High Pregnancy, Cord Blood, and Infant Vitamin D Concentrations May Predict Slower Infant Growth

Abstract Context The relationship of maternal and infant 25-hydroxyvitamin D concentration [25(OH)D] with infant growth is unclear. Objective Our objective was to explore whether 25(OH)D in pregnancy, umbilical cord blood (UCB), or in infancy was associated with infant growth. Design This study involved 798 healthy infants and their mothers in Finland. We assessed 25(OH)D during pregnancy, from UCB at birth, and from the infant at the age of 12 months. Main Outcome Measures Infant length, weight, length-adjusted weight, and head circumference at 6 and 12 months and midupper-arm circumference at 12 months. Results Of the mothers and infants, 96% and 99% were vitamin D sufficient [25(OH)D ≥50 nmol/L], respectively. Mothers with pregnancy 25(OH)D >125 nmol/L had the shortest, lightest (in weight), and thinnest (in length-adjusted weight) infants at 6 months (P for all < 0.05). For each 10 nmol/L higher UCB 25(OH)D, the infants were 0.03 SD score (SDS) shorter at 6 months (95% CI −0.05 to −0.01), adjusted for birth size, infant 25(OH)D, and parental height. Higher UCB 25(OH)D associated with smaller head circumference at 6 and 12 months (P for all <0.05) but attenuated after adjustments. Mothers with pregnancy 25(OH)D >125 nmol/L had the thinnest infants at 12 months (P = 0.021). For each 10 nmol/L higher infant 25(OH)D, the infants were 0.03 SDS lighter (−0.05 to −0.01) and 0.03 SDS thinner (−0.05 to 0.00) at 12 months. Conclusions Our results suggest that high pregnancy, cord blood, and infant vitamin D concentration may have disadvantageous effects on infant growth.

Download Full-text

Expression network analysis reveals cord blood vitamin D-associated genes affecting risk of early life wheeze

Thorax ◽

10.1136/thoraxjnl-2018-211962 ◽

2018 ◽

Vol 74 (2) ◽

pp. 200-202 ◽

Cited By ~ 3

Author(s):

Hooman Mirzakhani ◽

Amal A Al-Garawi ◽

Vincent J Carey ◽

Weiliang Qiu ◽

Augusto A Litonjua ◽

...

Keyword(s):

Vitamin D ◽

Cord Blood ◽

Transforming Growth Factor Beta ◽

Early Life ◽

Transforming Growth Factor ◽

First Year ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D ◽

Recurrent Wheeze ◽

First Year Of Life

Cord blood 25-hydroxyvitamin D (25OHD) has been reported in association with risk of early life recurrent wheeze. In a subset of infants who participated in the Vitamin D Antenatal Asthma Reduction Trial, we demonstrated that higher cord blood 25OHD at birth (>31 ng/mL) was associated with a reduced risk of recurrent wheeze in the first year of life. We then identified a module of co-expressed genes associated with cord blood 25OHD levels >31 ng/mL. Genes in this module are involved in biological and immune pathways related to development and progression of asthma pathogenesis including the Notch1 and transforming growth factor-beta signalling pathways.

Download Full-text

In Reply: The Causal Relationship of Total and Free 25-Hydroxyvitamin D and Vitamin D Binding Protein with Risk of Osteoporotic Fractures

Clinical Chemistry ◽

10.1093/clinchem/hvaa145 ◽

2020 ◽

Vol 66 (9) ◽

pp. 1242-1243

Author(s):

Yunus Çolak ◽

Shoaib Afzal ◽

Børge G Nordestgaard

Keyword(s):

Vitamin D ◽

Causal Relationship ◽

Binding Protein ◽

Osteoporotic Fractures ◽

Vitamin D Binding Protein ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D ◽

Relationship Of

Download Full-text

Correlation between Fecal Calprotectin Levels in Meconium and Vitamin D Levels in Cord Blood: Association with Intestinal Distress

