TCT-50 Incidence and Prognostic Significance of Heart Failure Hospitalization After Transcatheter or Surgical Aortic Valve Replacement: Results From the PARTNER Trials

Left bundle branch block (LBBB) is not an uncommon complication following both surgical aortic valve replacement and transcatheter aortic valve implantation. LBBB can cause interventricular and intraventricular dyssynchrony that can lead to development of heart failure as demonstrated by a decline in left ventricular ejection fraction (LVEF). It is known that change in QRS duration has significant correlation with change in LVEF. In a study involving 202 consecutive patients with no baseline ventricular conduction disturbances or previous permanent pacemaker implantation who underwent transcatheter aortic valve replacement (TAVR) with a balloon-expandable valve, it was found that around 30% of patients develop new LBBB.

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Right ventricular function and outcome in patients undergoing transcatheter aortic valve replacement

European Heart Journal - Cardiovascular Imaging ◽

10.1093/ehjci/jeaa342 ◽

2020 ◽

Author(s):

Matthias Koschutnik ◽

Varius Dannenberg ◽

Christian Nitsche ◽

Carolina Donà ◽

Jolanta M Siller-Matula ◽

...

Keyword(s):

Heart Failure ◽

Aortic Valve ◽

Aortic Valve Replacement ◽

Right Ventricular ◽

Hospital Stay ◽

Valve Replacement ◽

Transcatheter Aortic Valve Replacement ◽

Heart Failure Hospitalization ◽

Transcatheter Aortic Valve ◽

Rv Function

Abstract Aims Right ventricular dysfunction (RVD) on echocardiography has been shown to predict outcomes in patients undergoing transcatheter aortic valve replacement (TAVR). However, a comparison with the gold standard, RV ejection fraction (EF) on cardiovascular magnetic resonance (CMR), has never been performed. Methods and results Consecutive patients scheduled for TAVR underwent echocardiography and CMR. RV fractional area change (FAC), tricuspid annular plane systolic excursion, RV free-lateral-wall tissue Doppler (S’), and strain were assessed on echocardiography, and RVEF on CMR. Patients were prospectively followed. Adjusted regression analyses were used to report the strength of association per 1-SD decline for each RV function parameter with (i) N-terminal prohormone of brain natriuretic peptide (NT-proBNP) levels, (ii) prolonged in-hospital stay (>14 days), and (iii) a composite of heart failure hospitalization and death. Two hundred and four patients (80.9 ± 6.6 y/o; 51% female; EuroSCORE-II: 6.3 ± 5.1%) were included. At a cross-sectional level, all RV function parameters were associated with NT-proBNP levels, but only FAC and RVEF were significantly associated with a prolonged in-hospital stay [adjusted odds ratio 1.86, 95% confidence interval (CI) 1.07–3.21; P = 0.027 and 2.29, 95% CI 1.43–3.67; P = 0.001, respectively]. A total of 56 events occurred during follow-up (mean 13.7 ± 9.5 months). After adjustment for the EuroSCORE-II, only RVEF was significantly associated with the composite endpoint (adjusted hazard ratio 1.70, 95% CI 1.32–2.20; P < 0.001). Conclusion RVD as defined by echocardiography is associated with an advanced disease state but fails to predict outcomes after adjustment for pre-existing clinical risk factors in TAVR patients. In contrast, RVEF on CMR is independently associated with heart failure hospitalization and death.

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