Overt speech critically changes lateralization index and did not allow determination of hemispheric dominance for language: an fMRI study

Background Pre-surgical mapping of language using functional MRI aimed principally to determine the dominant hemisphere. This mapping is currently performed using covert linguistic task in way to avoid motion artefacts potentially biasing the results. However, overt task is closer to natural speaking, allows a control on the performance of the task, and may be easier to perform for stressed patients and children. However, overt task, by activating phonological areas on both hemispheres and areas involved in pitch prosody control in the non-dominant hemisphere, is expected to modify the determination of the dominant hemisphere by the calculation of the lateralization index (LI). Objective Here, we analyzed the modifications in the LI and the interactions between cognitive networks during covert and overt speech task. Methods Thirty-three volunteers participated in this study, all but four were right-handed. They performed three functional sessions consisting of (1) covert and (2) overt generation of a short sentence semantically linked with an audibly presented word, from which we estimated the “Covert” and “Overt” contrasts, and a (3) resting-state session. The resting-state session was submitted to spatial independent component analysis to identify language network at rest (LANG), cingulo-opercular network (CO), and ventral attention network (VAN). The LI was calculated using the bootstrapping method. Results The LI of the LANG was the most left-lateralized (0.66 ± 0.38). The LI shifted from a moderate leftward lateralization for the Covert contrast (0.32 ± 0.38) to a right lateralization for the Overt contrast (− 0.13 ± 0.30). The LI significantly differed from each other. This rightward shift was due to the recruitment of right hemispheric temporal areas together with the nodes of the CO. Conclusion Analyzing the overt speech by fMRI allowed improvement in the physiological knowledge regarding the coordinated activity of the intrinsic connectivity networks. However, the rightward shift of the LI in this condition did not provide the basic information on the hemispheric language dominance. Overt linguistic task cannot be recommended for clinical purpose when determining hemispheric dominance for language.

Ohio primary results will help shape party agendas

Significance Both elections reflected deepening splits within the two parties. The Democratic primary pitched the party’s establishment against its progressive wing, while the Republican race was a test of the weight carried by former President Donald Trump’s endorsement. Ohio’s political environment also makes the two results significant. Impacts Failure to win Trump’s endorsement will not stop other Republicans from running on local issues in upcoming primaries. Ohio’s 18 votes in the Electoral College will make it an important battleground again in the 2024 presidential election. Despite the state’s rightward shift in 2016 and 2020, Democrats are likely to contest it fiercely in both 2022 and 2024.

SLL-PEEP Ventilation to Improve Exposure in Minimally Invasive Right Anterolateral Minithoracotomy Aortic Valve Replacement

Objective An accepted landmark to assess feasibility of surgical aortic valve replacement (SAVR) via right anterolateral minithoracotomy (RALT) is the aortic-midpoint to right-sternal-edge distance. We aimed to evaluate single left lung positive-end-expiratory-pressure (SLL-PEEP) ventilation inducing an intraoperative rightward shift of the ascending aorta to improve exposure. Methods Nineteen patients with aortic stenosis undergoing SAVR via RALT were prospectively analyzed. SLL-PEEP ventilation (20,395 cmH2O) via a double-lumen endotracheal tube was applied immediately before transthoracic aortic cross-clamping, thereby inducing rightward shift of the ascending aorta to enhance exposure. We analyzed preoperative computed tomography (CT) reconstructions and intraoperative video recordings. Primary endpoint was extent of rightward shift induced by SLL-PEEP ventilation; secondary endpoints were procedure times and safety events. Results Mean age was 61 ± 14.8 years and 6 of 19 (31.6%) were female. Mean EuroSCORE II was 0.81% ± 0.04%, STS-PROM was 1.13% ± 0.74%, and mean aortic rightward shift induced by SLL-PEEP ventilation was 10.32 ± 4.14 mm (4 to 17 mm; P = 0.003). Median shift in the group considered suitable for the RALT approach by preoperative CT-scan evaluation was 14.2 mm (IQR 11) and in the less suitable group 11.5 mm (IQR 5). Mean procedure time was 167 ± 28.9 min, CPB time was 105.7 ± 18.4 min, and cross-clamp time was 64.5 ± 13 min. Fifteen patients (79%) received SAVR via RALT with implantation of a bioprosthesis, whereas a rapid-deployment-prosthesis was used in 4 patients (21%). Ten of 19 (53%) patients who were classified as less suitable preoperatively received SAVR via RALT after SLL-PEEP ventilation. No strokes were observed. Conclusions The SLL-PEEP ventilation maneuver during SAVR via RALT significantly enhances aortic exposure. There were no safety events associated with this maneuver and we were able to demonstrate significant rightward aortic shift in every single patient.

