scholarly journals TCT-368 Lower socioeconomic status predicts major adverse cardiac events (MACE) and increased mortality post-percutaneous intervention (PCI): Independent hazard vs. intersection of modifiable risk factors?

2012 ◽  
Vol 60 (17) ◽  
pp. B105-B106
Author(s):  
Ali Mithani ◽  
Steve Attanasio ◽  
Andew Appis ◽  
Emily Guhl ◽  
Tamar Polonsky ◽  
...  
Keyword(s):  
Risk Factors ◽  
Socioeconomic Status ◽  
Percutaneous Intervention ◽  
Major Adverse Cardiac Events ◽  
Modifiable Risk Factors ◽  
Cardiac Events ◽  
Lower Socioeconomic Status ◽  
Lower Socioeconomic ◽  
Adverse Cardiac Events

Impact of socioeconomic status on medication compliance and major adverse cardiac events following PCI

2009 ◽  
Vol 18 ◽  
pp. S265-S266
Author(s):  
Lisa Lefkovits ◽  
Nick Andrianopoulos ◽  
Dion Stub ◽  
David J. Clark ◽  
Andrew E. Ajani ◽  
...  
Keyword(s):  
Socioeconomic Status ◽  
Medication Compliance ◽  
Major Adverse Cardiac Events ◽  
Cardiac Events ◽  
Adverse Cardiac Events

Abstract 5510: Arginine Methylation Index as Integrated Quantification of Arginine Methylation Provides Stronger Independent Risk Prediction of Long-term Cardiovascular Events than Individual Methylated Arginine Metabolites

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
W. H. Wilson Tang ◽  
Zeneng Wang ◽  
Leslie Cho ◽  
Danielle M Brennan ◽  
Stanley L Hazen
Keyword(s):  
Risk Factors ◽  
Risk Prediction ◽  
Arginine Methylation ◽  
Major Adverse Cardiac Events ◽  
Post Translational Modification ◽  
Cardiac Events ◽  
Methylation Index ◽  
Diagnostic Cardiac Catheterization ◽  
Adverse Cardiac Events ◽  
Prognostic Utility

Background: The prognostic value of asymmetric dimethylarginine (ADMA) is attributed to its role as an endogenous inhibitor of nitric oxide synthases (NOS). The relationship of related post-translational modification products of arginine methylation and cardiovascular disease (CVD) risks is uncertain. Methods: Plasma was isolated from 1,011 subjects undergoing diagnostic cardiac catheterization, and future major adverse cardiac events (MACE, including myocardial infarction, stroke, and death) were investigated. Levels of ADMA, symmetric dimethylarginine (SDMA), and N-mono-methylarginine (MMA) were quantified by mass spectrometry, and their ratios [(ADMA+SDMA)/MMA], the arginine methylation index (Methy-I Arg ), were determined. Results: After adjusting for Framingham risk factors, CRP, and creatinine clearance, elevated (4th vs. 1st quartile) plasma levels of both SDMA [2.0-fold (95%CI, 1.3–3.1)] and ADMA [1.5-fold (95%CI, 1.00–2.4)] remained associated with higher prevalence of CVD, whereas elevated levels of MMA [0.56-fold (95%CI, 0.36–0.87)] were paradoxically associated with lower CVD. While elevated ADMA and SDMA levels remained significant predictors, MethyI Arg was the strongest independent predictor of incident MACE[2.4-fold (95%CI, 1.3 to 4.5)]. Conclusions: An integrated quantification of arginine methylation in the form of an “Arginine Methylation Index” provided the strongest independent risk prediction for incident major adverse cardiac events in stable patients undergoing elective cardiac evaluation, and significantly added to the prognostic utility of traditional risk factors.

scholarly journals Dental Treatment Needs and Related Risk Factors among School Children with Special Needs in Taiwan

2021 ◽  
Vol 11 (6) ◽  
pp. 452
Author(s):  
Szu-Yu Hsiao ◽  
Ping-Ho Chen ◽  
Shan-Shan Huang ◽  
Cheng-Wei Yen ◽  
Shun-Te Huang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Socioeconomic Status ◽  
Dental Caries ◽  
Dental Treatment ◽  
Significant Risk ◽  
World Health ◽  
Treatment Needs ◽  
Lower Socioeconomic Status ◽  
Lower Socioeconomic ◽  
Related Risk

The purpose of this study was to assess dental treatment needs (TNs) and related risk factors of children with disabilities (CD). This cross-sectional study recruited 484 CD, 6 to 12 years of age, from 10 special education schools in Taiwan. Dental status and TNs were examined and evaluated by well-trained dentists and based on the criteria set by the World Health Organization (1997). The results indicated that 61.78% required restorative dental treatment due to their dental caries. On average, each participant had 2.72 teeth that required treatment, and 6.38 surfaces required restoration. One-quarter of the participants (24.79%) required 1- or 2-surface restoration, and one out of three (36.98%) had more complex TNs (including 3 or more surfaces to be filled, pulp care, extraction, and more specialized care). The significant risk factors associated with restorative TNs among CD were those whose parents had lower socioeconomic status, frequent sweets intake, insufficient tooth-brushing ability, and poor oral health. Most of the CD had extensive unmet TNs for their caries and required complex treatment to recover the function of their teeth. Encouraging parents/caregivers to take their children for dental treatment, promoting awareness of the importance of dental hygiene, giving assistance to brushing their teeth after eating, and controlling and/or modifying sweet diet habits are necessary to reduce CD’s dental caries, especially those with lower socioeconomic status parents/caregivers.