Journal of Clinical Medicine ◽

10.3390/jcm9124089 ◽

2020 ◽

Vol 9 (12) ◽

pp. 4089

Author(s):

Jae Hoon Jung ◽

Sook Hyun Park

Keyword(s):

Vitamin D ◽

Cord Blood ◽

Fecal Calprotectin ◽

Vitamin D Status ◽

Hydroxyvitamin D ◽

Distress Symptoms ◽

Vitamin D Levels ◽

National University ◽

25 Hydroxyvitamin D ◽

Median Birth Weight

We aimed to investigate the correlation between vitamin D status in cord blood and fecal calprotectin concentrations in meconium, and also find their association with intestinal distress symptoms during the first two weeks of life. Two hundred and twenty-eight newborns were enrolled in the study who were delivered at Kyungpook National University Children’s Hospital between July 2016 and August 2017. The first passed meconium samples were collected for fecal calprotectin analysis. Intestinal distress involved infants with necrotizing enterocolitis (NEC) and other feeding interruption signs. The median gestational age of the population was 37.0 (34.3–38.4) weeks, and the median birth weight was 2635 (2100–3268) g. The median fecal calprotectin levels in meconium were 134.1 (55.6–403.2) μg/g (range: 11.5–2000 μg/g) and the median 25-hydroxyvitamin D (25-OHD) concentrations in cord blood were 21.0 (15.5–28.8) ng/mL. Sixty infants (26.3%) had intestinal distress, including four patients (1.8%) diagnosed as having NEC. Higher fecal calprotectin concentrations (398.2 (131.8–900.2) μg/g vs. 105.6 (39.4–248.5) μg/g, p < 0.001) and lower 25-OHD levels (17.9 (12.8–22.1) ng/mL vs. 23.2 (17.2–33.0) ng/mL, p < 0.001) were found in infants with intestinal distress compared to infants without intestinal distress. The cut-off value was set at 359.8 μg/g with a sensitivity of 0.53 and a specificity of 0.82 for the development of intestinal distress in the first two weeks of life. Serum 25-OHD levels in cord blood were inversely correlated with fecal calprotectin concentrations in meconium.

Download Full-text

Associations of Sun Exposure with 25-Hydroxyvitamin D and Parathyroid Hormone Levels in a Cohort of Hypertensive Patients: The Graz Endocrine Causes of Hypertension (GECOH) Study

International Journal of Endocrinology ◽

10.1155/2012/732636 ◽

2012 ◽

Vol 2012 ◽

pp. 1-8 ◽

Cited By ~ 2

Author(s):

Stefan Pilz ◽

Katharina Kienreich ◽

Daniel Stückler ◽

Andreas Meinitzer ◽

Andreas Tomaschitz

Keyword(s):

Vitamin D ◽

Parathyroid Hormone ◽

Scalp Hair ◽

Sun Exposure ◽

Hypertensive Patients ◽

Hydroxyvitamin D ◽

Outdoor Sports ◽

25 Hydroxyvitamin D ◽

Relationship Of ◽

The Relationship

Sunlight-induced vitamin D, synthesis in the skin is the major source of vitamin D, but data on the relationship of sun-related behaviour with vitamin D and parathyroid hormone (PTH) levels are relatively sparse. We evaluated whether habitual sun exposure is associated with 25-hydroxyvitamin D (25[OH]D) and PTH levels and whether there exist seasonal variations. We examined 111 hypertensive patients in Austria (latitude 47° N). Frequent sunbathing at home and outdoor sports were associated with higher 25(OH)D levels (P<0.05for both). Red or blond scalp hair as a child, memory of sunburns, preferring sunbathing, frequent stays on the beach or in open-air pools, and solarium use were associated with lower PTH levels (P<0.05for all). Multiple linear regression analyses including age, sex, and body mass index showed that sun exposure score was significantly associated with 25(OH)D (betacoefficient=0.27;P=0.004) and by trend with PTH (betacoefficient=−0.16;P=0.09). These associations were more prominent in summer in which 25(OH)D levels were significantly higher compared to winter. Translation of these findings into recommendations for the prevention and treatment of vitamin D deficiency remains a challenge for the future.

