In this study, RC frames with unreinforced masonry (URM) infill for typical school buildings in Korea are experimentally investigated to evaluate their seismic performance. For this purpose, one-bay, one-fourth scale specimens, with unreinforced concrete block (CB) infill having different boundary conditions due to beam rigidity, are tested under in-plane cyclic loading, using a distinctive measurement scheme consisting of three-axis strain gauges attached to all CB units. In this paper, the diagonal strut mechanism of CB infill including its main strut angle, average compressive strain, and equivalent strut width is discussed using principal compressive strains on CB units. The lateral strength carried by CB infill and RC frame from the overall response of the specimens is also explained, based on the compressive stress acting on the infill and the curvature distribution along RC members during the test.