scholarly journals Anesthesia-Related Airway Patient Safety Incidents Correlated with Major Adverse Cardiac Events: A Single-Center Retrospective Case-Control Analysis from 2009 to 2019

2021 ◽  
Author(s):  
Xue Zhang ◽  
Lingeer Wu ◽  
Huizhen Huang ◽  
Yuelun Zhang ◽  
Le Shen ◽  
...  
Keyword(s):  
Risk Factors ◽  
Patient Safety ◽  
Case Control ◽  
Mean Difference ◽  
Major Adverse Cardiac Events ◽  
Cardiac Events ◽  
Retrospective Case ◽  
Adverse Cardiac Events ◽  
Extubation Time ◽  
Patient Safety Incidents

Abstract Background: Airway-related patient safety incidents (PSIs) have always been the top concern of anesthesiologists because this type of incident could severely threaten patient safety if not treated immediately and properly. This study aimed to reveal the composition and outcomes of and to identify risk factors related to airway incidents reported by anesthesiologists.Methods: All airway-related PSIs reported by anesthesiologists at a Chinese academic hospital between September 2009 and August 2019 were collected from the PSI reporting system. Patients with reported airway incidents were matched 1:1 with controls based on sex and type of surgery. Univariate and multivariate analyses were performed to identify risk factors associated with airway incident occurrence and to evaluate the influence of airway PSIs on the prognosis.Results: Among 773 PSIs voluntarily reported by anesthesiologists during the study period, 208 (26.9%) were airway-related incidents, with an overall reporting incidence of 4.59 per 10,000. In patients with reported airway PSIs, postoperative major adverse cardiac events (MACEs) were more likely (7 vs 1 case, odds ratio: 7.37 [95% confidence interval (CI): 0.89 to 60.83], p=0.031) and the extubation time (0.82±1.63 d vs 0.21±0.89 d, mean difference: 0.61 d [95% CI: 0.28 to 0.95 d], p<0.001) and ICU length of stay (LOS) (2.03±6.66 d vs 0.22±0.96 d, mean difference 1.81 d [95% CI: 0.60 to 3.02 d], p=0.004) were longer. Only the American Society of Anesthesiologists (ASA) physical status was found to be a significant independent predictor of these airway PSIs.Conclusions: This single-institutional retrospective case-control study describes the composition of airway-related PSIs reported by anesthesiologists within eleven years. Airway incidents influence the prognosis by increasing the incidence of postoperative MACEs and prolonging both the extubation time and ICU LOS. Airway PSI data are worth analyzing to improve patient safety.

scholarly journals Increased Trimethylamine N-Oxide Portends High Mortality Risk Independent of Glycemic Control in Patients with Type 2 Diabetes Mellitus

2017 ◽  
Vol 63 (1) ◽  
pp. 297-306 ◽  
Author(s):  
W H Wilson Tang ◽  
Zeneng Wang ◽  
Xinmin S Li ◽  
Yiying Fan ◽  
Daniel S Li ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Glycemic Control ◽  
Major Adverse Cardiac Events ◽  
Cardiac Events ◽  
Mortality Risks ◽  
Adverse Cardiac Events ◽  
Gut Microbe ◽  
Traditional Risk Factors

Abstract BACKGROUND Recent studies show a mechanistic link between intestinal microbial metabolism of dietary phosphatidylcholine and coronary artery disease pathogenesis. Concentrations of a proatherogenic gut microbe-generated metabolite, trimethylamine N-oxide (TMAO), predict increased incident cardiovascular disease risks in multiple cohorts. TMAO concentrations are increased in patients with type 2 diabetes mellitus (T2DM), but their prognostic value and relation to glycemic control are unclear. METHODS We examined the relationship between fasting TMAO and 2 of its nutrient precursors, choline and betaine, vs 3-year major adverse cardiac events and 5-year mortality in 1216 stable patients with T2DM who underwent elective diagnostic coronary angiography. RESULTS TMAO [4.4 μmol/L (interquartile range 2.8–7.7 μmol/L) vs 3.6 (2.3–5.7 μmol/L); P &lt; 0.001] and choline concentrations were higher in individuals with T2DM vs healthy controls. Within T2DM patients, higher plasma TMAO was associated with a significant 3.0-fold increased 3-year major adverse cardiac event risk (P &lt; 0.001) and a 3.6-fold increased 5-year mortality risk (P &lt; 0.001). Following adjustments for traditional risk factors and high-sensitivity C-reactive protein, glycohemoglobin, and estimated glomerular filtration rate, increased TMAO concentrations remained predictive of both major adverse cardiac events and mortality risks in T2DM patients [e.g., quartiles 4 vs 1, hazard ratio 2.05 (95% CI, 1.31–3.20), P &lt; 0.001; and 2.07 (95% CI, 1.37–3.14), P &lt; 0.001, respectively]. CONCLUSIONS Fasting plasma concentrations of the proatherogenic gut microbe-generated metabolite TMAO are higher in diabetic patients and portend higher major adverse cardiac events and mortality risks independent of traditional risk factors, renal function, and relationship to glycemic control.

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