Efficacy of Transcranial Near-Infrared Light Treatment in ASD: Update on Open-Label Proof of Concept Study of a Novel Approach

2019 ◽  
Vol 58 (10) ◽  
pp. S296-S297
Author(s):  
Tolga Atilla Ceranoglu
2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Cassandra Peoples ◽  
Victoria E. Shaw ◽  
Jonathan Stone ◽  
Glen Jeffery ◽  
Gary E. Baker ◽  
...  

We examined whether near-infrared light (NIr) treatment (photobiomodulation) saves dopaminergic amacrine cells of the retina in an acute and a chronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson disease. For the acute model, BALB/c mice had MPTP (100 mg/kg) or saline injections over 30 hours, followed by a six-day-survival period. For the chronic model, mice had MPTP (200 mg/kg) or saline injections over five weeks, followed by a three-week-survival period. NIr treatment was applied either at the same time (simultaneous series) or well after (posttreatment series) the MPTP insult. There were four groups within each series: Saline, Saline-NIr, MPTP, and MPTP-NIr. Retinae were processed for tyrosine hydroxylase (TH) immunochemistry, and cell number was analysed. In the MPTP groups, there was a significant reduction in TH+ cell number compared to the saline controls; this reduction was greater in the acute (~50%) compared to the chronic (~30%) cases. In the MPTP-NIr groups, there were significantly more TH+ cells than in the MPTP groups of both series (~30%). In summary, we showed that NIr treatment was able to both protect (simultaneous series) and rescue (posttreatment series) TH+ cells of the retina from parkinsonian insult.


2016 ◽  
Vol 234 (11) ◽  
pp. 3225-3232 ◽  
Author(s):  
Nabil El Massri ◽  
Cécile Moro ◽  
Napoleon Torres ◽  
Fannie Darlot ◽  
Diane Agay ◽  
...  

2018 ◽  
Vol 56 (5) ◽  
pp. 3341-3355 ◽  
Author(s):  
Michele M. Comerota ◽  
Batbayar Tumurbaatar ◽  
Balaji Krishnan ◽  
Rakez Kayed ◽  
Giulio Taglialatela

2013 ◽  
Vol 62 ◽  
pp. 36-42 ◽  
Author(s):  
Nicole L. Lohr ◽  
James T. Ninomiya ◽  
David C. Warltier ◽  
Dorothée Weihrauch

2010 ◽  
Vol 518 (1) ◽  
pp. 25-40 ◽  
Author(s):  
Victoria E. Shaw ◽  
Sharon Spana ◽  
Keyoumars Ashkan ◽  
Alim-Louis Benabid ◽  
Jonathan Stone ◽  
...  

2020 ◽  
Vol 59 (11) ◽  
pp. 110906
Author(s):  
Juan Shen ◽  
Yong Ren ◽  
Xinxin Zhu ◽  
Min Mao ◽  
Quan Zhou ◽  
...  

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