Download Full-text

Widespread 25-Hydroxyvitamin D Deficiency in Affluent and Nonaffluent Pregnant Indian Women

BioMed Research International ◽

10.1155/2014/892162 ◽

2014 ◽

Vol 2014 ◽

pp. 1-8 ◽

Cited By ~ 8

Author(s):

Rati Jani ◽

Suhaila Palekar ◽

Tanya Munipally ◽

Padmini Ghugre ◽

Shobha Udipi

Keyword(s):

Vitamin D ◽

Sun Exposure ◽

Cross Sectional Study ◽

Exposure Index ◽

Cross Sectional ◽

Indian Women ◽

Hydroxyvitamin D ◽

Dietary Phosphorus ◽

25 Hydroxyvitamin D ◽

Relationship Of

Objectives. This cross-sectional study primarily aimed to assess vitamin D adequacy in the third trimester of pregnancy using 25-hydroxyvitamin D (25(OH)D) and explore lifestyle characteristics (sun exposure index, diet, and economic indicators) associated with serum 25(OH)D. The secondary aim was to examine the relationship of serum 25(OH)D with birth weight and gestational age.Methods. Serum 25(OH)D was measured by chemiluminescent immunoassay in 150 pregnant women from Mumbai. Sun exposure index was computed. Dietary calcium, phytate : calcium ratio, and dietary phosphorus was calculated using the 24-hour diet recall method.Results. All women had 25(OH)D levels < 30.00 ng/ml. Multivariable linear regression showed that nonaffluent women had poorer 25(OH)D status than their affluent counterparts (β=-0.20;P=0.03). Higher sun exposure index was associated with higher 25(OH)D concentrations (β=0.31;P<0.001), which remained significant after controlling for covariates. At the bivariate level, mothers of infants weighing <2500 g had lower serum 25(OH)D concentrations compared to mothers whose infants weighed≥2500 g (P=0.02). This association became non-significant after controlling for covariates.Conclusions. Vitamin D deficiency was universally prevalent in the cohort studied. There is a need to develop culturally sensitive strategies for improving the 25(OH)D status.

Download Full-text

Prenatal Vitamin D Intake, Cord Blood 25-Hydroxyvitamin D, and Offspring Body Composition: The Healthy Start Study

Nutrients ◽

10.3390/nu9070790 ◽

2017 ◽

Vol 9 (7) ◽

pp. 790 ◽

Cited By ~ 7

Author(s):

Katherine Sauder ◽

Hallie Koeppen ◽

Allison Shapiro ◽

Kathryn Kalata ◽

Alexandra Stamatoiu ◽

...

Keyword(s):

Vitamin D ◽

Body Composition ◽

Cord Blood ◽

Healthy Start ◽

Hydroxyvitamin D ◽

Vitamin D Intake ◽

25 Hydroxyvitamin D

Download Full-text

Study on the Relationship of 25-hydroxyvitamin D and Intact Parathyroid Hormone in Chinese Adults

10.21203/rs.2.21603/v1 ◽

2020 ◽

Author(s):

Yichun Hu ◽

Siran Li ◽

Zhen Liu ◽

Lichen Yang ◽

Xiaoguang Yang

Keyword(s):

