Relationship of Serum 25-hydroxyvitamin D Levels with the Severity of Atopic Dermatitis in Children

Abstract Context The relationship of maternal and infant 25-hydroxyvitamin D concentration [25(OH)D] with infant growth is unclear. Objective Our objective was to explore whether 25(OH)D in pregnancy, umbilical cord blood (UCB), or in infancy was associated with infant growth. Design This study involved 798 healthy infants and their mothers in Finland. We assessed 25(OH)D during pregnancy, from UCB at birth, and from the infant at the age of 12 months. Main Outcome Measures Infant length, weight, length-adjusted weight, and head circumference at 6 and 12 months and midupper-arm circumference at 12 months. Results Of the mothers and infants, 96% and 99% were vitamin D sufficient [25(OH)D ≥50 nmol/L], respectively. Mothers with pregnancy 25(OH)D >125 nmol/L had the shortest, lightest (in weight), and thinnest (in length-adjusted weight) infants at 6 months (P for all < 0.05). For each 10 nmol/L higher UCB 25(OH)D, the infants were 0.03 SD score (SDS) shorter at 6 months (95% CI −0.05 to −0.01), adjusted for birth size, infant 25(OH)D, and parental height. Higher UCB 25(OH)D associated with smaller head circumference at 6 and 12 months (P for all <0.05) but attenuated after adjustments. Mothers with pregnancy 25(OH)D >125 nmol/L had the thinnest infants at 12 months (P = 0.021). For each 10 nmol/L higher infant 25(OH)D, the infants were 0.03 SDS lighter (−0.05 to −0.01) and 0.03 SDS thinner (−0.05 to 0.00) at 12 months. Conclusions Our results suggest that high pregnancy, cord blood, and infant vitamin D concentration may have disadvantageous effects on infant growth.

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Correlation Between Serum 25-Hydroxyvitamin D and Virulence Genes ofStaphylococcus aureusIsolates Colonizing Children with Atopic Dermatitis

Pediatric Dermatology ◽

10.1111/pde.12436 ◽

2014 ◽

Vol 32 (4) ◽

pp. 506-513 ◽

Cited By ~ 13

Author(s):

Yolanda Gilaberte ◽

Rosalía Sanmartín ◽

Carmen Aspiroz ◽

Angela Hernandez-Martin ◽

Daniel Benito ◽

...

Keyword(s):

Atopic Dermatitis ◽

Virulence Genes ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D

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Associations of Sun Exposure with 25-Hydroxyvitamin D and Parathyroid Hormone Levels in a Cohort of Hypertensive Patients: The Graz Endocrine Causes of Hypertension (GECOH) Study

International Journal of Endocrinology ◽

10.1155/2012/732636 ◽

2012 ◽

Vol 2012 ◽

pp. 1-8 ◽

Cited By ~ 2

Author(s):

Stefan Pilz ◽

Katharina Kienreich ◽

Daniel Stückler ◽

Andreas Meinitzer ◽

Andreas Tomaschitz

Keyword(s):

Vitamin D ◽

Parathyroid Hormone ◽

Scalp Hair ◽

Sun Exposure ◽

Hypertensive Patients ◽

Hydroxyvitamin D ◽

Outdoor Sports ◽

25 Hydroxyvitamin D ◽

Relationship Of ◽

The Relationship

Sunlight-induced vitamin D, synthesis in the skin is the major source of vitamin D, but data on the relationship of sun-related behaviour with vitamin D and parathyroid hormone (PTH) levels are relatively sparse. We evaluated whether habitual sun exposure is associated with 25-hydroxyvitamin D (25[OH]D) and PTH levels and whether there exist seasonal variations. We examined 111 hypertensive patients in Austria (latitude 47° N). Frequent sunbathing at home and outdoor sports were associated with higher 25(OH)D levels (P<0.05for both). Red or blond scalp hair as a child, memory of sunburns, preferring sunbathing, frequent stays on the beach or in open-air pools, and solarium use were associated with lower PTH levels (P<0.05for all). Multiple linear regression analyses including age, sex, and body mass index showed that sun exposure score was significantly associated with 25(OH)D (betacoefficient=0.27;P=0.004) and by trend with PTH (betacoefficient=−0.16;P=0.09). These associations were more prominent in summer in which 25(OH)D levels were significantly higher compared to winter. Translation of these findings into recommendations for the prevention and treatment of vitamin D deficiency remains a challenge for the future.

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