scholarly journals Characterization of T cell, B cell and Natural Killer Cell Subsets in COVID-19 Patients

2021 ◽  
Vol 147 (2) ◽  
pp. AB79
Author(s):  
Alena Rynda ◽  
Andrei Hancharou ◽  
Natalia Antonevich ◽  
Oxana Timohina ◽  
Yana Minich ◽  
...  
2000 ◽  
Vol 79 (11) ◽  
pp. 635-639 ◽  
Author(s):  
K. Gloeckner-Hofmann ◽  
K. Ottesen ◽  
S. Schmidt ◽  
H. Nizze ◽  
A. C. Feller ◽  
...  

2014 ◽  
Author(s):  
Wan-Chung Hu

AbstractTfh initiates four eradicable immunities. Tfh includes FDC, LTi, IL21 CD4 T cell, and IgG/M B cell. Treg initiates four tolerable immunities. Treg includes DCreg, ILCreg, TGFβ CD4 T cell, and IgA B cell. TH1/TH1-like is immunity for intracellular bacteria/protozoa and type 4 delayed type hypersensitivity. TH1 includes M1 macrophage, mDC2, Tc1 CD8 T cell, IFNg CD4 T cell, ILC1, iNKT1, and IgG3 B cell. TH1-like includes M2 macrophage, ILC1, suppressive CD8 T cell, IFNg/TGFβ CD4 T cell, regulatory iNKT cells, and IgA1 B cell. TH2/TH9 is immunity for helminths and type1 IgE mediated hypersensitivity. TH2 includes iEOS eosinophil, Langerhans cell, basophil/MCt mast cell, IL-4 CD4 T cell, ILC2, iNKT2, and IgE/IgG4 B cell. TH9 includes rEOS eosinophil, basophils/mast cell MCct, IL-9 CD4 T cell, ILC2, regulatory iNKT cells, and IgA2 B cell. TH22/TH17 is immunity for extracellular bacteria/fungi and type 3 immune complex hypersensitivity. TH22 includes N1 neutrophils, mDC1, IL-22 CD4 T cell, ILC3(NCR+), iNKT17, and IgG2 B cell. TH17 includes N2 neutrophils, IL-17 CD4 T cell, regulatory iNKT cells, ILC3(NCR−), and IgA2 B cell. THαβ/TH3 is immunity for viruses and type 2 antibody dependent cytotoxic hypersensitivity. THαβ includes NK1 natural killer cell, pDC, Tc2 CD8 T cell, IL10 CD4 T cell, ILC10, iNKT10, and IgG1 B cell. TH3 includes NK2 natural killer cell, suppressive CD8 T cell, ILC10, IL-10/TGFβ CD4 T cell, regulatory iNKT cells, and IgA1 B cell.Summary sentenceThe summarized framework of host immunities to explain their relations to specific pathogens and hypersensitivities


Leukemia ◽  
2008 ◽  
Vol 22 (6) ◽  
pp. 1214-1225 ◽  
Author(s):  
M B Kamath ◽  
I B Houston ◽  
A J Janovski ◽  
X Zhu ◽  
S Gowrisankar ◽  
...  

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Shereen M. Reda ◽  
Heba S. Elabd ◽  
Rasha H. El-Owaidy ◽  
Ahmad M. Salah El Din ◽  
Mahmoud A. Hassan

2003 ◽  
Vol 77 (3) ◽  
pp. 286-294 ◽  
Author(s):  
Tatsuharu Ohno ◽  
Yasunori Ueda ◽  
Ken-ichi Nagai ◽  
Takayuki Takahashi ◽  
Yoshiteru Konaka ◽  
...  

Blood ◽  
2005 ◽  
Vol 105 (5) ◽  
pp. 1930-1936 ◽  
Author(s):  
Gina Balciunaite ◽  
Rhodri Ceredig ◽  
Antonius G. Rolink

Abstract The B-lymphocyte potential of progenitor thymocytes and whether the thymus is colonized by common lymphocyte progenitor cells have been subjects of considerable debate. Herein, we have used limiting dilution analysis to determine the lineage potential of phenotypically defined subpopulations of CD4–CD8– double-negative thymocytes. Culture systems used showed single-hit kinetics and had a high plating efficiency for B-, myeloid, and natural killer cell development. The T-cell potential of sorted cells was confirmed by transferring cells to fetal thymus organ cultures. Our results indicate that the earliest population of CD117+ double-negative cells, although containing potent T-cell developmental potential and significant myeloid and natural killer potential, does not have any residual B-cell potential. Gene transcription analysis also indicated that these double-negative cells contained abundant T and myeloid, but not B cell–specific transcripts. The implications of these results within the context of current models of thymocyte development are discussed.


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