scholarly journals Prognostic Value of Functional Performance for Mortality in Patients With Peripheral Artery Disease

2008 ◽  
Vol 51 (15) ◽  
pp. 1482-1489 ◽  
Author(s):  
Mary M. McDermott ◽  
Lu Tian ◽  
Kiang Liu ◽  
Jack M. Guralnik ◽  
Luigi Ferrucci ◽  
...  
Keyword(s):  
Peripheral Artery Disease ◽  
Prognostic Value ◽  
Functional Performance ◽  
Peripheral Artery ◽  
Artery Disease

Prognostic value of myeloperoxidase in patients with peripheral artery disease

Vascular ◽  
2020 ◽  
pp. 170853812095749
Author(s):  
Nadjib Schahab ◽  
Seyid Mansuroglu ◽  
Christian Schaefer ◽  
Rolf Fimmers ◽  
Georg Nickenig ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Vascular Disease ◽  
Peripheral Artery Disease ◽  
Prognostic Value ◽  
Target Lesion ◽  
Limb Ischaemia ◽  
Target Lesion Revascularisation ◽  
Peripheral Artery ◽  
Artery Disease

Objectives The involvement of myeloperoxidase in the production of dysfunctional high-density lipoproteins and oxidised biomolecules leads to oxidative stress in the blood vessel endothelium. This prospective cohort study aimed to examine the prognostic value of myeloperoxidase in patients with peripheral artery disease in relation to major adverse cardiac events (MACEs), target lesion revascularisation, and major adverse limb events (MALEs) and its association with multi-bed vascular disease, which is defined as any combination of the following: peripheral artery disease and coronary artery disease. Methods Myeloperoxidase levels were measured in patients with peripheral artery disease and coronary artery disease during angiography. A total of 94 patients were analysed and followed up regarding their MACEs, target lesion revascularisation, and MALEs from August 2016 until February 2019. Results Among patients with peripheral artery disease, the rates of MACE and mortality were higher in patients with high myeloperoxidase levels than in those with low myeloperoxidase levels; the myeloperoxidase levels were 3.68 times higher in these patients ( p < 0.0001). Patients with peripheral artery disease and coronary artery disease (multi-bed vascular disease) had higher myeloperoxidase levels than those with only peripheral artery disease and only coronary artery disease (one-bed vascular disease). Peripheral artery disease patients with higher myeloperoxidase levels had significantly higher rates of limb ischaemia, requiring further revascularisation than those with low myeloperoxidase levels. Conclusions High myeloperoxidase levels suggest poor outcomes and are associated with MACE and limb ischaemia. Our findings indicated that myeloperoxidase levels could become a prognostic marker and may be used in conjunction with other methods for risk stratification in patients with peripheral artery disease and multi-bed vascular disease.

scholarly journals Vitamin D status and functional performance in peripheral artery disease

2012 ◽  
Vol 17 (5) ◽  
pp. 294-302 ◽  
Author(s):  
Mary M McDermott ◽  
Kiang Liu ◽  
Luigi Ferrucci ◽  
Lu Tian ◽  
Jack Guralnik ◽  
...  
Keyword(s):  
Vitamin D ◽  
Peripheral Artery Disease ◽  
Functional Performance ◽  
Vitamin D Status ◽  
Peripheral Artery ◽  
Artery Disease

scholarly journals Progenitor cell release plus exercise to improve functional performance in peripheral artery disease: The PROPEL Study

2013 ◽  
Vol 36 (2) ◽  
pp. 502-509 ◽  
Author(s):  
Kathryn Domanchuk ◽  
Luigi Ferrucci ◽  
Jack M. Guralnik ◽  
Michael H. Criqui ◽  
Lu Tian ◽  
...  
Keyword(s):  
Peripheral Artery Disease ◽  
Progenitor Cell ◽  
Functional Performance ◽  
Peripheral Artery ◽  
Cell Release ◽  
Artery Disease

scholarly journals One‐Year Change in Walking Performance and Subsequent Mobility Loss and Mortality Rates in Peripheral Artery Disease: Longitudinal Data From the WALCS

