This study characterizes the climate structure in the Eastern United States for suitability of winegrape growth. For this study, the Eastern US is defined as the 44 contiguous Eastern most states. This excludes the premium wine growing states of California, Washington, Oregon and Idaho. For this characterization, a comparative study is performed on the four commonly used climate-viticulture indices (i.e., Average Growing Season Temperature, Growing Degree Days, Heliothermal Index and Biologically Effective Degree Days), and a new climate-viticulture index, the Modified-GSTavg (Mod-GSTavg). This is accomplished using the 1971 – 2000 PRISM 800-meter resolution dataset of climate temperature normal for the study area of 44 states and 62 American Viticultural Areas across the Eastern United States. The results revealed that all the climate indices have similar spatial patterns throughout the US with varying magnitudes and degrees of suitability.