Potent orally bioavailable purine nucleoside phosphorylase inhibitor BCX-4208 induces apoptosis in B- and T-lymphocytes—A novel treatment approach for autoimmune diseases, organ transplantation and hematologic malignancies

Abstract Background Autoimmunity is used to cause by impairment of adaptive immunity alone, whereas autoinflammatory was originally defined as a consequence of unregulated innate immunity. So, the pathogenetic mechanisms of autoimmune diseases were well-thought-out to be mediated by B and T lymphocytes. Whereas, autoinflammatory diseases were defined as unprovoked times of inflammation with the absence of a high titre of autoantibodies. Main body of the abstract Autoimmune and autoinflammatory diseases were split into two groups, but considering the similarities, it can be considered as only one group of diseases with a large immune pathological and clinical spectrum which involves at one end pure autoimmune diseases and the other pure autoinflammatory diseases. Conclusions We can safely conclude that there is bridging between autoinflammatory and autoimmune diseases.

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Chemokines Determine Local Lymphoneogenesis and a Reduction of Circulating CXCR4+ T and CCR7 B and T Lymphocytes in Thyroid Autoimmune Diseases

The Journal of Immunology ◽

10.4049/jimmunol.170.12.6320 ◽

2003 ◽

Vol 170 (12) ◽

pp. 6320-6328 ◽

Cited By ~ 66

Author(s):

Maria-Pilar Armengol ◽

Cristina B. Cardoso-Schmidt ◽

Marco Fernández ◽

Xavier Ferrer ◽

Ricardo Pujol-Borrell ◽

...

Keyword(s):

T Lymphocytes ◽

Autoimmune Diseases ◽

B And T Lymphocytes

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Immunology Behind Tumors: A Mini Review

Current Cancer Therapy Reviews ◽

10.2174/1573394714666180907143433 ◽

2019 ◽

Vol 15 (3) ◽

pp. 174-183

Author(s):

Pooja Hurkat ◽

Sourabh Jain ◽

Richa Jain ◽

Aakanchha Jain

Keyword(s):

Immune System ◽

Tumor Microenvironment ◽

T Lymphocytes ◽

Immune Responses ◽

Autoimmune Diseases ◽

The Body ◽

Immune Checkpoints ◽

Genetic Constitution ◽

Great Care ◽

B And T Lymphocytes

Background:: The immune system is designed with great care to distinguish self from non-self, as exhibited by immune responses to different pathogens. Furthermore, the immune system has the capacity to distinguish between self from altered self in case of autoimmune diseases like cancer. Developing tumors bypass the immune system mechanism which restrains selfreactive responses. Immunotherapy is a coherent means since the immune system can eliminate a number of antigens derived from the genetic constitution of B and T lymphocytes. Our understanding of the immune system has developed a great deal. Conclusion:: This review is focused not only on the mechanism by which the immune system protects us but also on the ways in which it can inflict the body and how to modulate it with therapy. Thus, understanding the interaction of a tumor with the immune system provides insights into mechanisms that can be utilized to elicit anti-tumor immune responses. Here, we have recapitulated the function of the tumor microenvironment and immune checkpoints.

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