scholarly journals Mast cell chymase affects the functional properties of primary human airway fibroblasts: implications for asthma

Author(s):  
Xinran O. Zhao ◽  
Maria Lampinen ◽  
Ola Rollman ◽  
Christian P. Sommerhoff ◽  
Aida Paivandy ◽  
...  
2000 ◽  
Vol 41 (6) ◽  
pp. 975-984
Author(s):  
Miriam Lee ◽  
Patrizia Uboldi ◽  
Daniela Giudice ◽  
Alberico L. Catapano ◽  
Petri T. Kovanen

2006 ◽  
Vol 312 (8) ◽  
pp. 1289-1298 ◽  
Author(s):  
M LESKINEN ◽  
H HEIKKILA ◽  
M SPEER ◽  
J HAKALA ◽  
M LAINE ◽  
...  

Allergy ◽  
2018 ◽  
Author(s):  
Xiaoying Zhou ◽  
Tao Wei ◽  
Christopher W. Cox ◽  
Andrew F. Walls ◽  
Yuan Jiang ◽  
...  

2005 ◽  
Vol 145 (4) ◽  
pp. 424-431 ◽  
Author(s):  
Naotaka Shiota ◽  
Eiichi Kakizoe ◽  
Keiko Shimoura ◽  
Tetsuya Tanaka ◽  
Hideki Okunishi

1992 ◽  
Vol 99 (1) ◽  
pp. 133-140 ◽  
Author(s):  
R. De Forteza ◽  
K. Banovac ◽  
E. Koren

2002 ◽  
Vol 103 (s2002) ◽  
pp. 353S-356S ◽  
Author(s):  
Benjamin A. DE CAMPO ◽  
Roy G. GOLDIE ◽  
Arco Y. JENG ◽  
Peter J. HENRY

The present study examined the roles of endothelin-converting enzyme (ECE), neutral endopeptidase (NEP) and mast cell chymase as processors of the endothelin (ET) analogues ET-1(1–21), ET-1(1–31) and big ET-1 in the trachea of allergic mice. Male CBA/CaH mice were sensitized with ovalbumin (10µg) delivered intraperitoneal on days 1 and 14, and exposed to aerosolized ovalbumin on days 14, 25, 26 and 27 (OVA mice). Mice were killed and the trachea excised for histological analysis and contraction studies on day 28. Tracheae from OVA mice had 40% more mast cells than vehicle-sensitized mice (sham mice). Ovalbumin (10µg/ml) induced transient contractions (15±3% of the Cmax) in tracheae from OVA mice. The ECE inhibitor CGS35066 (10µM) inhibited contractions induced by big ET-1 (4.8-fold rightward shift of dose-response curve; P<0.05), but not those induced by either ET-1(1–21) or ET-1(1–31). The chymase inhibitors chymostatin (10µM) and Bowman-Birk inhibitor (10µM) had no effect on contractions induced by any of the ET analogues used. The NEP inhibitor CGS24592 (10µM) inhibited contractions induced by ET-1(1–31) (6.2-fold rightward shift; P<0.05) but not ET-1(1–21) or big ET-1. These data suggest that big ET-1 is processed predominantly by a CGS35066-sensitive ECE within allergic airways rather than by mast cell-derived proteases such as chymase. If endogenous ET-1(1–31) is formed within allergic airways, it is likely to undergo further conversion by NEP to more active products.


2003 ◽  
Vol 478 (2-3) ◽  
pp. 179-185 ◽  
Author(s):  
Yoshiaki Tomimori ◽  
Tsuyoshi Muto ◽  
Kayo Saito ◽  
Taisaku Tanaka ◽  
Hiroshi Maruoka ◽  
...  

1997 ◽  
Vol 344 (1) ◽  
pp. 133-138 ◽  
Author(s):  
Jeffrey H. Ware ◽  
X.Steven Wan ◽  
Harvey Rubin ◽  
Norman M. Schechter ◽  
Ann R. Kennedy

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