No Evidence of Perceptual Pseudoneglect in Alexithymia

Neuroscience research links alexithymia, the difficulty in identifying and describing feelings and emotions, with left hemisphere dominance and/or right hemisphere deficit. To provide behavioral evidence for this neuroscientific hypothesis, we explored the relationship between alexithymia and performance in a line bisection task, a standard method for evaluating visuospatial processing in relation to right hemisphere functioning. We enrolled 222 healthy participants who completed a version of the 20-item Toronto Alexithymia Scale (TAS-20), which measures alexithymia, and were asked to mark (bisect) the center of a 10-cm horizontal segment. The results document a significant rightward shift in the center of the line in participants with borderline and manifest alexithymia compared with non-alexithymic individuals. The higher the TAS-20 score, the greater the rightward shift in the line bisection task. This finding supports the right hemisphere deficit hypothesis in alexithymia and suggests that visuospatial abnormalities may be an important component of this mental condition.

No Evidence of Perceptual Pseudoneglect in Alexithymia

The research in neuroscience links alexithymia, the difficulty of identifying and describing feelings and emotions, with a left hemisphere preference and/or a right hemisphere deficit. To provide a neuropsychological support to this finding, we explored the relationship between alexithymia and the performance in a line bisection task, a standard method to evaluate spatial attention in relation with the functioning of the right hemisphere. 222 healthy participants completed a version of the TAS-20 scale, which measures alexithymia, and were asked to mark (bisect) the center of a 10 cm horizontal segment. The results document a significant rightward shift of the line center in borderline and manifest alexithymic participants, as compared to non-alexithymic individuals. Moreover, the higher the TAS-20 score the greater the rightward shift in the line bisection task. This result supports the right-hemisphere deficit hypothesis in alexithymia and suggests that visuospatial abnormalities may be an inner component of their profile.

GANDHAKA RASAYANA PREPARATION AND ANALYSIS OF PHYSICOCHEMICAL PROPERTIES

The aims and objectives are to prepare Gandhaka Rasayana by the classical method mentioned in Ayurved Prakash and to evaluate parameters for process standardisation of Gandhaka Rasayana. Shuddha Gandhaka obtained by Shodhan procedure was powdered. In the preparation of Gandhaka Rasayana Bhavana Sanskar is the key element. Gandhaka Rasayana is prepared by 67 bhavanas made by nine different Bhavya dravya and their Upkalpana. The powder of Shuddha Gandhaka, Kwath, Swarasa and Phanta were prepared by the classical method. Physicochemical analysis was performed keeping in view of standardisation aspects of formulation. Final product standardisation is a part of thorough process standardisation. There is change in organoleptic properties in the process of Gandhaka Rasayana formulation. Ash value increased and % sulphur decreased as number of Bhavana increases. There was a rightward shift in pH in the formulation of Gandhaka Rasayana. Gandhaka Rasayana is the abundant source of Potassium. Gandhaka Rasayana is a nine step chain reaction resulting in the final product. Fingerprint of every step of Gandhaka Rasayana can be measured or quantified with the help of total Ash value, % Sulphur and Spectrophotometric analysis. Thus these parameters help us in the process Standardisation of Gandhaka Rasayana. Parameters for final product standardisations of Gandhaka Rasayana are pH value and evaluation of minerals from Flame photometry.

Sympathetic arterial baroreflex hysteresis in humans: different patterns during low- and high-pressure levels

The findings show that the arterial baroreflex processes diastolic pressure dependent on the direction of pressure change from the previous beat, yielding two distinct baroreflex response curves to falling and rising pressure. Overall, the falling pressure curve is rightward shifted and more sensitive. The rightward shift caused a hysteresis reversal at hypotensive pressures as the falling pressure saturation plateau of the sigmoid response curve occurred at higher pressures than the rising pressure curve.

Importing Political Polarization? The Electoral Consequences of Rising Trade Exposure

Has rising import competition contributed to the polarization of US politics? Analyzing multiple measures of political expression and results of congressional and presidential elections spanning the period 2000 through 2016, we find strong though not definitive evidence of an ideological realignment in trade-exposed local labor markets that commences prior to the divisive 2016 US presidential election. Exploiting the exogenous component of rising import competition by China, we find that trade exposed electoral districts simultaneously exhibit growing ideological polarization in some domains, meaning expanding support for both strong-left and strong-right views, and pure rightward shifts in others. Specifically, trade-impacted commuting zones or districts saw an increasing market share for the Fox News channel (a rightward shift), stronger ideological polarization in campaign contributions (a polarized shift), and a relative rise in the likelihood of electing a Republican to Congress (a rightward shift). Trade-exposed counties with an initial majority White population became more likely to elect a GOP conservative, while trade-exposed counties with an initial majority-minority population became more likely to elect a liberal Democrat, where in both sets of counties, these gains came at the expense of moderate Democrats (a polarized shift). In presidential elections, counties with greater trade exposure shifted toward the Republican candidate (a rightward shift). These results broadly support an emerging political economy literature that connects adverse economic shocks to sharp ideological realignments that cleave along racial and ethnic lines and induce discrete shifts in political preferences and economic policy. (JEL D72, F14, J15, L82, R23)