Depression Scores and TNF-α in Participants of a Smoking Cessation Program

2021 ◽  
Vol 147 (2) ◽  
pp. AB82
Author(s):  
Kelsey Field ◽  
Cassandra Derella ◽  
Ryan Harris ◽  
Kathleen May ◽  
Martha Tingen
2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Cassandra C. Derella ◽  
Martha S. Tingen ◽  
Anson Blanks ◽  
Samantha J. Sojourner ◽  
Matthew A. Tucker ◽  
...  

AbstractSmoking increases systemic inflammation and circulating endothelin-1 (ET-1), both of which contribute to an elevated risk of cardiovascular disease (CVD). The present study sought to test the hypothesis that a 12-week smoking cessation intervention would contribute to a long-term reduction in circulating ET-1, tumor necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6). 30 individuals participated in a 12-week evidence-based smoking cessation program at Augusta University. Serum cotinine, plasma inflammatory cytokines, and plasma ET-1 were determined at baseline, immediately after the 12-week cessation program (end of treatment, EOT), and 12-months (12M) following the cessation program. Serum cotinine was significantly reduced (p < 0.001) at EOT and 12M following the smoking cessation program. Compared to BL (7.0 ± 1.6 pg/mL), TNF-α was significantly reduced at EOT (6.3 ± 1.5 pg/mL, p = 0.001) and 12M (5.2 ± 2.7 pg/mL, p < 0.001). ET-1 was significantly lower at EOT (1.9 ± 0.6 pg/mL, p = 0.013) and at 12M (2.0 ± 0.8 pg/mL, p = 0.091) following smoking cessation compared with BL (2.3 ± 0.6 pg/mL). BL concentrations of cotinine were significantly associated with basal ET-1 (r = 0.449, p = 0.013) and the change in cotinine at 12M following smoking cessation was significantly associated with the change in plasma ET-1 at 12M (r = 0.457, p = 0.011). Findings from the present pilot investigation demonstrate that a 12-week smoking cessation program reduces circulating concentrations of ET-1 and TNF-α for at least a year. The reduction in serum cotinine was associated with the decrease in circulating ET-1. The attenuation in ET-1 and inflammation may in part, contribute to the lower risk of CVD that is observed with smoking cessation.


Pflege ◽  
2003 ◽  
Vol 16 (5) ◽  
pp. 283-288 ◽  
Author(s):  
Jacqueline Voggensperger ◽  
Dunja Nicca ◽  
Battegay ◽  
Zellweger ◽  
Spirig

Das Zigarettenrauchen stellt für viele Menschen ein gesundheitliches Problem mit weitreichenden Folgen dar. Da das Rauchen für Patienten und Patientinnen der HIV-Sprechstunde am Universitätsspital Basel, Schweiz, ebenfalls ein großes Problem ist, konnte ein auf Evidenz basierendes Rauchstopp-Programm entwickelt werden. Dieses Programm stützt sich auf die zwei in der Literatur beschriebenen, erfolgreichen Interventionen; die Pharmakotherapie und die Beratung. Bei der Beratung steht der Dialog mit den Betroffenen und deren Empowerment im Zentrum. Das Rauchstopp-Programm beinhaltet eine Kurzintervention, eine allgemeine Raucherberatung und eine mehrteilige Einzelberatung. Da Raucherberatungen in der Schweiz bislang beinahe ausschließlich von Ärztinnen und Ärzten durchgeführt wurden und keine deutschsprachigen Publikationen von Pflegenden in diesem Gebiet existieren, beabsichtigt dieser Artikel, Pflegenden ein Konzept zur Raucherberatung anzubieten. Unsere ersten Praxiserfahrungen zeigen, dass insbesondere die Kombination bestehend aus pflegerischer und ärztlicher Langzeitbetreuung und Nikotinsubstitution eine wirksame interdisziplinäre Intervention darstellen könnte.


AIDS Care ◽  
2021 ◽  
pp. 1-9
Author(s):  
Stephanie A. Wiebe ◽  
Louise Balfour ◽  
William D. Cameron ◽  
Daniella Sandre ◽  
Crystal Holly ◽  
...  

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Mohammad Z. Darabseh ◽  
Thomas M. Maden-Wilkinson ◽  
George Welbourne ◽  
Rob C. I. Wüst ◽  
Nessar Ahmed ◽  
...  

AbstractCigarette smoking has a negative effect on respiratory and skeletal muscle function and is a risk factor for various chronic diseases. To assess the effects of 14 days of smoking cessation on respiratory and skeletal muscle function, markers of inflammation and oxidative stress in humans. Spirometry, skeletal muscle function, circulating carboxyhaemoglobin levels, advanced glycation end products (AGEs), markers of oxidative stress and serum cytokines were measured in 38 non-smokers, and in 48 cigarette smokers at baseline and after 14 days of smoking cessation. Peak expiratory flow (p = 0.004) and forced expiratory volume in 1 s/forced vital capacity (p = 0.037) were lower in smokers compared to non-smokers but did not change significantly after smoking cessation. Smoking cessation increased skeletal muscle fatigue resistance (p < 0.001). Haemoglobin content, haematocrit, carboxyhaemoglobin, total AGEs, malondialdehyde, TNF-α, IL-2, IL-4, IL-6 and IL-10 (p < 0.05) levels were higher, and total antioxidant status (TAS), IL-12p70 and eosinophil numbers were lower (p < 0.05) in smokers. IL-4, IL-6, IL-10 and IL-12p70 had returned towards levels seen in non-smokers after 14 days smoking cessation (p < 0.05), and IL-2 and TNF-α showed a similar pattern but had not yet fully returned to levels seen in non-smokers. Haemoglobin, haematocrit, eosinophil count, AGEs, MDA and TAS did not significantly change with smoking cessation. Two weeks of smoking cessation was accompanied with an improved muscle fatigue resistance and a reduction in low-grade systemic inflammation in smokers.


2013 ◽  
Vol 117 (3) ◽  
pp. 605-613 ◽  
Author(s):  
Susan M. Lee ◽  
Jennifer Landry ◽  
Philip M. Jones ◽  
Ozzie Buhrmann ◽  
Patricia Morley-Forster

2015 ◽  
Vol 146 ◽  
pp. e100 ◽  
Author(s):  
Patricia Simon ◽  
Christian Connell ◽  
Grace Kong ◽  
Meghan E. Morean ◽  
Dana A. Cavallo ◽  
...  

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