2021 ◽  
Author(s):  
Michael M. Hammond ◽  
Lu Tian ◽  
Lihui Zhao ◽  
Dongxue Zhang ◽  
Mary M. McDermott
Keyword(s):  
Peripheral Artery Disease ◽  
Proportional Hazards ◽  
Functional Performance ◽  
Performance Measure ◽  
Cox Proportional Hazards ◽  
Peripheral Artery ◽  
Cox Proportional Hazards Models ◽  
Walking Velocity ◽  
Artery Disease ◽  
Minute Walk

Background Associations of 1‐year change in functional performance measures with subsequent mobility loss and mortality in people with lower extremity peripheral artery disease are unknown. Methods and Results Six‐minute walk and 4‐meter walking velocity (usual and fastest pace) were measured at baseline and 1 year later in 612 people with peripheral artery disease (mean age 71±9 years, 37% women). Participants were categorized into tertiles, based on 1‐year changes in walking measures. Cox proportional hazards models were used to examine associations between 1‐year change in each walking measure and subsequent mobility loss and mortality, respectively, adjusting for potential confounders. Compared with the best tertile, the worst tertile (ie, greatest decline) in 1‐year change in each performance measure was associated with higher rates of mobility loss: 6‐minute walk (Tertile 1 [T1] cumulative incidence rate [IR], 72/160; Tertile 3 [T3] IR, 47/160; hazard ratio [HR], 2.35; 95% CI, 1.47–3.74), usual‐paced 4‐meter walking velocity (T1 IR, 54/162; T3 IR, 57/162; HR, 2.21; 95% CI, 1.41–3.47), and fast‐paced 4‐meter walking velocity (T1 IR, 61/162; T3 IR, 58/162; HR, 1.81; 95% CI, 1.16–2.84). Compared with the best tertile, the worst tertiles in 1‐year change in 6‐minute walk (T1 IR, 66/163; T3 IR, 54/163; HR, 1.61; 95% CI, 1.07–2.43) and fast‐paced 4‐meter walking velocity (T1 IR, 63/166; T3 IR, 44/166; HR, 1.75; 95% CI, 1.16, 2.64) were associated with higher mortality. Conclusions In people with peripheral artery disease, greater 1‐year decline in 6‐minute walk or 4‐meter walking velocity may help identify people with peripheral artery disease at highest risk for mobility loss and mortality.

Different prognostic value of silent peripheral artery disease in type 2 diabetic and non-diabetic subjects with stable cardiovascular disease

2011 ◽  
Vol 214 (1) ◽  
pp. 191-195 ◽  
Author(s):  
Jose M. Mostaza ◽  
Luis Manzano ◽  
Carmen Suarez ◽  
Cristina Fernandez ◽  
Maria M. García de Enterría ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Peripheral Artery Disease ◽  
Prognostic Value ◽  
Peripheral Artery ◽  
Artery Disease ◽  
Type 2 Diabetic

Associations of coronary and peripheral artery disease with presence, expansion, and rupture of abdominal aortic aneurysm – a grin without a cat!

VASA ◽  
2017 ◽  
Vol 46 (3) ◽  
pp. 151-158 ◽  
Author(s):  
Hisato Takagi ◽  
Takuya Umemoto
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Peripheral Artery Disease ◽  
Literature Search ◽  
Systematic Literature Search ◽  
Peripheral Artery ◽  
Epidemiological Evidence ◽  
Abdominal Aortic ◽  
Artery Disease ◽  
Meta Analyses

Abstract. Both coronary and peripheral artery disease are representative atherosclerotic diseases, which are also known to be positively associated with presence of abdominal aortic aneurysm. It is still controversial, however, whether coronary and peripheral artery disease are positively associated with expansion and rupture as well as presence of abdominal aortic aneurysm. In the present article, we overviewed epidemiological evidence, i. e. meta-analyses, regarding the associations of coronary and peripheral artery disease with presence, expansion, and rupture of abdominal aortic aneurysm through a systematic literature search. Our exhaustive search identified seven meta-analyses, which suggest that both coronary and peripheral artery disease are positively associated with presence of abdominal aortic aneurysm, may be negatively associated with expansion of abdominal aortic aneurysm, and might be unassociated with rupture of abdominal aortic aneurysm.

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