scholarly journals A photoswitchable helical peptide with light-controllable interface / transmembrane topology in lipidic membranes

iScience ◽  
2021 ◽  
pp. 102771
Author(s):  
Mónica Gutiérrez-Salazar ◽  
Eduardo Santamaría-Aranda ◽  
Louise Schaar ◽  
Jesús Salgado ◽  
Diego Sampedro ◽  
...  
Keyword(s):  
Transmembrane Topology ◽  
Helical Peptide

scholarly journals Effects of increasing hydrophobicity on the physical-chemical and biological properties of a class A amphipathic helical peptide

2001 ◽  
Vol 42 (7) ◽  
pp. 1096-1104 ◽  
Author(s):  
Geeta Datta ◽  
Manjula Chaddha ◽  
Susan Hama ◽  
Mohamad Navab ◽  
Alan M. Fogelman ◽  
...  
Keyword(s):  
Biological Properties ◽  
Class A ◽  
Physical Chemical ◽  
Helical Peptide

scholarly journals Rational design of novel amphipathic antimicrobial peptides focused on the distribution of cationic amino acid residues

MedChemComm ◽  
2019 ◽  
Vol 10 (6) ◽  
pp. 896-900 ◽  
Author(s):  
Takashi Misawa ◽  
Chihiro Goto ◽  
Norihito Shibata ◽  
Motoharu Hirano ◽  
Yutaka Kikuchi ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Amino Acid ◽  
Human Cell ◽  
Hemolytic Activity ◽  
Rational Design ◽  
Cell Cytotoxicity ◽  
Amino Acid Residues ◽  
High Antimicrobial Activity ◽  
Cationic Amino Acid ◽  
Helical Peptide

Amphipathic helical peptideStripeshowed high antimicrobial activity, low hemolytic activity, and low human cell cytotoxicity.

Carbohydrate-Dependent Hemolytic Activity of the Conjugate Composed of a C-Type Lectin, CEL-I, and an Amphiphilic α-Helical Peptide, 43-βAla2

1999 ◽  
Vol 63 (7) ◽  
pp. 1312-1314 ◽  
Author(s):  
Tomomitsu HATAKEYAMA ◽  
Tetsuji KAMINE ◽  
Yuko KONISHI ◽  
Hiromiki KUWAHARA ◽  
Takuro NIIDOME ◽  
...  
Keyword(s):  
Hemolytic Activity ◽  
Helical Peptide ◽  
Cel I

Single Vesicle Analysis Reveals Nanoscale Membrane Curvature Selective Pore Formation in Lipid Membranes by an Antiviral α-Helical Peptide

Nano Letters ◽  
2012 ◽  
Vol 12 (11) ◽  
pp. 5719-5725 ◽  
Author(s):  
Seyed R. Tabaei ◽  
Michael Rabe ◽  
Vladimir P. Zhdanov ◽  
Nam-Joon Cho ◽  
Fredrik Höök
Keyword(s):  
Lipid Membranes ◽  
Pore Formation ◽  
Membrane Curvature ◽  
Helical Peptide ◽  
Single Vesicle

scholarly journals Transmembrane topology of the glutamate receptor subunit GluR6.

1994 ◽  
Vol 269 (16) ◽  
pp. 11679-11682
Author(s):  
K.W. Roche ◽  
L.A. Raymond ◽  
C. Blackstone ◽  
R.L. Huganir
Keyword(s):  
Glutamate Receptor ◽  
Receptor Subunit ◽  
Transmembrane Topology ◽  
Glutamate Receptor Subunit

scholarly journals Exploring the in meso crystallization mechanism by characterizing the lipid mesophase microenvironment during the growth of single transmembrane α-helical peptide crystals

2016 ◽  
Vol 374 (2072) ◽  
pp. 20150125 ◽  
Author(s):  
Leonie van 't Hag ◽  
Konstantin Knoblich ◽  
Shane A. Seabrook ◽  
Nigel M. Kirby ◽  
Stephen T. Mudie ◽  
...  
Keyword(s):  
Crystal Growth ◽  
Self Assembly ◽  
Lamellar Phase ◽  
Cubic Phase ◽  
Supporting Evidence ◽  
X Ray ◽  
X Ray Scattering ◽  
Standard Procedures ◽  
Helical Peptide ◽  
Saxs Analysis

The proposed mechanism for in meso crystallization of transmembrane proteins suggests that a protein or peptide is initially uniformly dispersed in the lipid self-assembly cubic phase but that crystals grow from a local lamellar phase, which acts as a conduit between the crystal and the bulk cubic phase. However, there is very limited experimental evidence for this theory. We have developed protocols to investigate the lipid mesophase microenvironment during crystal growth using standard procedures readily available in crystallography laboratories. This technique was used to characterize the microenvironment during crystal growth of the DAP12-TM peptide using synchrotron small angle X-ray scattering (SAXS) with a micro-sized X-ray beam. Crystal growth was found to occur from the gyroid cubic mesophase. For one in four crystals, a highly oriented local lamellar phase was observed, providing supporting evidence for the proposed mechanism for in meso crystallization. A new observation of this study was that we can differentiate diffraction peaks from crystals grown in meso , from peaks originating from the surrounding lipid matrix, potentially opening up the possibility of high-throughput SAXS analysis of in meso grown crystals. This article is part of the themed issue ‘Soft interfacial materials: from fundamentals to formulation’.

The Enhancing Effect of Anionic α-Helical Peptide on Cationic Peptide-Mediating Transfection Systems

1997 ◽  
Vol 235 (3) ◽  
pp. 726-729 ◽  
Author(s):  
Naoya Ohmori ◽  
Takuro Niidome ◽  
Akihiro Wada ◽  
Toshiya Hirayama ◽  
Tomomitsu Hatakeyama ◽  
...  
Keyword(s):  
Cationic Peptide ◽  
Enhancing Effect ◽  
Helical Peptide
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