risk areas. Swallowing complex (SC) (base of tongue, constrictor muscles, proximal esophagus and oral cavity) were contoured as avoidance structures along with other critical structures. QoL scores were correlated with radiation dose to swallowing complex to evaluate relationships. Results: The Global Heath Status and Physical Functioning scores fell (mean 58.33 SD 35.36) during the first week of therapy before recovering at the end of second week. There is a 2nd dip in functioning scores at 4th week subsequent to which the scores rise and stabilized. The nausea/vomiting scores correlate with the timing of chemotherapy whereas the pain scores are highest at the second week mark before declining gradually. The mean swallowing specific score is worst at 5 weeks (61.11 SD 31.43) and recover gradually thereafter to level better than pre-RT score at 6-months follow-up. Conclusions: Most studies have reported QoL changes before and after treatment and have not looked at the changes during RT. One would imagine that QoL scores would gradually deteriorate throughout radiation therapy and should be the worst towards the end. In our experience, most of the QoL scores stabilize during the latter half of radiation therapy. This may be a result of multidisciplinary patient care, adaptive radiation therapy as well as tumor response to chemo-radiation therapy. Matched pair analysis is underway to compare dosimetric data and correlate this with QoL results.

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