Vitamin D ◽

Parathyroid Hormone ◽

Intact Parathyroid Hormone ◽

Chinese Adults ◽

Serum Samples ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D ◽

Relationship Of ◽

The Relationship ◽

Ipth Concentration

Abstract Background:Vitamin D plays an important role in bone health and other diseases, however, there is no consensus over the optimal serum 25-hydroxyvitamin D (25(OH)D) concentration. Many studies consider that the 25(OH)D concerntration which maximally inhibit serum intact parathyroid hormone (iPTH) might be the optimal status for vitamin D sufficiency. This study was performed to study the relationship between 25(OH)D concentration and intact parathyroid hormone (iPTH) concentration in the Chinese non-clinical population aged 18-44y. Methods: The serum samples of adults aged 18-44 years old were selected from the established serum bank of Chinese Chronic Diseases and Nutrition Survey (CCDNS, 2015-2018). The serum 25(OH)D concentration was determined by high performance liquid chromatography tandem mass spectrometer, and the iPTH was determined by electronic chemiluminescence method. The relationship of 25(OH)D and iPTH were analyzed by correlation analysis, segmented linear regression and the confidence interval was determined by bootstrap method. Results: 623 serum samples (293 male, 330 female) of 25(OH)D concentration and iPTH concentration were analyzed. Significant higher 25(OH)D concentration was found in male than female. And the samples from the southern China had higher 25(OH)D concentration than those from the northern China. Samples from autumn had higher 25(OH)D concentration than those from spring and winter. The inversely relationship between 25(OH)D concentration and iPTH concentration was observed in both male and female. The concentration of 25(OH)D was 19.2 (10.1-27.2) ng/mL (P=0.02) when iPTH entered the plateau in women and no plateau for iPTH was found in men. Conclusions: The relationship between 25(OH)D and iPTH differs by sex among Chinese adults aged 18-44y. Further study is needed to evaluate the sex-specific ranges of optimal vitamin D. Trial registration: Not applicable. Keywords: 25-hydroxyvitamin D; parathyroid hormone; plateau; Chinese adults

Download Full-text

Maternal and cord blood vitamin D level and the infant gut microbiota in a birth cohort study

Maternal Health Neonatology and Perinatology ◽

10.1186/s40748-020-00119-x ◽

2020 ◽

Vol 6 (1) ◽

Author(s):

Zeinab Kassem ◽

Alexandra Sitarik ◽

Albert M. Levin ◽

Susan V. Lynch ◽

Suzanne Havstad ◽

...

Keyword(s):

Vitamin D ◽

Gut Microbiota ◽

Cord Blood ◽

Early Life ◽

Birth Cohort Study ◽

Childhood Health ◽

Future Studies ◽

Hydroxyvitamin D ◽

Operational Taxonomic Units ◽

25 Hydroxyvitamin D

Abstract Background Mounting evidence suggests both vitamin D and the early life gut microbiome influence childhood health outcomes. However, little is known about how these two important exposures are related. We aimed to examine associations between plasma 25-hydroxyvitamin D (25[OH]D) levels during pregnancy or at delivery (cord blood) and infant gut microbiota. Methods Maternal and cord blood 25[OH]D levels were assessed in a sample of pregnant women. Compositional analyses adjusted for race were run on the gut microbiota of their offspring at 1 and 6 months of age. Results Mean prenatal 25(OH)D level was 25.04 ± 11.62 ng/mL and mean cord blood 25(OH)D level was 10.88 ± 6.77 ng/mL. Increasing prenatal 25(OH)D level was significantly associated with decreased richness (p = 0.028) and diversity (p = 0.012) of the gut microbiota at 1 month of age. Both prenatal and cord 25(OH)D were significantly associated with 1 month microbiota composition. A total of 6 operational taxonomic units (OTUs) were significantly associated with prenatal 25(OH)D level (four positively and two negatively) while 11 OTUs were significantly associated with cord 25(OH)D (10 positively and one negatively). Of these, OTU 93 (Acinetobacter) and OTU 210 (Corynebacterium), were consistently positively associated with maternal and cord 25(OH)D; OTU 64 (Ruminococcus gnavus) was positively associated with prenatal 25(OH)D but negatively associated with cord 25(OH)D. Conclusions Prenatal maternal and cord blood 25(OH)D levels are associated with the early life gut microbiota. Future studies are needed to understand how vitamin D and the microbiome may interact to influence child health.

