GW25-e3556 The analysis of the relationship between coronary artery stenosis and cerebral vascular stenosis

Abstract Background We investigated the role of ANGPTL3 and ANGPTL4 in atherosclerosis development and determined whether plasma concentrations of ANGPTL3 and ANGPTL4 are related to the degree of coronary stenosis. Methods A total of 305 consecutive patients with angina who underwent diagnostic coronary angiography were enrolled in the study between August 2017 and August 2018. The levels of ANGPTL3 and ANGPTL4 were measured by using competitive ELISA kits. Results According to the degree of coronary artery stenosis, patients were classified into four types: coronary artery stenosis of < 10%, 10-50%, 50-75, and > 75%. The plasma ANGPTL3 level was higher (51.71 ± 52.67 vs. 24.65 ± 10.32 ng/mL, P < 0.001) and that of ANGPTL4 was lower (454.66 ± 269.05 vs. 875.49 ± 961.15 ng/mL, P < 0.001) in the coronary artery stenosis ≥ 10% group than in the < 10% group. ANGPTL3 and ANGPTL4 levels were significantly associated with the severity of coronary vascular stenosis. ROC curve analyses indicated that ANGPTL3 concentrations above 30.5 ng/mL can predict atherosclerosis with a sensitivity of 71.2% and specificity of 75.3%, and that ANGPTL4 levels below 497.5 ng/mL can predict atherosclerosis with a sensitivity of 63.9% and specificity of 74.5%. ANGPTL3 and ANGPTL4 were determined to be independent risk factors for coronary atherosclerosis with odds ratios (ORs) of 0.189 (95% CI 0.097-0.368, P < 0.001) and 3.625 (95% CI 1.873-7.016, P < 0.001), respectively. Conclusions Increased ANGPTL3 or decreased ANGPTL4 shows an association with coronary atherosclerosis and, may become a predictor of coronary atherosclerosis in the future.

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The Relationship between Progression of Coronary Artery Stenosis and Serum Adiponectin, ICAM(Intercellular Adhesion Molecule)-1 Level

Korean Circulation Journal ◽

10.4070/kcj.2004.34.9.837 ◽

2004 ◽

Vol 34 (9) ◽

pp. 837 ◽

Cited By ~ 1

Author(s):

Hyoung Seob Park ◽

Kee Sik Kim ◽

Chang Wook Park ◽

Min Jung Kim ◽

Yun Kyeong Cho ◽

...

Keyword(s):

Coronary Artery ◽

Adhesion Molecule ◽

Coronary Artery Stenosis ◽

Intercellular Adhesion ◽

Artery Stenosis ◽

Serum Adiponectin ◽

Intercellular Adhesion Molecule ◽

Intercellular Adhesion Molecule 1 ◽

The Relationship

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Lack of Association between Interarm Systolic Blood Pressure Difference and Coronary Artery Disease in Patients Undergoing Elective Coronary Angiography

International Journal of Hypertension ◽

10.1155/2021/6665039 ◽

2021 ◽

Vol 2021 ◽

pp. 1-7

Author(s):

Mohammad Hosein Mohamadi ◽

Alireza Rai ◽

Mansour Rezaei ◽

Alireza Khatony

Keyword(s):

Blood Pressure ◽

Coronary Artery Disease ◽

Coronary Artery ◽

Coronary Angiography ◽

Coronary Artery Stenosis ◽

Artery Stenosis ◽

Peripheral Vascular ◽

Blood Pressure Difference ◽

Artery Disease ◽

The Relationship

Aim. Peripheral vascular disease (PVD) and coronary artery disease (CAD) are, in many cases, asymptomatic and not usually diagnosed. The timely diagnosis of peripheral vascular diseases can act as an indicator or practical evidence of CAD. Therefore, this study was conducted to determine the relationship between interarm systolic blood pressure difference (IASBPD) and severity and number of coronary artery stenosis. Methods. The samples in this cross-sectional study consisted of 578 patients who were candidates for coronary angiography, with an average age of 57.5 ± 10.5 years. Patients were classified according to CAD and number and severity of coronary artery stenosis. The relationship between IASBPD and presence or lack of CAD as well as the number and severity of coronary artery stenosis was studied. The sensitivity, specificity, and positive predictive value of IASBPD index were calculated for the detection of CAD using the Kappa coefficient. Results. There was no statistically significant relationship between IASBPD, CAD, and severity and number of coronary artery stenosis. This index had low sensitivity and predictive value in the diagnosis of CAD and stenosis in coronary arteries in comparison with angiography. Conclusion. The results showed that the IASBPD index cannot be a valid criterion for the diagnosis of CAD as well as the number and severity of coronary artery stenosis. More studies with larger sample sizes and different designs are needed in this regard to achieve more conclusive results.

