Role of Tubulointerstitial Lesions in Predicting Renal Outcome among Pediatric onset Lupus Nephritis – A Retrospective Cohort Study

Abstract Background Regarding the inconclusive results of previous investigations, this study aimed to determine the association between pathology, as a possible predictor, with remission outcomes, to know the role of pathology in the personalized decision making in acromegaly patients. Methods A retrospective cohort study was performed on the consecutive surgeries for growth hormone (GH) producing pituitary adenomas from February 2015 to January 2021. Seventy-one patients were assessed for granulation patterns and prolactin co-expression as dual staining adenomas. The role of pathology and some other predictors on surgical remission was evaluated using logistic regression models. Results Among 71 included patients, 34 (47.9%) patients had densely granulated (DG), 14 (19.7%) had sparsely granulated (SG), 23 (32.4%) had dual staining pituitary adenomas. The remission rate was about 62.5% in the patients with SG and DG adenomas named single staining and 52.2% in dual staining groups. Postoperative remission was 1.53-folds higher in the single staining adenomas than dual staining-one (non-significant). The remission rate was doubled in DG group compared to two other groups (non-significant). By adjusting different predictors, cavernous sinus invasion and one-day postoperative GH levels decreased remission rate by 91% (95% CI: 0.01–0.67; p = 0.015) and 64% (95% CI: 0.19–0.69; p < 0.001), respectively. Responses to the medications were not significantly different among three groups. Conclusion Various pathological subtypes of pituitary adenomas do not appear to have a predictive role in estimating remission outcomes. Cavernous sinus invasion followed by one-day postoperative GH is the strongest parameter to predict biochemical remission.

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Liver transplant for large hepatocellular carcinoma in Malatya: The role of gamma glutamyl transferase and alpha-fetoprotein, a retrospective cohort study

World Journal of Gastrointestinal Surgery ◽

10.4240/wjgs.v12.i12.520 ◽

2020 ◽

Vol 12 (12) ◽

pp. 520-533

Author(s):

Volkan Ince ◽

Brian I Carr ◽

Harika Gozukara Bag ◽

Veysel Ersan ◽

Sertac Usta ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Cohort Study ◽

Liver Transplant ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Alpha Fetoprotein ◽

Gamma Glutamyl Transferase ◽

Large Hepatocellular Carcinoma ◽

Glutamyl Transferase

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The role of red blood cell exchange for severe imported malaria in the artesunate era: a retrospective cohort study in a referral centre

Malaria Journal ◽

10.1186/s12936-016-1264-z ◽

2016 ◽

Vol 15 (1) ◽

Cited By ~ 13

Author(s):

Antonia Calvo-Cano ◽

Joan Gómez-Junyent ◽

Miguel Lozano ◽

Pedro Castro ◽

Joan Cid ◽

...

Keyword(s):

Cohort Study ◽

Blood Cell ◽

Red Blood Cell ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Imported Malaria ◽

Referral Centre

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Effects on renal outcome of concomitant acute pyelonephritis, acute kidney injury and obstruction duration in obstructive uropathy by urolithiasis: a retrospective cohort study

BMJ Open ◽

10.1136/bmjopen-2019-030438 ◽

2019 ◽

Vol 9 (11) ◽

pp. e030438

Author(s):

Eung Hyun Lee ◽

Su-Hyun Kim ◽

Jung-ho Shin ◽

Sung Bin Park ◽

Byung Hoon Chi ◽

...

Keyword(s):

Acute Kidney Injury ◽

Renal Function ◽

Cohort Study ◽

Retrospective Cohort Study ◽

Acute Pyelonephritis ◽

Retrospective Cohort ◽

Obstructive Uropathy ◽

Kidney Injury ◽

Renal Outcome ◽

Factors Affecting

ObjectiveObstruction release from urolithiasis can be delayed with a lack of suggested time for preventing the deterioration of renal function. The objective of this study was to investigate the effect of obstruction duration, concomitant acute kidney injury (AKI) or acute pyelonephritis (APN) during the obstruction on the prognosis of renal function.DesignRetrospective cohort study.Setting and participants1607 patients from a urolithiasis-related obstructive uropathy cohort, between January 2005 and December 2015.Outcome measuresEstimated glomerular filtration rate (eGFR) decrease ≥30% and/or end-stage renal disease (ESRD), and eGFR decrease ≥50% and/or ESRD, according to obstruction duration, AKI and APN accompanied by obstructive uropathy.ResultsWhen the prognosis was divided by obstruction duration quartile, the longer the obstruction duration the higher the probability of eGFR reduction >50% (p=0.02). In patients with concomitant APN or severe AKI during hospitalisation with obstructive uropathy, an eGFR decrease of >30% and >50% occurred more frequently, compared with others (p<0.001). When we adjusted for sex, age, hypertension, diabetes mellitus, APN, AKI grades and obstruction release >7 days for multivariate analysis, we found that concomitant APN (HR 3.495, 95% CI 1.942 to 6.289, p<0.001), concomitant AKI (HR 3.284, 95% CI 1.354 to 7.965, p=0.009 for AKI stage II; HR 6.425, 95% CI 2.599 to 15.881, p<0.001 for AKI stage III) and an obstruction duration >7 days (HR 1.854, 95% CI 1.095 to 3.140, p=0.001) were independently associated with an eGFR decrease >50%. Tree analysis also showed that AKI grade 3, APN and an obstruction duration >7 days were the most important factors affecting renal outcome.ConclusionsIn patients with urolithiasis-related obstructive uropathy, concomitant APN was strongly associated with deterioration of renal function after obstruction release. The elapsed time to release the obstruction also affected renal function.

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