Download Full-text

Cross-sectional study of factors that influence the 25-hydroxyvitamin D status in pregnant women and in cord blood in Germany

British Journal Of Nutrition ◽

10.1017/s0007114513001438 ◽

2013 ◽

Vol 110 (10) ◽

pp. 1895-1902 ◽

Cited By ~ 27

Author(s):

Catrin Wuertz ◽

Peter Gilbert ◽

Wolfgang Baier ◽

Clemens Kunz

Keyword(s):

Vitamin D ◽

Cord Blood ◽

Pregnant Women ◽

Vitamin D Deficiency ◽

Maternal Blood ◽

Cross Sectional Study ◽

Cross Sectional ◽

Blood Samples ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D

There is increasing evidence of an association between a low maternal vitamin D status and a high risk of adverse pregnancy outcomes. In a cross-sectional study, we investigated the vitamin D status of pregnant women to determine potentially influencing factors. Between December 2010 and February 2012, 261 maternal blood samples and 328 cord blood samples were collected for the analysis of 25-hydroxyvitamin D (25(OH)D), intact parathyroid hormone, alkaline phosphatase and Ca concentrations. Demographical characteristics and clinical data were recorded by a questionnaire and from medical files. The overall median maternal and cord blood 25(OH)D levels were 25·0 (interquartile range 12·6–45·5) nmol/l and 34·1 (interquartile range 17·7–58·6) nmol/l, respectively. During the winter months, 98 % of the maternal blood samples and 94 % of the cord blood samples had 25(OH)D levels < 50 nmol/l. In the summer months, 49 % of the women and 35 % of the cord blood samples were vitamin D deficient. Using logistic regression models, significant risk factors for maternal vitamin D deficiency were found to be physical inactivity (adjusted OR (aOR) 2·67, 95 % CI 1·06, 6·69, P= 0·032) and a non-European country of origin (aOR 3·21, 95 % CI 1·0, 10·28, P= 0·047) after controlling for season and independent risk factors. These results are the first 25(OH)D data for pregnant women in Germany. They indicate the need for urgent implementation of strategies to prevent vitamin D deficiency by healthcare authorities that are in charge of preventing vitamin D deficiency, especially during these sensitive stages of life.

Download Full-text

Relationship of vitamin D, BMI and BMD in age and gender linked population

International Journal of Research in Orthopaedics ◽

10.18203/issn.2455-4510.intjresorthop20181439 ◽

2018 ◽

Vol 4 (3) ◽

pp. 406

Author(s):

Ritwik Ganguli ◽

Priyanka Pahari

Keyword(s):

Vitamin D ◽

Vitamin D Insufficiency ◽

Healthy Individuals ◽

Mineral Density ◽

Hydroxyvitamin D ◽

Vitamin D Levels ◽

25 Hydroxyvitamin D ◽

And Gender ◽

Relationship Of ◽

The Relationship

Background: Vitamin D insufficiency prevalence has been related to low bone mineral density (BMD). However, controversial results have been reported for the relationship between serum 25-hydroxyvitamin D [25(OH)D] levels and BMD. This study was done to investigate whether serum 25(OH)D levels were associated with BMD in different age group and sex link population.Methods: This study involved, aged 40-70 yr, who is consecutively selected from KPCMCH, BMD camp. BMD was measured at the lumbar spine and femoral neck. The correlation between serum 25(OH)D levels and BMD was investigated.Results: Vitamin D levels for healthy and patients individuals at hospital. The age of 40 healthy subjects ranged from 40 to 70 years with the average of 55.30±10.30 years and body mass index (BMI) ranged from 18 to 37 kg/m2, with the of average of 28.90±5.20 kg/m2. Comparison between healthy and patients based on BMI and vitamin D level for the overweight BMI healthy individuals was 29.78±9.40 ng/ml, and that of hyperlipidemic patients was 24.47±8.78 ng/ml.Conclusions: In this study, there is significant different between healthy and patients group in vitamin D3level.BMD significantly decreased in patients group more elderly.

Download Full-text