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Levels of indoxyl sulfate are associated with severity of coronary atherosclerosis

Clinical & Investigative Medicine ◽

10.25011/cim.v36i1.19404 ◽

2013 ◽

Vol 36 (1) ◽

pp. 42 ◽

Cited By ~ 31

Author(s):

Chia-Chang Hsu ◽

Yung-Chuan Lu ◽

Cheng-An Chiu ◽

Teng-Hung Yu ◽

Wei-Chin Hung ◽

...

Keyword(s):

Coronary Artery ◽

Coronary Atherosclerosis ◽

Coronary Artery Stenosis ◽

Calcium Score ◽

Ultra Performance Liquid Chromatography ◽

Endothelial Damage ◽

Artery Stenosis ◽

Indoxyl Sulfate ◽

Artery Disease ◽

The Relationship

Purpose: Indoxyl sulfate (IS) is linked to endothelial damage, NF-κB activation and induced development of atherosclerosis. The purpose of this study was to investigate the relationship between serum IS levels and the severity of coronary artery stenosis. In addition, the relationship among IS and various cardiovascular risk factors was also explored. Methods: Serum IS concentrations were measured using ultra performance liquid chromatography in 191 consecutive patients presenting with stable angina. The associations between serum IS levels and angiographic indexes of the number of diseased vessels, modified Gensini scores and calcium scores were determined. Results: Patients with significant coronary artery stenosis were found to have higher serum IS levels than patients with normal coronary arteries. Using multivariate analysis, serum IS levels were found to be independently associated with the presence and severity of coronary artery disease (CAD). Furthermore, statistically significant correlation was observed between the serum IS levels and age, Agatston calcium score, volume calcium score, modified Gensini score, coronary lesions, coronary disease and Framingham-10 year risk score. Conclusion:This study indicates that serum IS levels are significantly higher in the presence of CAD and correlate with the severity of the disease and coronary atherosclerosis scores, which suggest that increased serum IS may be involved in the pathogenesis of coronary atherosclerosis.

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Influence of Coronary Artery Stenosis Severity and Coronary Collateralization on Extent of Chronic Myocardial Scar: Insights from Quantitative Coronary Angiography and Delayed-Enhancement MRI

The Open Cardiovascular Medicine Journal ◽

10.2174/1874192400802010079 ◽

2008 ◽

Vol 2 (1) ◽

pp. 79-86 ◽

Cited By ~ 9

Author(s):

Daniel Bexell ◽

Randolph M Setser ◽

Paul Schoenhagen ◽

Michael L Lieber ◽

Sorin J Brener ◽

...

Keyword(s):

Coronary Artery ◽

Coronary Angiography ◽

Coronary Artery Stenosis ◽

Quantitative Coronary Angiography ◽

Myocardial Scar ◽

Delayed Enhancement ◽

Artery Stenosis ◽

Significant Stenosis ◽

Stenosis Severity ◽

The Relationship

Objectives:In patients with chronic ischemic heart disease, the relationship between coronary artery lesion severity and myocardial scarring is unknown.The purpose of this study was to examine the relationship between proximal coronary artery stenosis severity, the amount of coronary collateralization, and myocardial scar extent in the distal distribution of the affected coronary artery based on both quantitative coronary angiography (QCA) and delayed-enhancement magnetic resonance imaging (DE–MRI).Methods:Thirty-four patients (26 males, 8 females; age range: 35-86 years) with a coronary artery containing a single, proximal stenosis ≥30% by quantitative coronary angiography (QCA) underwent DE-MRI. The relationship between stenosis severity, collateralization, and myocardial scar morphology (area, transmurality and patchiness) was examined using linear mixed-model ANCOVA.Results:There was a statistically significant correlation between stenosis severity and scar extent (r=0.53, p<0.01). Patients with hemodynamically significant stenoses (≥70%) exhibited significantly greater collateralization (p<0.05) and scar extent (p<0.01) than patients with <70% stenosis. However, scarring was often found in patients with stenoses <70%. Also, greater stenosis severity (93±14%) and mean scar extent (41±35%) were found in patients with collaterals than in patients without collaterals (diameter stenosis 48±10%, p<0.01) (scar extent 19±29%, p=0.01).Conclusions:Using QCA and DE-MRI, we demonstrate a significant relationship between coronary artery stenosis severity and myocardial scar extent, in the absence of a documented history of acute infarction. The relationship likely reflects increasing ischemia leading to scar formation in the range of angiographically significant stenosis. However, in the absence of collateralization, scar was observed without significant stenosis, especially in females.

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