Necrolytic acral erythema associated with hepatitis C and serum zinc deficiency

2009 ◽  
Vol 60 (3) ◽  
pp. AB52
Keyword(s):  
Hepatitis C ◽  
Zinc Deficiency ◽  
Serum Zinc ◽  
Acral Erythema ◽  
Necrolytic Acral Erythema

scholarly journals Factors Attenuating Zinc Deficiency Improvement in Direct-Acting Antiviral Agent-Treated Chronic Hepatitis C Virus Infection

Nutrients ◽  
2018 ◽  
Vol 10 (11) ◽  
pp. 1620 ◽  
Author(s):  
Yi-Ling Ko ◽  
Daisuke Morihara ◽  
Kumiko Shibata ◽  
Ryo Yamauchi ◽  
Hiromi Fukuda ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Zinc Deficiency ◽  
Dietary Habits ◽  
Serum Zinc ◽  
Antiviral Agent ◽  
Zinc Status ◽  
Direct Acting Antiviral ◽  
Direct Acting

Zinc deficiency is frequently observed in chronic liver diseases. However, no studies have focused on the zinc status in chronic hepatitis C (HCV)-infected patients receiving direct-acting antiviral agents (DAAs). In this retrospective study, we assessed the serum zinc status in DAA-treated HCV patients with sustained virologic response for over two years (Zn-2y). Ninety-five patients were enrolled, whose baseline characteristics and blood parameters at DAA therapy initiation were collected. Baseline Zn < 65 µg/dL (odds ratio (OR) = 10.56, p < 0.001) and baseline uric acid (UA) > 5.5 mg/dL (OR = 9.99, p = 0.001) were independent risk factors for Zn-2y deficiency. A decision-tree algorithm classified low-baseline Zn and high-baseline UA as the first two variables, suggesting that baseline hypozincemia and hyperuricemia are prognosticators for long-term zinc deficiency. Baseline Zn was negatively correlated with the Fibrosis-4 (FIB-4) index, while baseline UA was significantly higher in habitual alcohol drinkers. In conclusion, serum zinc levels should be closely monitored, considering that zinc status improvement is related to liver fibrosis regression. Hyperuricemia indicates risks of developing metabolic disorders and subsequent zinc deficiency, for which an adjustment of personal lifestyle or dietary habits should be recommended clinically.

Necrolytic acral erythema: A cutaneous sign of hepatitis C virus infection

2005 ◽  
Vol 53 (2) ◽  
pp. 247-251 ◽  
Author(s):  
Mahmoud A. Abdallah ◽  
Mohamed Y. Ghozzi ◽  
Hoda A. Monib ◽  
Aisha M. Hafez ◽  
Kim M. Hiatt ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Hepatitis C Virus Infection ◽  
Acral Erythema ◽  
Necrolytic Acral Erythema

scholarly journals Bilateral Foot Skin Eruption in a Hepatitis C Patient

2020 ◽  
Vol 4 (3) ◽  
pp. 491-492
Author(s):  
Shane Davis ◽  
Angela Creditt
Keyword(s):  
Emergency Department ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Skin Eruption ◽  
Zinc Supplementation ◽  
Case Presentation ◽  
Acral Erythema ◽  
History Of ◽  
Necrolytic Acral Erythema ◽  
One Year

Case Presentation: A 58-year-old female with history of hepatitis C virus presented to the emergency department with a bilateral skin eruption to her feet for one year. Following skin biopsy, the patient was diagnosed with Necrolytic acral erythema (NAE). She was treated with clobetasol ointment, zinc supplementation, and mupirocin, which resulted in improvement in her symptoms. Discussion: NAE is a rash described as sharply demarcated, lichenified plaques on the dorsal foot and is a rare extra-hepatic manifestation of hepatitis C. This case details a patient with a skin eruption consistent with NAE.

scholarly journals Elevated Glucagon in a Patient with Necrolytic Acral Erythema: A Case Report and Review of the Literature

2021 ◽  
pp. 47-56
Author(s):  
Jenna E Koblinski ◽  
Blake W Traube ◽  
Margaret Kessler ◽  
Brenda Shinar
Keyword(s):  
Case Report ◽  
Elevated Serum ◽  
Serum Zinc ◽  
Review Of The Literature ◽  
Hcv Treatment ◽  
Acral Erythema ◽  
Necrolytic Migratory Erythema ◽  
Necrolytic Acral Erythema ◽  
Dermatologic Disease ◽  
Low Serum

Necrolytic acral erythema (NAE) is a relatively newly described dermatologic disease that is often associated with hepatitis C virus (HCV). Oral zinc therapy is a successful treatment; however, therapy is often delayed due to misdiagnosis. There are limited reports of NAE in the literature. This paper presents a case of NAE in a 68-year-old male with untreated HCV, whose NAE was diagnosed and treated as recurrent cellulitis for 12 years. He had low serum zinc and elevated serum glucagon levels. Elevated glucagon is not often reported in NAE, but the patient’s CT abdomen was negative, ruling out glucagonoma and necrolytic migratory erythema. He improved with oral zinc replacement and was referred to the hepatology department for HCV treatment. This paper additionally presents a review of the literature for NAE cases.

Necrolytic Acral Erythema as a Cutaneous Marker of Hepatitis C: Report of Two Cases and Review

2010 ◽  
Vol 55 (10) ◽  
pp. 2735-2743 ◽  
Author(s):  
James H. Tabibian ◽  
Meg R. Gerstenblith ◽  
Ryan J. Tedford ◽  
Jacqueline M. Junkins-Hopkins ◽  
Rachel Abuav
Keyword(s):  
Hepatitis C ◽  
Acral Erythema ◽  
Necrolytic Acral Erythema

scholarly journals Necrolytic Acral Erythema Associated With Hepatitis C

2000 ◽  
Vol 136 (6) ◽  
Author(s):  
Vikram J. Khanna ◽  
Sherry Shieh ◽  
Jaye Benjamin ◽  
Stephen Somach ◽  
M. Tarif Zaim ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Acral Erythema ◽  
Necrolytic Acral Erythema

scholarly journals Low prevalence of necrolytic acral erythema in patients with chronic hepatitis C virus infection

2012 ◽  
Vol 67 (5) ◽  
pp. 962-968 ◽  
Author(s):  
Brian A. Raphael ◽  
Zachariah L. Dorey-Stein ◽  
Jason Lott ◽  
Valerianna Amorosa ◽  
Vincent Lo Re ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Chronic Hepatitis C ◽  
Hepatitis C Virus Infection ◽  
Acral Erythema ◽  
Chronic Hepatitis C Virus ◽  
Necrolytic Acral Erythema ◽  
Low Prevalence
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