Immune-mediated acquired lecithin-cholesterol acyltransferase deficiency: A case report and literature review

2018 ◽  
Vol 12 (4) ◽  
pp. 888-897.e2 ◽  
Author(s):  
Ryoichi Ishibashi ◽  
Minoru Takemoto ◽  
Yuya Tsurutani ◽  
Masayuki Kuroda ◽  
Makoto Ogawa ◽  
...  
2021 ◽  
pp. 1-3
Author(s):  
Flor M Fernández-Gordón Sánchez ◽  
Flor M Fernández-Gordón Sánchez ◽  
Elena Gomez Dominguez ◽  
Cristina Garfia Castillo ◽  
Jorge Arroyo Andres ◽  
...  

Immunotherapy with checkpoint inhibitors is associated with termed inflammatory and immune-related side effects (irAE). Upper gastrointestinal symptoms are infrequent and appear mainly in patients on combination therapy with two checkpoint inhibitor drugs. We present the case of a patient with IIIB stage cutaneous melanoma treated with Nivolumab in monotherapy who developed an immune-mediated gastritis. Histopathologically, due to the paucity of published cases, no specific pattern of Nivolumab-immune-mediated gastritis has been described. We have reviewed the literature and compared the histopathology of the cases available in the literature.


2020 ◽  
pp. 1753495X2095057
Author(s):  
Raul Leal-Gonzalez ◽  
Álvaro Ramos-Reyes ◽  
Mariana Moncada-Madrazo ◽  
Irasema Apodaca-Ramos ◽  
Kimberly L Morales-Palomino ◽  
...  

Lecithin-cholesterol acyltransferase (LCAT) deficiency is a rare autosomal recessive condition affecting lipid metabolism with a prevalence of less than 1:1,000,000. Described here is the case of a 29-year-old pregnant woman with a diagnosis of LCAT deficiency (c.140G>A in exon 4), who had three episodes of hypertriglyceridemia-induced pancreatitis and nephrotic-range proteinuria throughout the pregnancy. Furthermore, fetal ultrasounds carried out during the second and third trimester revealed a steady reduction in fetal growth rate, and fetal growth restriction (FGR) was diagnosed. The woman underwent an elective caesarean section at 33 weeks of gestation and delivered a healthy neonate. This case report adds knowledge of the natural history of LCAT deficiency during pregnancy and will be useful in future patient management.


2015 ◽  
Vol 54 (13) ◽  
pp. 1647-1651 ◽  
Author(s):  
Gen Shihashi ◽  
Takuya Yagi ◽  
Shigeaki Suzuki ◽  
Morinobu Seki ◽  
Sumiko Kohashi ◽  
...  

2021 ◽  
Vol 2021 ◽  
pp. 1-3
Author(s):  
Hemnishil K. Marella ◽  
Jiten P. Kothadia ◽  
Nasir Saleem ◽  
Bilal Ali ◽  
Yousef Abdel-Aziz ◽  
...  

Acute herpes simplex esophagitis (HSE) is common in immunocompromised patients. Eosinophilic esophagitis (EoE) is characterized by immune-mediated eosinophil-predominant esophageal inflammation. We report a patient with human immunodeficiency virus infection who presented with dysphagia and odynophagia and was found to have HSE and EoE. The combination of these two relatively rare conditions suggests possible predisposition.


2014 ◽  
Vol 21 (2) ◽  
pp. 148-156 ◽  
Author(s):  
Nicholas P Forcello ◽  
Sapna Khubchandani ◽  
Shrina J Patel ◽  
Driola Brahaj

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