scholarly journals Elevated Glucagon in a Patient with Necrolytic Acral Erythema: A Case Report and Review of the Literature

2021 ◽  
pp. 47-56
Author(s):  
Jenna E Koblinski ◽  
Blake W Traube ◽  
Margaret Kessler ◽  
Brenda Shinar
Keyword(s):  
Case Report ◽  
Elevated Serum ◽  
Serum Zinc ◽  
Review Of The Literature ◽  
Hcv Treatment ◽  
Acral Erythema ◽  
Necrolytic Migratory Erythema ◽  
Necrolytic Acral Erythema ◽  
Dermatologic Disease ◽  
Low Serum

Necrolytic acral erythema (NAE) is a relatively newly described dermatologic disease that is often associated with hepatitis C virus (HCV). Oral zinc therapy is a successful treatment; however, therapy is often delayed due to misdiagnosis. There are limited reports of NAE in the literature. This paper presents a case of NAE in a 68-year-old male with untreated HCV, whose NAE was diagnosed and treated as recurrent cellulitis for 12 years. He had low serum zinc and elevated serum glucagon levels. Elevated glucagon is not often reported in NAE, but the patient’s CT abdomen was negative, ruling out glucagonoma and necrolytic migratory erythema. He improved with oral zinc replacement and was referred to the hepatology department for HCV treatment. This paper additionally presents a review of the literature for NAE cases.

Necrolytic acral erythema: a variant of necrolytic migratory erythema or a distinct entity?

2005 ◽  
Vol 44 (11) ◽  
pp. 916-921 ◽  
Author(s):  
Ahmad Abdelgawad Nofal ◽  
Eman Nofal ◽  
Enayat Attwa ◽  
Ola El-Assar ◽  
Magda Assaf
Keyword(s):  
Distinct Entity ◽  
Acral Erythema ◽  
Necrolytic Migratory Erythema ◽  
Necrolytic Acral Erythema

scholarly journals Coexistence of benign struma ovarii, pseudo-Meigs’ syndrome and elevated serum CA 125: Case report and review of the literature

2015 ◽  
Vol 9 (4) ◽  
pp. 1739-1742 ◽  
Author(s):  
CHENGJUAN JIN ◽  
RUIYING DONG ◽  
HUALEI BU ◽  
MINGYUAN YUAN ◽  
YOUZHONG ZHANG ◽  
...  
Keyword(s):  
Case Report ◽  
Elevated Serum ◽  
Ca 125 ◽  
Struma Ovarii ◽  
Review Of The Literature

Uterus-Like Ovarian Mass with Elevated Serum Levels of CA 19-9 and CA 125: A Case Report and Review of the Literature

2010 ◽  
Vol 30 (5) ◽  
pp. 1732-1736
Author(s):  
Canan KELTEN ◽  
Nagihan YALÇIN ◽  
Şermin ÇOBAN ◽  
Erkan ALATAŞ ◽  
Metin AKBULUT
Keyword(s):  
Case Report ◽  
Elevated Serum ◽  
Serum Levels ◽  
Ca 125 ◽  
Ovarian Mass ◽  
Review Of The Literature

scholarly journals Struma ovarii associated with pseudo-Meigs' syndrome and elevated serum CA 125: a case report and review of the literature

2010 ◽  
Vol 3 (1) ◽  
pp. 18 ◽  
Author(s):  
Wei Jiang ◽  
Xin Lu ◽  
Zhi Ling Zhu ◽  
Xi Shi Liu ◽  
Cong Jian Xu
Keyword(s):  
Case Report ◽  
Elevated Serum ◽  
Ca 125 ◽  
Struma Ovarii ◽  
Review Of The Literature

scholarly journals The glucagonoma syndrome and necrolytic migratory erythema: a clinical review

2004 ◽  
pp. 531-537 ◽  
Author(s):  
AP van Beek ◽  
ER de Haas ◽  
WA van Vloten ◽  
CJ Lips ◽  
JF Roijers ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin B ◽  
Presenting Symptoms ◽  
Acral Erythema ◽  
Necrolytic Migratory Erythema ◽  
Essential Nutrient ◽  
Skin Biopsies ◽  
Necrolytic Acral Erythema ◽  
Glycogen Stores ◽  
Typical Skin

The glucagonoma syndrome is a rare disease in which a typical skin disorder, necrolytic migratory erythema, is often one of the first presenting symptoms. Weight loss and diabetes mellitus are two other prevalent characteristics of this syndrome. Necrolytic migratory erythema belongs to the recently recognized family of deficiency dermatoses of which zinc deficiency, necrolytic acral erythema and pellagra are also members. It is typically characterized on skin biopsies by necrolysis of the upper epidermis with vacuolated keratinocytes. In persistent hyperglucagonemia, excessive stimulation of basic metabolic pathways results in diabetes mellitus at the expense of tissue glycogen stores, and muscle and fat mass. Multiple (essential) nutrient and vitamin B deficiencies develop, which contribute to the dermatosis. In addition, glucagonomas may produce various other products, like pancreatic polypeptide, that add to the catabolic effects of glucagon.

scholarly journals Necrolytic Acral Erythema

2017 ◽  
Vol 2 (1) ◽  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Histopathological Examination ◽  
Inflammatory Cells ◽  
Hepatitis C Virus Infection ◽  
Hepatitis C Infection ◽  
Acral Erythema ◽  
Necrolytic Migratory Erythema ◽  
Necrolytic Acral Erythema

Background: Necrolytic acral erythema (NAE) is a rare dermatosis which has been regarded as an early cutaneous marker of hepatitis C virus infection. The clinical manifestasion of NAE is similar to necrolytic migratory erythema, psoriasis and tinea corporis. The difference is that the patients with NAE also suffer from hepatitis C virus infection. Case: A 59 year old woman came and complained about itchy erythematous-violaceous plaques since a year ago. The patient has a history of hepatitis C infection since 2 years ago. On the superior and inferior extremities region, there were erythematous-violaceous plaques witch is partially hyperpigmentation with well-demarcated border, multiple discretes with thin scales and lichenification. Histopathological examination of the lesion obtained psoriasiform, hyperkeratosis, neutophylic microabscess, epidermal necrosis, spongiosis and infiltration of inflammatory cells in the epidermis. Discussion: Necrolytic acral erythema has been reported exclusively in patients with hepatitis C and is thought to be pathognomonic of this infection. Acute lesions often show erythema with vesicles and flaccid bullae. Chronic lesions appear as erythematous to violaceous plaques with thick scales, erosions and crust. Acral sites are predominantly involved. The histopathological examination shows psoriasiform hyperplasia epidermal, neutrophylic microabscesses, dilatation of small vessels, parakeratosis and infiltration of inflammatory cells. In this case, the physical and histopathological examination support the diagnosis of NAE.

scholarly journals Necrolytic acral erythema in a human immunodeficiency virus/hepatitis C virus coinfected patient: A case report

2019 ◽  
Vol 11 (2) ◽  
pp. 226-233 ◽  
Author(s):  
Katerina G Oikonomou ◽  
Dost Sarpel ◽  
Alexandra Abrams-Downey ◽  
Adnan Mubasher ◽  
Douglas T Dieterich
Keyword(s):  
Human Immunodeficiency Virus ◽  
Case Report ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Hepatitis ◽  
Acral Erythema ◽  
Immunodeficiency Virus ◽  
Coinfected Patient ◽  
Necrolytic Acral Erythema
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